BAZ1B

Details:

UniProt Entry: Q9UIG0
Gene: BAZ1B
Class: RING
Family: RING10
Protein length: 1483
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 1f62, 5nnf

Protein Sequence ▾

>Q9UIG0
MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL
THKEAWEEEQ EVAELLKEEF PAWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC
DFEVGKEKML KVKIVKIHPL EKVDEEATEK KSDGACDSPS SDKENSSQIA QDHQKKETVV
KEDEGRRESI NDRARRSPRK LPTSLKKGER KWAPPKFLPH KYDVKLQNED KIISNVPADS
LIRTERPPNK EIVRYFIRHN ALRAGTGENA PWVVEDELVK KYSLPSKFSD FLLDPYKYMT
LNPSTKRKNT GSPDRKPSKK SKTDNSSLSS PLNPKLWCHV HLKKSLSGSP LKVKNSKNSK
SPEEHLEEMM KMMSPNKLHT NFHIPKKGPP AKKPGKHSDK PLKAKGRSKG ILNGQKSTGN
SKSPKKGLKT PKTKMKQMTL LDMAKGTQKM TRAPRNSGGT PRTSSKPHKH LPPAALHLIA
YYKENKDRED KRSALSCVIS KTARLLSSED RARLPEELRS LVQKRYELLE HKKRWASMSE
EQRKEYLKKK REELKKKLKE KAKERREKEM LERLEKQKRY EDQELTGKNL PAFRLVDTPE
GLPNTLFGDV AMVVEFLSCY SGLLLPDAQY PITAVSLMEA LSADKGGFLY LNRVLVILLQ
TLLQDEIAED YGELGMKLSE IPLTLHSVSE LVRLCLRRSD VQEESEGSDT DDNKDSAAFE
DNEVQDEFLE KLETSEFFEL TSEEKLQILT ALCHRILMTY SVQDHMETRQ QMSAELWKER
LAVLKEENDK KRAEKQKRKE MEAKNKENGK VENGLGKTDR KKEIVKFEPQ VDTEAEDMIS
AVKSRRLLAI QAKKEREIQE REMKVKLERQ AEEERIRKHK AAAEKAFQEG IAKAKLVMRR
TPIGTDRNHN RYWLFSDEVP GLFIEKGWVH DSIDYRFNHH CKDHTVSGDE DYCPRSKKAN
LGKNASMNTQ HGTATEVAVE TTTPKQGQNL WFLCDSQKEL DELLNCLHPQ GIRESQLKER
LEKRYQDIIH SIHLARKPNL GLKSCDGNQE LLNFLRSDLI EVATRLQKGG LGYVEETSEF
EARVISLEKL KDFGECVIAL QASVIKKFLQ GFMAPKQKRR KLQSEDSAKT EEVDEEKKMV
EEAKVASALE KWKTAIREAQ TFSRMHVLLG MLDACIKWDM SAENARCKVC RKKGEDDKLI
LCDECNKAFH LFCLRPALYE VPDGEWQCPA CQPATARRNS RGRNYTEESA SEDSEDDESD
EEEEEEEEEE EEEDYEVAGL RLRPRKTIRG KHSVIPPAAR SGRRPGKKPH STRRSQPKAP
PVDDAEVDEL VLQTKRSSRR QSLELQKCEE ILHKIVKYRF SWPFREPVTR DEAEDYYDVI
THPMDFQTVQ NKCSCGSYRS VQEFLTDMKQ VFTNAEVYNC RGSHVLSCMV KTEQCLVALL
HKHLPGHPYV RRKRKKFPDR LAEDEGDSEP EAVGQSRGRR QKK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
20	126	Domain	WSTF/Acf1/Cbp146	IPR013136	PS51136
22	119	Domain	WSTF/Acf1/Cbp146	IPR013136	PF10537
604	668	Domain	DDT domain	IPR018501	PS50827
604	668	Domain	DDT domain	IPR018501	SM00571
727	767	Domain	WHIM1 domain	IPR028942	PF15612
898	1024	Domain	WHIM2 domain	IPR028941	PF15613
1172	1236	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1184	1234	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
1185	1235	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1186	1232	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1186	1233	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
1187	1231	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
1187	1232	Domain	Zinc finger, RING-type	IPR001841	PS50089
1333	1448	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
1334	1444	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
1337	1445	Domain	Bromodomain	IPR001487	SM00297
1344	1440	Domain	Tyrosine-protein kinase BAZ1B, bromodomain	IPR037375	cd05505
1348	1429	Domain	Bromodomain	IPR001487	PF00439
1356	1426	Domain	Bromodomain	IPR001487	PS50014
1359	1372	Domain	Bromodomain	IPR001487	PR00503
1361	1418	Conserved_site	Bromodomain, conserved site	IPR018359	PS00633
1373	1389	Domain	Bromodomain	IPR001487	PR00503
1389	1407	Domain	Bromodomain	IPR001487	PR00503
1407	1426	Domain	Bromodomain	IPR001487	PR00503

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000107
GO:0006338	chromatin remodeling	Biological Process	IBA	GO_REF:0000033
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	NAS	PMID:10662543
GO:0006974	DNA damage response	Biological Process	IBA	GO_REF:0000033
GO:0043687	post-translational protein modification	Biological Process	IDA	PMID:19092802
GO:0045943	positive regulation of transcription by RNA polymerase I	Biological Process	NAS	PMID:23555303
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	NAS	PMID:26044184
GO:0045945	positive regulation of transcription by RNA polymerase III	Biological Process	IDA	PMID:16603771
GO:1905213	negative regulation of mitotic chromosome condensation	Biological Process	IDA	PMID:15543136
GO:0043596	nuclear replication fork	Cellular Component	IDA	PMID:15543136
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000117
GO:0000793	condensed chromosome	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	ISO	GO_REF:0000114
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005721	pericentric heterochromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005730	nucleolus	Cellular Component	NAS	PMID:23555303
GO:0090535	WICH complex	Cellular Component	IEA	GO_REF:0000002
GO:0110016	B-WICH complex	Cellular Component	IDA	PMID:16603771
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0004713	protein tyrosine kinase activity	Molecular Function	IEA	GO_REF:0000120
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:11980720
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016301	kinase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0035173	histone kinase activity	Molecular Function	IBA	GO_REF:0000033
GO:0042393	histone binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140801	histone H2AXY142 kinase activity	Molecular Function	IEA	GO_REF:0000002

Enzyme–Substrate Interactions ▾

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