MKRN1

Details:

UniProt Entry: Q9UHC7
Gene: MKRN1
Class: RING
Family: RING1
Protein length: 482
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9UHC7
MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT
CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT
ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE SRNSNFATVG AGSEDWVNAI EFVPGQPYCG
RTAPSCTEAP LQGSVTKEES EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG
LQVLHPMDAA QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG
ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE KEEKQKLILK
YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP QRQKVGTSSR YRAQRRNHFW
ELIEERENSN PFDNDEEEVV TFELGEMLLM LLAAGGDDEL TDSEDEWDLF HDELEDFYDL
DL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
55	82	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
55	81	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
57	80	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
59	453	Family	MKRN-like	IPR045072	PTHR11224
60	80	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
84	111	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
85	110	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
87	109	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
89	108	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
208	235	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
208	234	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
208	233	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
213	233	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
257	367	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
281	334	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
281	334	Domain	Zinc finger, RING-type	IPR001841	SM00184
281	335	Domain	Zinc finger, RING-type	IPR001841	PS50089
305	314	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
364	393	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
366	392	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
392	482	Domain	E3 ubiquitin-protein ligase makorin 1, C-terminal	IPR031644	PF15815

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8948757
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:19536131
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾


P46783	RS10	Yes	Yes	No	No	—	No	E3-specific
Q7Z7B0	FLIP1	Yes	Yes	No	No	—	No	E3-specific
O95259	KCNH1	Yes	No	No	No	—	No	E3-specific
P11940	PABP1	Yes	Yes	No	No	—	No	Cluster-specific
P54098	DPOG1	Yes	Yes	No	No	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P46783	RS10	Yes	Yes	No	No	—	No	E3-specific
Q7Z7B0	FLIP1	Yes	Yes	No	No	—	No	E3-specific
O95259	KCNH1	Yes	No	No	No	—	No	E3-specific
P11940	PABP1	Yes	Yes	No	No	—	No	Cluster-specific
P54098	DPOG1	Yes	Yes	No	No	—	No	E3-specific