KLHL3

Details:

UniProt Entry: Q9UH77
Gene: KLHL3
Class: Other E3 Components
Family: Adaptor
Protein length: 587
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UH77
MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE
IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV
QVLLPAASLL QLMDVRQNCC DFLQSQLHPT NCLGIRAFAD VHTCTDLLQQ ANAYAEQHFP
EVMLGEEFLS LSLDQVCSLI SSDKLTVSSE EKVFEAVISW INYEKETRLE HMAKLMEHVR
LPLLPRDYLV QTVEEEALIK NNNTCKDFLI EAMKYHLLPL DQRLLIKNPR TKPRTPVSLP
KVMIVVGGQA PKAIRSVECY DFEEDRWDQI AELPSRRCRA GVVFMAGHVY AVGGFNGSLR
VRTVDVYDGV KDQWTSIASM QERRSTLGAA VLNDLLYAVG GFDGSTGLAS VEAYSYKTNE
WFFVAPMNTR RSSVGVGVVE GKLYAVGGYD GASRQCLSTV EQYNPATNEW IYVADMSTRR
SGAGVGVLSG QLYATGGHDG PLVRKSVEVY DPGTNTWKQV ADMNMCRRNA GVCAVNGLLY
VVGGDDGSCN LASVEYYNPV TDKWTLLPTN MSTGRSYAGV AVIHKSL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	587	Family	BTB-kelch protein	IPR017096	PIRSF037037
18	148	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
29	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
40	146	Domain	BTB/POZ domain	IPR000210	PF00651
50	117	Domain	BTB/POZ domain	IPR000210	PS50097
50	147	Domain	BTB/POZ domain	IPR000210	SM00225
152	254	Domain	BTB/Kelch-associated	IPR011705	SM00875
152	254	Domain	BTB/Kelch-associated	IPR011705	PF07707
295	334	Repeat	Kelch repeat type 1	IPR006652	PF01344
297	587	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
301	582	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
302	347	Repeat	Kelch repeat type 1	IPR006652	SM00612
336	381	Repeat	Kelch repeat type 1	IPR006652	PF01344
348	394	Repeat	Kelch repeat type 1	IPR006652	SM00612
383	428	Repeat	Kelch repeat type 1	IPR006652	PF01344
395	441	Repeat	Kelch repeat type 1	IPR006652	SM00612
430	477	Repeat	Kelch repeat type 1	IPR006652	PF01344
442	490	Repeat	Kelch repeat type 1	IPR006652	SM00612
479	524	Repeat	Kelch repeat type 1	IPR006652	PF01344
491	537	Repeat	Kelch repeat type 1	IPR006652	SM00612
527	569	Repeat	Kelch repeat type 1	IPR006652	PF01344
538	585	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:23453970
GO:0070294	renal sodium ion absorption	Biological Process	ISS	PMID:14608358
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0016236	macroautophagy	Biological Process	TAS	PMID:26349538
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0050801	monoatomic ion homeostasis	Biological Process	IBA	GO_REF:0000033
GO:0055075	potassium ion homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0070293	renal absorption	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:23576762
GO:0072156	distal tubule morphogenesis	Biological Process	IMP	PMID:22406640
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0005198	structural molecule activity	Molecular Function	TAS	PMID:10843806
GO:0097602	cullin family protein binding	Molecular Function	IPI	PMID:14528312
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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