FXL17

Details:

UniProt Entry: Q9UF56
Gene: FBXL17
Class: Other E3 Components
Family: Receptor
Protein length: 701
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UF56
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS RDCFFRGPCM
LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL ARRYAALAAE DCAAAARRFL
LSSAAAAAAA AASASSPASC CKELGLAAAA AWEQQGRSLF LASLGPVRFL GPPAAVQLFR
GPTPSPAELP TPPEMVCKRK GAGVPACTPC KQPRCGGGGC GGGGGGGGGG GPAGGGASPP
RPPDAGCCQA PEQPPQPLCP PPSSPTSEGA PTEAGGDAVR AGGTAPLSAQ QQHECGDADC
RESPENPCDC HREPPPETPD INQLPPSILL KIFSNLSLDE RCLSASLVCK YWRDLCLDFQ
FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSMS DNGVCVLAFK CPGLLRYTAY
RCKQLSDTSI IAVASHCPLL QKVHVGNQDK LTDEGLKQLG SKCRELKDIH FGQCYKISDE
GMIVIAKGCL KLQRIYMQEN KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR
NLSSLDLRHI TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
SCKITDYALI AIGRYSMTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL MRCDKVNEVT
VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAS S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
313	378	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
318	365	Domain	F-box domain	IPR001810	PS50181
320	553	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
321	367	Domain	F-box domain	IPR001810	PF12937
324	365	Domain	F-box domain	IPR001810	SM00256
359	384	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
385	410	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
411	436	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
437	462	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
463	488	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
489	514	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
515	539	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
540	564	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
554	690	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
591	615	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
616	641	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
616	639	Repeat	Leucine-rich repeat	IPR001611	PF13516
642	667	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:27234298
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Biological Process	IDA	PMID:30190310
GO:0007399	nervous system development	Biological Process	ISS	GO_REF:0000024
GO:0008589	regulation of smoothened signaling pathway	Biological Process	IMP	PMID:27234298
GO:0014033	neural crest cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:24035498
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:30190310
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:24035498

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.