RNF14

Details:

UniProt Entry: Q9UBS8
Gene: RNF14
Class: RBR
Family: RBR
Protein length: 474
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9UBS8
MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS
VVLFAWMQFL KEETLAYLNI VSPFELKIGS QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE
EIVDERAVQD VESLSNLIQE ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH
VYCKACLKDY FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL
DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC KVTAEKLMDL
RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN SKSCPCCGTP IEKLDGCNKM
TCTGCMQYFC WICMGSLSRA NPYKHFNDPG SPCFNRLFYA VDVDDDIWED EVED

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	140	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
3	134	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
7	133	Domain	RWD domain	IPR006575	PF05773
11	137	Domain	RWD domain	IPR006575	PS50908
11	137	Domain	RWD domain	IPR006575	SM00591
66	441	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
213	300	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
216	457	Domain	TRIAD supradomain	IPR044066	PS51873
220	265	Domain	Zinc finger, RING-type	IPR001841	PS50089
238	247	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
289	350	Domain	IBR domain	IPR002867	SM00647
290	350	Domain	IBR domain	IPR002867	PF01485
386	453	Domain	IBR domain	IPR002867	SM00647
388	436	Domain	IBR domain	IPR002867	PF01485

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0060828	regulation of canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0006414	translational elongation	Biological Process	IDA	PMID:36638793
GO:0006415	translational termination	Biological Process	IDA	PMID:27863242
GO:0006355	regulation of DNA-templated transcription	Biological Process	IDA	PMID:19345326
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:10085091
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007165	signal transduction	Biological Process	TAS	PMID:10085091
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS	PMID:11322894
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IDA	PMID:19345326
GO:0060765	regulation of androgen receptor signaling pathway	Biological Process	IDA	PMID:19345326
GO:0072344	rescue of stalled ribosome	Biological Process	IDA	PMID:27863242
GO:0085020	protein K6-linked ubiquitination	Biological Process	IDA	PMID:27863242
GO:0160127	protein-RNA covalent cross-linking repair	Biological Process	IDA	PMID:37951215
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0022626	cytosolic ribosome	Cellular Component	IDA	PMID:27863242
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0003713	transcription coactivator activity	Molecular Function	TAS	PMID:10085091
GO:0005515	protein binding	Molecular Function	IPI	PMID:10085091
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IDA	PMID:11322894
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0050681	nuclear androgen receptor binding	Molecular Function	IPI	PMID:19345326

Enzyme–Substrate Interactions ▾


Q9UBS8	RNF14	Yes	Yes	No	No	—	No	E3-specific

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