HECW2

Details:

UniProt Entry: Q9P2P5
Gene: HECW2
Class: HECT
Family: HECT1
Protein length: 1572
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2lfe

Protein Sequence ▾

>Q9P2P5
MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ
IVWRIEPGPY FMEPEIKICF KYYHGISGAL RATTPCITVK NPAVMMGAEG MEGGASGNLH
SRKLVSFTLS DLRAVGLKKG MFFNPDPYLK MSIQPGKKSS FPTCAHHGQE RRSTIISNTT
NPIWHREKYS FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAIGDQMLS
YNLGRRLPAD HVSGYLQFKV EVTSSVHEDA SPEAVGTILG VNSVNGDLGS PSDDEDMPGS
HHDSQVCSNG PVSEDSAADG TPKHSFRTSS TLEIDTEELT STSSRTSPPR GRQDSLNDYL
DAIEHNGHSR PGTATCSERS MGASPKLRSS FPTDTRLNAM LHIDSDEEDH EFQQDLGYPS
SLEEEGGLIM FSRASRADDG SLTSQTKLED NPVENEEAST HEAASFEDKP ENLPELAESS
LPAGPAPEEG EGGPEPQPSA DQGSAELCGS QEVDQPTSGA DTGTSDASGG SRRAVSETES
LDQGSEPSQV SSETEPSDPA RTESVSEAST RPEGESDLEC ADSSCNESVT TQLSSVDTRC
SSLESARFPE TPAFSSQEEE DGACAAEPTS SGPAEGSQES VCTAGSLPVV QVPSGEDEGP
GAESATVPDQ EELGEVWQRR GSLEGAAAAA ESPPQEEGSA GEAQGTCEGA TAQEEGATGG
SQANGHQPLR SLPSVRQDVS RYQRVDEALP PNWEARIDSH GRIFYVDHVN RTTTWQRPTA
PPAPQVLQRS NSIQQMEQLN RRYQSIRRTM TNERPEENTN AIDGAGEEAD FHQASADFRR
ENILPHSTSR SRITLLLQSP PVKFLISPEF FTVLHSNPSA YRMFTNNTCL KHMITKVRRD
THHFERYQHN RDLVGFLNMF ANKQLELPRG WEMKHDHQGK AFFVDHNSRT TTFIDPRLPL
QSSRPTSALV HRQHLTRQRS HSAGEVGEDS RHAGPPVLPR PSSTFNTVSR PQYQDMVPVA
YNDKIVAFLR QPNIFEILQE RQPDLTRNHS LREKIQFIRT EGTPGLVRLS SDADLVMLLS
LFEEEIMSYV PPHALLHPSY CQSPRGSPVS SPQNSPGTQR ANARAPAPYK RDFEAKLRNF
YRKLETKGYG QGPGKLKLII RRDHLLEDAF NQIMGYSRKD LQRNKLYVTF VGEEGLDYSG
PSREFFFLVS RELFNPYYGL FEYSANDTYT VQISPMSAFV DNHHEWFRFS GRILGLALIH
QYLLDAFFTR PFYKALLRIL CDLSDLEYLD EEFHQSLQWM KDNDIHDILD LTFTVNEEVF
GQITERELKP GGANIPVTEK NKKEYIERMV KWRIERGVVQ QTESLVRGFY EVVDARLVSV
FDARELELVI AGTAEIDLSD WRNNTEYRGG YHDNHIVIRW FWAAVERFNN EQRLRLLQFV
TGTSSIPYEG FASLRGSNGP RRFCVEKWGK ITALPRAHTC FNRLDLPPYP SFSMLYEKLL
TAVEETSTFG LE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
45	164	Domain	E3 ubiquitin-protein ligase HECW1/2, N-terminal	IPR032348	PF16562
167	301	Domain	C2 domain	IPR000008	PS50004
185	321	Domain	E3 ubiquitin-protein ligase HECW, C2 domain	IPR037795	cd08691
186	297	Domain	C2 domain	IPR000008	SM00239
187	296	Domain	C2 domain	IPR000008	PF00168
188	336	Homologous_superfamily	C2 domain superfamily	IPR035892	G3DSA:2.60.40.150
190	292	Homologous_superfamily	C2 domain superfamily	IPR035892	SSF49562
806	841	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
807	840	Domain	WW domain	IPR001202	PS50020
808	840	Domain	WW domain	IPR001202	SM00456
809	838	Domain	WW domain	IPR001202	PF00397
810	839	Domain	WW domain	IPR001202	cd00201
813	838	Domain	WW domain	IPR001202	PS01159
916	981	Domain	E3 ubiquitin-protein ligase HECW1, helical box domain	IPR040524	PF18436
977	1019	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
985	1018	Domain	WW domain	IPR001202	PS50020
986	1018	Domain	WW domain	IPR001202	SM00456
988	1018	Domain	WW domain	IPR001202	cd00201
991	1016	Domain	WW domain	IPR001202	PS01159
1203	1566	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
1216	1570	Domain	HECT domain	IPR000569	cd00078
1235	1572	Domain	HECT domain	IPR000569	SM00119
1237	1572	Domain	HECT domain	IPR000569	PS50237
1268	1571	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0030071	regulation of mitotic metaphase/anaphase transition	Biological Process	IMP	PMID:24163370
GO:0048814	regulation of dendrite morphogenesis	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0072686	mitotic spindle	Cellular Component	IDA	PMID:24163370
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:24163370

Enzyme–Substrate Interactions ▾


P20700	LMNB1	Yes	No	No	No	—	No	E3-specific

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