KLH13

Details:

UniProt Entry: Q9P2N7
Gene: KLHL13
Class: Other E3 Components
Family: Adaptor
Protein length: 655
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9P2N7
MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGGS EMGLSSHLQS
SKAGPTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK
AMFTGGMKEQ DLMCIKLHGV SKVGLRKIID FIYTAKLSLN MDNLQDTLEA ASFLQILPVL
DFCKVFLISG VTLDNCVEVG RIANTYNLTE VDKYVNSFVL KNFPALLSTG EFLKLPFERL
AFVLSSNSLK HCTELELFKA TCRWLRLEEP RMDFAAKLMK NIRFPLMTPQ ELINYVQTVD
FMRTDNTCVN LLLEASNYQM MPYMQPVMQS DRTAIRSDTT HLVTLGGVLR QQLVVSKELR
MYDEKAHEWK SLAPMDAPRY QHGIAVIGNF LYVVGGQSNY DTKGKTAVDT VFRFDPRYNK
WMQVASLNEK RTFFHLSALK GYLYAVGGRN AAGELPTVEC YNPRTNEWTY VAKMSEPHYG
HAGTVYGGVM YISGGITHDT FQKELMCFDP DTDKWIQKAP MTTVRGLHCM CTVGERLYVI
GGNHFRGTSD YDDVLSCEYY SPILDQWTPI AAMLRGQSDV GVAVFENKIY VVGGYSWNNR
CMVEIVQKYD PDKDEWHKVF DLPESLGGIR ACTLTVFPPE ETTPSPSRES PLSAP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
49	642	Family	BTB-kelch protein	IPR017096	PIRSF037037
61	218	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
69	189	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
82	188	Domain	BTB/POZ domain	IPR000210	PF00651
92	161	Domain	BTB/POZ domain	IPR000210	PS50097
92	191	Domain	BTB/POZ domain	IPR000210	SM00225
196	297	Domain	BTB/Kelch-associated	IPR011705	PF07707
196	297	Domain	BTB/Kelch-associated	IPR011705	SM00875
326	639	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
341	633	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
341	389	Repeat	Kelch repeat type 1	IPR006652	SM00612
378	428	Repeat	Kelch repeat type 1	IPR006652	PF01344
390	441	Repeat	Kelch repeat type 1	IPR006652	SM00612
431	475	Repeat	Kelch repeat type 1	IPR006652	PF01344
442	488	Repeat	Kelch repeat type 1	IPR006652	SM00612
479	521	Repeat	Kelch repeat type 1	IPR006652	PF01344
489	535	Repeat	Kelch repeat type 1	IPR006652	SM00612
525	573	Repeat	Kelch repeat type 1	IPR006652	PF01344
536	587	Repeat	Kelch repeat type 1	IPR006652	SM00612
579	619	Repeat	Kelch repeat type 1	IPR006652	PF01344
588	636	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0032465	regulation of cytokinesis	Biological Process	IEA	GO_REF:0000117
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:14528312
GO:0097602	cullin family protein binding	Molecular Function	IBA	GO_REF:0000033

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.