KLH42

Details:

UniProt Entry: Q9P2K6
Gene: KLHL42
Class: Other E3 Components
Family: Adaptor
Protein length: 505
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9P2K6
MSAEEMVQIR LEDRCYPVSK RKLIEQSDYF RALYRSGMRE ALSQEAGGPE VQQLRGLSAP
GLRLVLDFIN AGGAREGWLL GPRGEKGGGV DEDEEMDEVS LLSELVEAAS FLQVTSLLQL
LLSQVRLNNC LEMYRLAQVY GLPDLQEACL RFMVVHFHEV LCKPQFHLLG SPPQAPGDVS
LKQRLREARM TGTPVLVALG DFLGGPLAPH PYQGEPPSML RYEEMTERWF PLANNLPPDL
VNVRGYGSAI LDNYLFIVGG YRITSQEISA AHSYNPSTNE WLQVASMNQK RSNFKLVAVN
SKLYAIGGQA VSNVECYNPE QDAWNFVAPL PNPLAEFSAC ECKGKIYVIG GYTTRDRNMN
ILQYCPSSDM WTLFETCDVH IRKQQMVSVE ETIYIVGGCL HELGPNRRSS QSEDMLTVQS
YNTVTRQWLY LKENTSKSGL NLTCALHNDG IYIMSRDVTL STSLEHRVFL KYNIFSDSWE
AFRRFPAFGH NLLVSSLYLP NKAET

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	72	Domain	BTB/POZ domain	IPR000210	PS50097
7	153	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
7	163	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
128	237	Domain	Kelch-like protein 42, BTB and C-terminal Kelch domain	IPR044727	cd18478
130	169	Domain	BTB/Kelch-associated	IPR011705	PF07707
196	486	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
213	495	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
245	288	Repeat	Kelch repeat type 1	IPR006652	PF01344
254	301	Repeat	Kelch repeat type 1	IPR006652	SM00612
291	331	Repeat	Kelch repeat type 1	IPR006652	PF01344
302	344	Repeat	Kelch repeat type 1	IPR006652	SM00612
345	391	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032886	regulation of microtubule-based process	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19261606
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514

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