KLHL8

Details:

UniProt Entry: Q9P2G9
Gene: KLHL8
Class: Other E3 Components
Family: Adaptor
Protein length: 620
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9P2G9
MASDSMSSKQ ARNHITKGKR QQQHQQIKNR SSISDGDGED SFIFEANEAW KDFHGSLLRF
YENGELCDVT LKVGSKLISC HKLVLACVIP YFRAMFLSEM AEAKQTLIEI RDFDGDAIED
LVKFVYSSRL TLTVDNVQPL LYAACILQVE LVARACCEYM KLHFHPSNCL AVRAFAESHN
RIDLMDMADQ YACDHFTEVV ECEDFVSVSP QHLHKLLSSS DLNIENEKQV YNAAIKWLLA
NPQHHSKWLD ETLAQVRLPL LPVDFLMGVV AKEQIVKQNL KCRDLLDEAR NYHLHLSSRA
VPDFEYSIRT TPRKHTAGVL FCVGGRGGSG DPFRSIECYS INKNSWFFGP EMNSRRRHVG
VISVEGKVYA VGGHDGNEHL GSMEMFDPLT NKWMMKASMN TKRRGIALAS LGGPIYAIGG
LDDNTCFNDV ERYDIESDQW STVAPMNTPR GGVGSVALVN HVYAVGGNDG MASLSSVERY
DPHLDKWIEV KEMGQRRAGN GVSKLHGCLY VVGGFDDNSP LSSVERYDPR SNKWDYVAAL
TTPRGGVGIA TVMGKIFAVG GHNGNAYLNT VEAFDPVLNR WELVGSVSHC RAGAGVAVCS
CLTSQIRDVG HGSNNVVDCM

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
21	317	Family	BTB-kelch protein	IPR017096	PIRSF037037
39	164	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
43	161	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
60	161	Domain	BTB/POZ domain	IPR000210	PF00651
67	164	Domain	BTB/POZ domain	IPR000210	SM00225
67	134	Domain	BTB/POZ domain	IPR000210	PS50097
169	270	Domain	BTB/Kelch-associated	IPR011705	PF07707
169	271	Domain	BTB/Kelch-associated	IPR011705	SM00875
309	425	Family	BTB-kelch protein	IPR017096	PIRSF037037
310	440	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
318	353	Repeat	Kelch repeat type 1	IPR006652	PF01344
319	366	Repeat	Kelch repeat type 1	IPR006652	SM00612
355	400	Repeat	Kelch repeat type 1	IPR006652	PF01344
362	599	Homologous_superfamily	Galactose oxidase/kelch, beta-propeller	IPR011043	SSF50965
367	413	Repeat	Kelch repeat type 1	IPR006652	SM00612
402	603	Family	BTB-kelch protein	IPR017096	PIRSF037037
403	447	Repeat	Kelch repeat type 1	IPR006652	PF01344
414	460	Repeat	Kelch repeat type 1	IPR006652	SM00612
441	606	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
449	493	Repeat	Kelch repeat type 1	IPR006652	PF01344
461	507	Repeat	Kelch repeat type 1	IPR006652	SM00612
496	538	Repeat	Kelch repeat type 1	IPR006652	PF01344
508	554	Repeat	Kelch repeat type 1	IPR006652	SM00612
543	586	Repeat	Kelch repeat type 1	IPR006652	PF01344
555	601	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:19158078
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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