MARH4

Details:

UniProt Entry: Q9P2E8
Gene: MARCHF4
Class: RING
Family: RING2
Protein length: 410
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9P2E8
MLMPLCGLLW WWWCCCSGWY CYGLCAPAPQ MLRHQGLLKC RCRMLFNDLK VFLLRRPPQA
PLPMHGDPQP PGLAANNTLP ALGAGGWAGW RGPREVVGRE PPPVPPPPPL PPSSVEDDWG
GPATEPPASL LSSASSDDFC KEKTEDRYSL GSSLDSGMRT PLCRICFQGP EQGELLSPCR
CDGSVKCTHQ PCLIKWISER GCWSCELCYY KYHVIAISTK NPLQWQAISL TVIEKVQVAA
AILGSLFLIA SISWLIWSTF SPSARWQRQD LLFQICYGMY GFMDVVCIGL IIHEGPSVYR
IFKRWQAVNQ QWKVLNYDKT KDLEDQKAGG RTNPRTSSST QANIPSSEEE TAGTPAPEQG
PAQAAGHPSG PLSHHHCAYT ILHILSHLRP HEQRSPPGSS RELVMRVTTV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
30	410	Family	E3 ubiquitin-protein ligase MARCHF4/9/11	IPR046356	PTHR46053
152	220	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
155	215	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
162	209	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
163	208	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0005795	Golgi stack	Cellular Component	IBA	GO_REF:0000033
GO:0005802	trans-Golgi network	Cellular Component	IBA	GO_REF:0000033
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P01911	DRB1	Yes	Yes	No	No	—	No	Cluster-specific
P01730	CD4	Yes	Yes	No	No	—	No	Cluster-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P01911	DRB1	Yes	Yes	No	No	—	No	Cluster-specific
P01730	CD4	Yes	Yes	No	No	—	No	Cluster-specific