IBTK

Details:

UniProt Entry: Q9P2D0
Gene: IBTK
Class: Other E3 Components
Family: Adaptor
Protein length: 1353
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9P2D0
MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS
SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL
SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK
QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH
TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT
REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD
IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW
RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN
LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA
VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS
EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY
QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML
QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF
PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN
VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG
LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL
KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTGL LKSGKTNSVE
SLPELLTSDS EGSYAGVGSP RDLQSPDFTT GFHSDKIEAK VKPYVNGTSP VYSREDLKPW
EKSPILKISA PQPIPSNRID TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK
SHLGKTVSHG VKLSQKQRKM IALTTKENNS GMNSMETVLF TPSKAPKPVN AWASSLHSVS
SKSFRDFLLE EKKSVTSHSS GDHVKKVSFK GIENSQAPKI VRCSTHGTPG PEGNHISDLP
LLDSPNPWLS SSVTAPSMVA PVTFASIVEE ELQQEAALIR SREKPLALIQ IEEHAIQDLL
VFYEAFGNPE EFVIVERTPQ GPLAVPMWNK HGC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	130	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
31	116	Repeat	Ankyrin repeat	IPR002110	PF12796
34	128	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	SSF48403
51	83	Repeat	Ankyrin repeat	IPR002110	PS50088
51	80	Repeat	Ankyrin repeat	IPR002110	SM00248
85	117	Repeat	Ankyrin repeat	IPR002110	PS50088
85	114	Repeat	Ankyrin repeat	IPR002110	SM00248
131	490	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
132	366	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
142	195	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
143	192	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
195	244	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
196	247	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
247	298	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
248	302	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
538	686	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
541	642	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
561	642	Domain	BTB/POZ domain	IPR000210	PF00651
564	644	Domain	BTB/POZ domain	IPR000210	PS50097
564	744	Domain	BTB/POZ domain	IPR000210	SM00225
740	900	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
761	870	Domain	BTB/POZ domain	IPR000210	PF00651
764	869	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
768	836	Domain	BTB/POZ domain	IPR000210	PS50097
768	871	Domain	BTB/POZ domain	IPR000210	SM00225

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001933	negative regulation of protein phosphorylation	Biological Process	IDA	PMID:11577348
GO:0051209	release of sequestered calcium ion into cytosol	Biological Process	IDA	PMID:11577348
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0030292	protein tyrosine kinase inhibitor activity	Molecular Function	IBA	GO_REF:0000033

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