VPS18

Details:

UniProt Entry: Q9P253
Gene: VPS18
Class: RING
Family: RING7
Protein length: 973
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9P253
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID FTPSERITSL
VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV HKMFLDHTGS HLLIALSSTE
VLYVNRNGQK VRPLARWKGQ LVESVGWNKA LGTESSTGPI LVGTAQGHIF EAELSASEGG
LFGPAPDLYF RPLYVLNEEG GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE
AQGFSGLFAA YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT GQVVLRDHFL
EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR TYLDMNRFDL AKEYCRERPD
CLDTVLAREA DFCFRQRRYL ESARCYALTQ SYFEEIALKF LEARQEEALA EFLQRKLASL
KPAERTQATL LTTWLTELYL SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR
ASIHELLASH GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME FCVNVLGETE
QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA LRLCAEHGHH RACVHVYKVL
ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE LRKKLWLKIA RHVVQEEEDV QTAMACLASC
PLLKIEDVLP FFPDFVTIDH FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL
RGRYGTVEPQ DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL MIRSIDRPFI
DPQRYEEEQL SWL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
291	434	Domain	Pep3/Vps18/deep orange	IPR007810	PF05131
618	772	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PS50236
639	768	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PF00637

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007032	endosome organization	Biological Process	IEA	GO_REF:0000107
GO:0046718	symbiont entry into host cell	Biological Process	IEA	GO_REF:0000107
GO:0006886	intracellular protein transport	Biological Process	IEA	GO_REF:0000002
GO:0006904	vesicle docking involved in exocytosis	Biological Process	IBA	GO_REF:0000033
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0007040	lysosome organization	Biological Process	IBA	GO_REF:0000033
GO:0008333	endosome to lysosome transport	Biological Process	IBA	GO_REF:0000033
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IMP	PMID:31015428
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Biological Process	IGI	PMID:31015428
GO:0034058	endosomal vesicle fusion	Biological Process	NAS	PMID:24554770
GO:0035542	regulation of SNARE complex assembly	Biological Process	NAS	PMID:24554770
GO:0048284	organelle fusion	Biological Process	IBA	GO_REF:0000033
GO:2000300	regulation of synaptic vesicle exocytosis	Biological Process	EXP	PMID:17027648
GO:0030123	AP-3 adaptor complex	Cellular Component	IEA	GO_REF:0000107
GO:0005768	endosome	Cellular Component	IBA	GO_REF:0000033
GO:0098793	presynapse	Cellular Component	IEA	GO_REF:0000120
GO:0098978	glutamatergic synapse	Cellular Component	EXP	PMID:17027648
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000120
GO:0005770	late endosome	Cellular Component	IDA	PMID:11382755
GO:0005776	autophagosome	Cellular Component	IEA	GO_REF:0000044
GO:0005884	actin filament	Cellular Component	IEA	GO_REF:0000107
GO:0010008	endosome membrane	Cellular Component	TAS	Reactome:R-HSA-9754537
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030136	clathrin-coated vesicle	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0031902	late endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0030897	HOPS complex	Cellular Component	IBA	GO_REF:0000033
GO:0033263	CORVET complex	Cellular Component	IEA	GO_REF:0000107
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:11382755
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0019905	syntaxin binding	Molecular Function	IDA	PMID:11382755
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IMP	PMID:31015428

Enzyme–Substrate Interactions ▾

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