ZBTB4

Details:

UniProt Entry: Q9P1Z0
Gene: ZBTB4
Class: RING
Family: RING6
Protein length: 1013
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q9P1Z0
MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL
TSAPLPLPPA TGGAAPNPAT TTAASSSSSS SSSSSSSSSS ASSSSSSSSS SPPPASPPAS
SPPRVLELPG VPAAAFSDVL NFIYSARLAL PGGGGDGAAV AEIGALGRRL GISRLQGLGE
GGDAWVPPTP APMATSQPEE DSFGPGPRPA GEWEGDRAEA QAPDLQCSLP RRPLPCPQCG
KSFIHPKRLQ THEAQCRRGA STRGSTGLGA GGAGPGGPAG VDASALPPPV GFRGGPEHVV
KVVGGHVLYV CAACERSYVT LSSLKRHSNV HSWRRKYPCR YCEKVFALAE YRTKHEVWHT
GERRYQCIFC WETFVTYYNL KTHQRAFHGI SPGLLASEKT PNGGYKPKLN TLKLYRLLPM
RAAKRPYKTY SQGAPEAPLS PTLNTPAPVA MPASPPPGPP PAPEPGPPPS VITFAHPAPS
VIVHGGSSSG GGGSGTASTG GSQAASVITY TAPPRPPKKR EYPPPPPEPA ATPTSPATAV
SPATAAGPAM ATTTEEAKGR NPRAGRTLTY TAKPVGGIGG GGGPPTGAGR GPSQLQAPPP
LCQITVRIGE EAIVKRRISE TDLRPGELSG EEMEESEEDE EEEDEEEEEE DEEESKAGGE
DQLWRPYYSY KPKRKAGAAG GASVGGSGLP RGRRPPRWRQ KLERRSWEET PAAESPAGRA
RTERRHRCGD CAQTFTTLRK LRKHQEAHGG GSHSSRAGRR PSTRFTCPHC AKVCKTAAAL
SRHGQRHAAE RPGGTPTPVI AYSKGSAGTR PGDVKEEAPQ EMQVSSSSGE AGGGSTAAEE
ASETASLQDP IISGGEEPPV VASGGSYVYP PVQEFPLALI GGGREPGGGR GKSGSEGPVG
AGEGDRMEGI GAAKVTFYPE PYPLVYGPQL LAAYPYNFSN LAALPVALNM VLPDEKGAGA
LPFLPGVFGY AVNPQAAPPA PPTPPPPTLP PPIPPKGEGE RAGVERTQKG DVG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	181	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
8	175	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
20	60	Domain	BTB/POZ domain	IPR000210	PF00651
30	187	Domain	BTB/POZ domain	IPR000210	SM00225
30	152	Domain	BTB/POZ domain	IPR000210	PS50097
232	331	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
234	254	Domain	Zinc finger C2H2-type	IPR013087	SM00355
234	262	Domain	Zinc finger C2H2-type	IPR013087	PS50157
309	331	Domain	Zinc finger C2H2-type	IPR013087	SM00355
309	336	Domain	Zinc finger C2H2-type	IPR013087	PS50157
311	331	Domain	Zinc finger C2H2-type	IPR013087	PS00028
331	383	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
337	359	Domain	Zinc finger C2H2-type	IPR013087	SM00355
337	364	Domain	Zinc finger C2H2-type	IPR013087	PS50157
339	359	Domain	Zinc finger C2H2-type	IPR013087	PS00028
365	388	Domain	Zinc finger C2H2-type	IPR013087	PS50157
365	388	Domain	Zinc finger C2H2-type	IPR013087	SM00355
367	388	Domain	Zinc finger C2H2-type	IPR013087	PS00028
726	748	Domain	Zinc finger C2H2-type	IPR013087	SM00355
726	753	Domain	Zinc finger C2H2-type	IPR013087	PS50157
728	748	Domain	Zinc finger C2H2-type	IPR013087	PS00028
765	792	Domain	Zinc finger C2H2-type	IPR013087	PS50157
765	787	Domain	Zinc finger C2H2-type	IPR013087	SM00355
767	787	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:16354688
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0006974	DNA damage response	Biological Process	IDA	PMID:19448668
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:16354688
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IDA	PMID:16354688
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:16354688
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16354688
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0008327	methyl-CpG binding	Molecular Function	IEA	GO_REF:0000117
GO:0010428	methyl-CpNpG binding	Molecular Function	IDA	PMID:20403812
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:19448668
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:16354688
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:20403812
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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