PHRF1

Details:

UniProt Entry: Q9P1Y6
Gene: PHRF1
Class: RING
Family: RING10
Protein length: 1649
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9P1Y6
MDDDSLDELV ARSPGPDGHP QVGPADPAGD FEESSVGSSG DSGDDSDSEH GDGTDGEDEG
ASEEEDLEDR SGSEDSEDDG ETLLEVAGTQ GKLEAAGSFN SDDDAESCPI CLNAFRDQAV
GTPENCAHYF CLDCIVEWSK NANSCPVDRT LFKCICIRAQ FGGKILRKIP VENTKASEEE
EDPTFCEVCG RSDREDRLLL CDGCDAGYHM ECLDPPLQEV PVDEWFCPEC AAPGVVLAAD
AGPVSEEEVS LLLADVVPTT SRLRPRAGRT RAIARTRQSE RVRATVNRNR ISTARRVQHT
PGRLGSSLLD EAIEAVATGL STAVYQRPLT PRTPARRKRK TRRRKKVPGR KKTPSGPSAK
SKSSATRSKK RQHRVKKRRG KKVKSEATTR SRIARTLGLR RPVHSSCIPS VLKPVEPSLG
LLRADIGAAS LSLFGDPYEL DPFDSSEELS ANPLSPLSAK RRALSRSALQ SHQPVARPVS
VGLSRRRLPA AVPEPDLEEE PVPDLLGSIL SGQSLLMLGS SDVIIHRDGS LSAKRAAPVS
FQRNSGSLSR GEEGFKGCLQ PRALPSGSPA QGPSGNRPQS TGLSCQGRSR TPARTAGAPV
RLDLPAAPGA VQARNLSNGS VPGFRQSHSP WFNGTNKHTL PLASAASKIS SRDSKPPCRS
VVPGPPLKPA PRRTDISELP RIPKIRRDDG GGRRDAAPAH GQSIEIPSAC ISRLTGREGT
GQPGRGTRAE SEASSRVPRE PGVHTGSSRP PAPSSHGSLA PLGPSRGKGV GSTFESFRIN
IPGNMAHSSQ LSSPGFCNTF RPVDDKEQRK ENPSPLFSIK KTKQLRSEVY DPSDPTGSDS
SAPGSSPERS GPGLLPSEIT RTISINSPKA QTVQAVRCVT SYTVESIFGT EPEPPLGPSS
AMSKLRGAVA AEGASDTERE EPTESQGLAA RLRRPSPPEP WDEEDGASCS TFFGSEERTV
TCVTVVEPEA PPSPDVLQAA THRVVELRPP SRSRSTSSSR SRKKAKRKRV SREHGRTRSG
TRSESRDRSS RSASPSVGEE RPRRQRSKAK SRRSSSDRSS SRERAKRKKA KDKSREHRRG
PWGHSRRTSR SRSGSPGSSS YEHYESRKKK KRRSASRPRG RECSPTSSLE RLCRHKHQRE
RSHERPDRKE SVAWPRDRRK RRSRSPSSEH RAREHRRPRS REKWPQTRSH SPERKGAVRE
ASPAPLAQGE PGREDLPTRL PALGEAHVSP EVATADKAPL QAPPVLEVAA ECEPDDLDLD
YGDSVEAGHV FDDFSSDAVF IQLDDMSSPP SPESTDSSPE RDFPLKPALP PASLAVAAIQ
REVSLMHDED PSQPPPLPEG TQEPHLLRPD AAEKAEAPSS PDVAPAGKED SPSASGRVQE
AARPEEVVSQ TPLLRSRALV KRVTWNLQES ESSAPAEDRA PRAPLHRPQK PREGAWDMED
VAPTGVRQVF SELPFPSHVL PEPGFPDTDP SQVYSPGLPP APAQPSSIPP CALVSQPTVQ
FILQGSLPLV GCGAAQTLAP VPAALTPASE PASQATAASN SEEKTPAPRL AAEKTKKEEY
MKKLHMQERA VEEVKLAIKP FYQKREVTKE EYKDILRKAV QKICHSKSGE INPVKVANLV
KAYVDKYRHM RRHKKPEAGE EPPTQGAEG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
72	154	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
107	148	Domain	Zinc finger, RING-type	IPR001841	PF13639
108	149	Domain	Zinc finger, RING-type	IPR001841	PS50089
108	148	Domain	Zinc finger, RING-type	IPR001841	SM00184
126	135	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
170	241	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
171	231	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
183	233	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
185	231	Domain	Zinc finger, PHD-type	IPR001965	SM00249
185	231	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
186	230	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21988832
GO:0070063	RNA polymerase binding	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.