RN181

Details:

UniProt Entry: Q9P0P0
Gene: RNF181
Class: RING
Family: RING4
Protein length: 153
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9P0P0
MASYFDEHDC EPSDPEQETR TNMLLELARS LFNRMDFEDL GLVVDWDHHL PPPAAKTVVE
NLPRTVIRGS QAELKCPVCL LEFEEEETAI EMPCHHLFHS SCILPWLSKT NSCPLCRYEL
PTDDDTYEEH RRDKARKQQQ QHRLENLHGA MYT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
45	124	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
75	117	Domain	Zinc finger, RING-type	IPR001841	PF13639
76	116	Domain	Zinc finger, RING-type	IPR001841	SM00184
76	117	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24105792
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:19690564
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9P0P0	RN181	Yes	No	No	No	—	No	E3-specific
P08514	ITA2B	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9P0P0	RN181	Yes	No	No	No	—	No	E3-specific
P08514	ITA2B	Yes	Yes	No	No	—	No	E3-specific