MARH2

Details:

UniProt Entry: Q9P0N8
Gene: MARCHF2
Class: RING
Family: RING2
Protein length: 246
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9P0N8
MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD
GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR
PLTEWLKDPG PRTEKRTLCC DMVCFLFITP LAAISGWLCL RGAQDHLRLH SQLEAVGLIA
LTIALFTIYV LWTLVSFRYH CQLYSEWRKT NQKVRLKIRE ADSPEGPQHS PLAAGLLKKV
AEETPV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
51	124	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
56	116	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
63	110	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
64	109	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906
64	110	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006897	endocytosis	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0044790	suppression of viral release by host	Biological Process	IMP	PMID:29573664
GO:0140367	antibacterial innate immune response	Biological Process	ISS	GO_REF:0000024
GO:0140374	antiviral innate immune response	Biological Process	ISS	GO_REF:0000024
GO:1905167	positive regulation of lysosomal protein catabolic process	Biological Process	IMP	PMID:29573664
GO:0010008	endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA	PMID:14722266
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:17980554
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P02786	TFR1	Yes	Yes	No	No	—	No	Cluster-specific
P42081	CD86	Yes	Yes	No	No	—	No	Cluster-specific
Q9Y282	ERGI3	Yes	No	Yes	No	31142615, 32296183	EBI-23781388	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P02786	TFR1	Yes	Yes	No	No	—	No	Cluster-specific
P42081	CD86	Yes	Yes	No	No	—	No	Cluster-specific
Q9Y282	ERGI3	Yes	No	Yes	No	31142615, 32296183	EBI-23781388	E3-specific