KCMF1

Details:

UniProt Entry: Q9P0J7
Gene: KCMF1
Class: RING
Family: RING1
Protein length: 381
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9P0J7
MSRHEGVSCD ACLKGNFRGR RYKCLICYDY DLCASCYESG ATTTRHTTDH PMQCILTRVD
FDLYYGGEAF SVEQPQSFTC PYCGKMGYTE TSLQEHVTSE HAETSTEVIC PICAALPGGD
PNHVTDDFAA HLTLEHRAPR DLDESSGVRH VRRMFHPGRG LGGPRARRSN MHFTSSSTGG
LSSSQSSYSP SNREAMDPIA ELLSQLSGVR RSAGGQLNSS GPSASQLQQL QMQLQLERQH
AQAARQQLET ARNATRRTNT SSVTTTITQS TATTNIANTE SSQQTLQNSQ FLLTRLNDPK
MSETERQSME SERADRSLFV QELLLSTLVR EESSSSDEDD RGEMADFGAM GCVDIMPLDV
ALENLNLKES NKGNEPPPPP L

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	56	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
3	48	Domain	Zinc finger, ZZ-type	IPR000433	SM00291
4	47	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
4	60	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
9	36	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
76	137	Domain	Drought induced 19 protein type, zinc-binding domain	IPR008598	PF05605
78	101	Domain	Zinc finger C2H2-type	IPR013087	SM00355
78	106	Domain	Zinc finger C2H2-type	IPR013087	PS50157

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002181	cytoplasmic translation	Biological Process	IC	PMID:23636399
GO:0006413	translational initiation	Biological Process	IDA	PMID:16289705
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34893540
GO:0006979	response to oxidative stress	Biological Process	IDA	PMID:34893540
GO:0033554	cellular response to stress	Biological Process	IDA	PMID:32132706
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:34893540
GO:0071211	protein targeting to vacuole involved in autophagy	Biological Process	IDA	PMID:34893540
GO:0140468	HRI-mediated signaling	Biological Process	IDA	PMID:32132706
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:37891180
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:34893540
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:38297121
GO:0099536	synaptic signaling	Biological Process	IBA	GO_REF:0000033
GO:0141191	negative regulation of HRI-mediated signaling	Biological Process	IDA	PMID:38297121
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:38297121
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005576	extracellular region	Cellular Component	TAS	Reactome:R-HSA-6800434
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005770	late endosome	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000108
GO:1904813	ficolin-1-rich granule lumen	Cellular Component	TAS	Reactome:R-HSA-6800434
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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