KCND2

Details:

UniProt Entry: Q9NZV8
Gene: KCND2
Class: Other E3 Components
Family: Adaptor
Protein length: 630
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NZV8
MAAGVAAWLP FARAAAIGWM PVASGPMPAP PRQERKRTQD ALIVLNVSGT RFQTWQDTLE
RYPDTLLGSS ERDFFYHPET QQYFFDRDPD IFRHILNFYR TGKLHYPRHE CISAYDEELA
FFGLIPEIIG DCCYEEYKDR RRENAERLQD DADTDTAGES ALPTMTARQR VWRAFENPHT
STMALVFYYV TGFFIAVSVI ANVVETVPCG SSPGHIKELP CGERYAVAFF CLDTACVMIF
TVEYLLRLAA APSRYRFVRS VMSIIDVVAI LPYYIGLVMT DNEDVSGAFV TLRVFRVFRI
FKFSRHSQGL RILGYTLKSC ASELGFLLFS LTMAIIIFAT VMFYAEKGSS ASKFTSIPAA
FWYTIVTMTT LGYGDMVPKT IAGKIFGSIC SLSGVLVIAL PVPVIVSNFS RIYHQNQRAD
KRRAQKKARL ARIRAAKSGS ANAYMQSKRN GLLSNQLQSS EDEQAFVSKS GSSFETQHHH
LLHCLEKTTN HEFVDEQVFE ESCMEVATVN RPSSHSPSLS SQQGVTSTCC SRRHKKTFRI
PNANVSGSHQ GSIQELSTIQ IRCVERTPLS NSRSSLNAKM EECVKLNCEQ PYVTTAIISI
PTPPVTTPEG DDRPESPEYS GGNIVRVSAL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	144	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	30	Domain	Shal-type voltage-gated potassium channels, N-terminal	IPR021645	PF11601
30	42	Family	Potassium channel, voltage dependent, Kv4.2	IPR004055	PR01517
41	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
41	140	Domain	BTB/POZ domain	IPR000210	SM00225
43	132	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
68	81	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
82	92	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
143	159	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
148	164	Family	Potassium channel, voltage dependent, Kv4.2	IPR004055	PR01517
157	306	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
161	175	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
180	194	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
186	416	Domain	Ion transport domain	IPR005821	PF00520
220	236	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
299	307	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
318	337	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
323	337	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
394	405	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
415	426	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
429	445	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
461	473	Family	Potassium channel, voltage dependent, Kv4.2	IPR004055	PR01517
472	545	Domain	Potassium channel, voltage dependent, Kv4, C-terminal	IPR024587	PF11879
475	489	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
560	573	Family	Potassium channel, voltage dependent, Kv4.2	IPR004055	PR01517
580	592	Family	Potassium channel, voltage dependent, Kv4.2	IPR004055	PR01517

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0019228	neuronal action potential	Biological Process	IEA	GO_REF:0000107
GO:0019233	sensory perception of pain	Biological Process	IEA	GO_REF:0000107
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0045475	locomotor rhythm	Biological Process	IEA	GO_REF:0000107
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0060078	regulation of postsynaptic membrane potential	Biological Process	IEA	GO_REF:0000108
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000120
GO:0086009	membrane repolarization	Biological Process	IEA	GO_REF:0000117
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006936	muscle contraction	Biological Process	IDA	PMID:11287421
GO:0007268	chemical synaptic transmission	Biological Process	TAS	PMID:11102480
GO:0008016	regulation of heart contraction	Biological Process	NAS	PMID:11747815
GO:0071456	cellular response to hypoxia	Biological Process	ISS	GO_REF:0000024
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098982	GABA-ergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099634	postsynaptic specialization membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000120
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0043197	dendritic spine	Cellular Component	IEA	GO_REF:0000120
GO:0043204	perikaryon	Cellular Component	IEA	GO_REF:0000044
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0045211	postsynaptic membrane	Cellular Component	IEA	GO_REF:0000120
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000120
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000120
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0032809	neuronal cell body membrane	Cellular Component	ISS	GO_REF:0000024
GO:0044853	plasma membrane raft	Cellular Component	ISS	GO_REF:0000024
GO:0071193	Kv4.2-KChIP2 channel complex	Cellular Component	IPI	PMID:14980201
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000120
GO:0005250	A-type (transient outward) potassium channel activity	Molecular Function	IEA	GO_REF:0000107
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:10551270

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