BFAR

Details:

UniProt Entry: Q9NZS9
Gene: BFAR
Class: RING
Family: RING9
Protein length: 450
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9NZS9
MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL
WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ
KYGNDQIPLA PNTGRANQQM GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA
KWTAEEVVLW LEQLGPWASL YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL
MELERVKALG VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LSLLYLYLFD YTDTFLPFIH
TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR
FLIINAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV STQGLFVAMF WPLIPQFVCN
CLFYWALYFN PIINIDLVVK ELRRLETQVL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
24	120	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
34	74	Domain	Zinc finger, RING-type	IPR001841	PS50089
34	73	Domain	Zinc finger, RING-type	IPR001841	SM00184
49	58	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
164	249	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	IPR013761	G3DSA:1.10.150.50
170	254	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	IPR013761	SSF47769
179	249	Domain	Sterile alpha motif domain	IPR001660	SM00454
181	247	Domain	Sterile alpha motif domain	IPR001660	PF00536
182	249	Domain	Sterile alpha motif domain	IPR001660	PS50105

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0036498	IRE1-mediated unfolded protein response	Biological Process	TAS	PMID:22013210
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA	PMID:10716992
GO:1903895	negative regulation of IRE1-mediated unfolded protein response	Biological Process	IDA	PMID:19328063
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:21068390
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:21068390
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:21068390
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:21068390
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:21068390
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005886	plasma membrane	Cellular Component	NAS	PMID:10716992
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21068390
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:10716992
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0089720	caspase binding	Molecular Function	IDA	PMID:10716992

Enzyme–Substrate Interactions ▾


P55061	BI1	Yes	Yes	No	No	—	No	E3-specific
P01135	TGFA	Yes	No	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P55061	BI1	Yes	Yes	No	No	—	No	E3-specific
P01135	TGFA	Yes	No	No	No	—	No	E3-specific