APC11

Details:

UniProt Entry: Q9NYG5
Gene: ANAPC11
Class: RING
Family: RING4
Protein length: 84
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2mt5, 4r2y, 4ui9, 5a31, 5g04, 5g05, 5jg6, 5khr, 5khu, 5l9t, 5l9u, 5lcw, 6q6g, 6q6h, 6tlj, 6tm5, 6tnt, 7qe7, 8pkp, 8tar, 8tau, 9gaw, 9n9r, 9n9s

Protein Sequence ▾

>Q9NYG5
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI
LKWLHAQQVQ QHCPMCRQEW KFKE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	84	Domain	Anaphase-promoting complex subunit 11, RING-H2 finger	IPR024991	PF12861
1	84	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
20	82	Domain	Anaphase-promoting complex subunit 11, RING-H2 finger	IPR024991	cd16456
34	77	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0051603	proteolysis involved in protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:39880951
GO:0000278	mitotic cell cycle	Biological Process	TAS	PMID:11739784
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051445	regulation of meiotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:29033132
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:18485873
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:29033132
GO:0005680	anaphase-promoting complex	Cellular Component	IEA	GO_REF:0000002
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-141423
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0097602	cullin family protein binding	Molecular Function	IEA	GO_REF:0000002
GO:0001664	G protein-coupled receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:10230407

Enzyme–Substrate Interactions ▾


O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q9NQW6	ANLN	Yes	Yes	No	No	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The E3 Ligome database, including all associated data, metadata, and documentation, is the intellectual property of Goethe University (PROXIDRUGs consortium) under the InnoDATA project.
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Prohibited Use

Use of the Database or any derivative works for commercial purposes without prior written consent from Dr. Ramachandra M. Bhaskara (Goethe University, Frankfurt and the PROXIDRUGs consortia).
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The sale, lease, license, or other transfer of DATA or MODIFICATIONS to a for-profit organization. COMMERCIAL PURPOSES shall also include uses of DATA or MODIFICATIONS by any other organization, including RECIPIENT, to perform contract research to screen E3–substrate networks and compound libraries, to manufacture products for general sale or to conduct research activities that result in any sale, lease, license, or transfer of DATA or MODIFICATIONS for-profit organization.

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The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
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Unless otherwise stated, the Human E3 Ligome Database and all associated data are licensed under the Creative Commons Attribution 4.0 International License ( CC BY-NC-SA 4.0).
Contributors must agree to license their contributions under the same CC BY-NC-SA 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta, A., Cristiani, A., Nikte, S.V. et al. Multi-scale classification decodes the complexity of the human E3 ligome. Nat Commun 16, 11382 (2025).

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q9NQW6	ANLN	Yes	Yes	No	No	—	No	E3-specific