APC11

Details:

UniProt Entry: Q9NYG5
Gene: ANAPC11
Class: RING
Family: RING4
Protein length: 84
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2mt5, 4r2y, 4ui9, 5a31, 5g04, 5g05, 5jg6, 5khr, 5khu, 5l9t, 5l9u, 5lcw, 6q6g, 6q6h, 6tlj, 6tm5, 6tnt, 7qe7

Protein Sequence ▾

>Q9NYG5
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI
LKWLHAQQVQ QHCPMCRQEW KFKE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	84	Domain	Anaphase-promoting complex subunit 11, RING-H2 finger	IPR024991	PF12861
1	84	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
20	82	Domain	Anaphase-promoting complex subunit 11, RING-H2 finger	IPR024991	cd16456
34	77	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0051603	proteolysis involved in protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:39880951
GO:0000278	mitotic cell cycle	Biological Process	TAS	PMID:11739784
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051445	regulation of meiotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:29033132
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:18485873
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:29033132
GO:0005680	anaphase-promoting complex	Cellular Component	IEA	GO_REF:0000002
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-141423
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0097602	cullin family protein binding	Molecular Function	IEA	GO_REF:0000002
GO:0001664	G protein-coupled receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:10230407

Enzyme–Substrate Interactions ▾


O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q9NQW6	ANLN	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q9NQW6	ANLN	Yes	Yes	No	No	—	No	E3-specific