KLH28

Details:

UniProt Entry: Q9NXS3
Gene: KLHL28
Class: Other E3 Components
Family: Adaptor
Protein length: 571
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NXS3
MDHTSPTYML ANLTHLHSEQ LLQGLNLLRQ HHELCDIILR VGDVKIHAHK VVLASVSPYF
KAMFTGNLSE KENSEVEFQC IDETALQAIV EYAYTGTVFI SQDTVESLLP AANLLQIKLV
LKECCAFLES QLDPGNCIGI SRFAETYGCR DLYLAATKYI CQNFEAVCQT EEFFELTHAD
LDEIVSNDCL NVATEETVFY ALESWIKYDV QERQKYLAQL LNSVRLPLLS VKFLTRLYEA
NHLIRDDRTC KHLLNEALKY HFMPEHRLSH QTVLMTRPRC APKVLCAVGG KSGLFACLDS
VEMYFPQNDS WIGLAPLNIP RYEFGICVLD QKVYVIGGIA TNVRPGVTIR KHENSVECWN
PDTNTWTSLE RMNESRSTLG VVVLAGELYA LGGYDGQSYL QSVEKYIPKI RKWQPVAPMT
TTRSCFAAAV LDGMIYAIGG YGPAHMNSVE RYDPSKDSWE MVASMADKRI HFGVGVMLGF
IFVVGGHNGV SHLSSIERYD PHQNQWTVCR PMKEPRTGVG AAVIDNYLYV VGGHSGSSYL
NTVQKYDPIS DTWLDSAGMI YCRCNFGLTA L

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	571	Family	BTB-kelch protein	IPR017096	PIRSF037037
9	133	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
16	130	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
25	131	Domain	BTB/POZ domain	IPR000210	PF00651
35	102	Domain	BTB/POZ domain	IPR000210	PS50097
35	132	Domain	BTB/POZ domain	IPR000210	SM00225
137	238	Domain	BTB/Kelch-associated	IPR011705	PF07707
137	239	Domain	BTB/Kelch-associated	IPR011705	SM00875
252	412	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
263	341	Homologous_superfamily	Galactose oxidase/kelch, beta-propeller	IPR011043	SSF50965
284	331	Repeat	Kelch repeat type 1	IPR006652	SM00612
320	373	Repeat	Kelch repeat type 1	IPR006652	PF01344
332	386	Repeat	Kelch repeat type 1	IPR006652	SM00612
354	571	Homologous_superfamily	Galactose oxidase/kelch, beta-propeller	IPR011043	SSF50965
376	419	Repeat	Kelch repeat type 1	IPR006652	PF01344
387	433	Repeat	Kelch repeat type 1	IPR006652	SM00612
413	571	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
423	465	Repeat	Kelch repeat type 1	IPR006652	PF01344
434	479	Repeat	Kelch repeat type 1	IPR006652	SM00612
469	512	Repeat	Kelch repeat type 1	IPR006652	PF01344
480	526	Repeat	Kelch repeat type 1	IPR006652	SM00612
515	553	Repeat	Kelch repeat type 1	IPR006652	PF01344
527	571	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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