FXL12

Details:

UniProt Entry: Q9NXK8
Gene: FBXL12
Class: Other E3 Components
Family: Receptor
Protein length: 326
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NXK8
MATLVELPDS VLLEIFSYLP VRDRIRISRV CHRWKRLVDD RWLWRHVDLT LYTMRPKVMW
HLLRRYMASR LHSLRMGGYL FSGSQAPQLS PALLRALGQK CPNLKRLCLH VADLSMVPIT
SLPSTLRTLE LHSCEISMAW LHKQQDPTVL PLLECIVLDR VPAFRDEHLQ GLTRFRALRS
LVLGGTYRVT ETGLDAGLQE LSYLQRLEVL GCTLSADSTL LAISRHLRDV RKIRLTVRGL
SAPGLAVLEG MPALESLCLQ GPLVTPEMPS PTEILSSCLT MPKLRVLELQ GLGWEGQEAE
KILCKGLPHC MVIVRACPKE SMDWWM

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	47	Domain	F-box domain	IPR001810	PS50181
2	323	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
3	109	Family	F-box only protein 33/F-box/LRR-repeat protein 12	IPR039940	PTHR20933
6	49	Domain	F-box domain	IPR001810	PF12937
6	39	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
7	46	Domain	F-box domain	IPR001810	SM00256

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:18660753

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