RN186

Details:

UniProt Entry: Q9NXI6
Gene: RNF186
Class: RING
Family: RING4
Protein length: 227
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9NXI6
MACTKTLQQS QPISAGATTT TTAVAPAGGH SGSTECDLEC LVCREPYSCP RLPKLLACQH
AFCAICLKLL LCVQDNTWSI TCPLCRKVTA VPGGLICSLR DHEAVVGQLA QPCTEVSLCP
QGLVDPADLA AGHPSLVGED GQDEVSANHV AARRLAAHLL LLALLIILIG PFIYPGVLRW
VLTFIIALAL LMSTLFCCLP STRGSCWPSS RTLFCREQKH SHISSIA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	107	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
40	86	Domain	Zinc finger, RING-type	IPR001841	PS50089
40	85	Domain	Zinc finger, RING-type	IPR001841	SM00184
58	67	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0140208	apoptotic process in response to mitochondrial fragmentation	Biological Process	IDA	PMID:29222049
GO:2000785	regulation of autophagosome assembly	Biological Process	IDA	PMID:33280498
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035519	protein K29-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070585	protein localization to mitochondrion	Biological Process	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	PMID:23896122
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:23896122
GO:0005515	protein binding	Molecular Function	IPI	PMID:23896122
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IDA	PMID:23896122
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P58004	SESN2	Yes	No	No	No	—	No	E3-specific

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