MARH5

Details:

UniProt Entry: Q9NX47
Gene: MARCHF5
Class: RING
Family: RING2
Protein length: 278
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9NX47
MPDQALQQML DRSCWVCFAT DEDDRTAEWV RPCRCRGSTK WVHQACLQRW VDEKQRGNST
ARVACPQCNA EYLIVFPKLG PVVYVLDLAD RLISKACPFA AAGIMVGSIY WTAVTYGAVT
VMQVVGHKEG LDVMERADPL FLLIGLPTIP VMLILGKMIR WEDYVLRLWR KYSNKLQILN
SIFPGIGCPV PRIPAEANPL ADHVSATRIL CGALVFPTIA TIVGKLMFSS VNSNLQRTIL
GGIAFVAIKG AFKVYFKQQQ YLRQAHRKIL NYPEQEEA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	74	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
6	75	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
13	69	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
14	68	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IDA	PMID:16125763
GO:0044546	NLRP3 inflammasome complex assembly	Biological Process	IDA	PMID:17483456
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:25636800
GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Biological Process	IDA	PMID:31189953
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0039532	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IDA	PMID:31881323
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:37575012
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:16874301
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:37916870
GO:0070585	protein localization to mitochondrion	Biological Process	IMP	PMID:17606867
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:31881323
GO:0090140	regulation of mitochondrial fission	Biological Process	IBA	GO_REF:0000033
GO:0090141	positive regulation of mitochondrial fission	Biological Process	IMP	PMID:20103533
GO:0141111	positive regulation of cGAS/STING signaling pathway	Biological Process	IDA	PMID:37916870
GO:0005741	mitochondrial outer membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005777	peroxisome	Cellular Component	IEA	GO_REF:0000043
GO:0005778	peroxisomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16874301
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0051020	GTPase binding	Molecular Function	IPI	PMID:16936636
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9Y3D6	FIS1	Yes	Yes	No	No	16874301	EBI-8588373	E3-specific
P46821	MAP1B	Yes	Yes	No	No	—	No	E3-specific
P33076	C2TA	Yes	Yes	No	No	—	No	Cluster-specific
P46939	UTRN	Yes	Yes	No	No	—	No	E3-specific
O00220	TR10A	Yes	Yes	No	No	—	No	E3-specific
Q9NX47	MARH5	Yes	Yes	No	No	—	No	E3-specific

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