IRAK4

>Q9NWZ3
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL
QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL LPDAVPKTAN TLPSKEAITV
QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS SSPENKSLEV SDTRFHSFSF YELKNVTNNF
DERPISVGGN KMGEGGFGVV YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC
QHENLVELLG FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL
RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND
ADSTSVEAMY SVASQCLHEK KNKRPDIKKV QQLLQEMTAS

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	459	Family	Interleukin-1 receptor-associated kinase 4	IPR017428	PIRSF038189
1	114	Homologous_superfamily	Death-like domain superfamily	IPR011029	SSF47986
1	113	Homologous_superfamily	Death-like domain superfamily	IPR011029	G3DSA:1.10.533.10
9	106	Domain	IRAK4, Death domain	IPR037970	cd08793
156	454	Homologous_superfamily	Protein kinase-like domain superfamily	IPR011009	SSF56112
186	454	Domain	Protein kinase domain	IPR000719	PS50011
186	458	Domain	Protein kinase domain	IPR000719	SM00220
190	454	Domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	IPR001245	PF07714

GO term	Name	Ontology	Evidence	Reference
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0007254	JNK cascade	Biological Process	IEA	GO_REF:0000107
GO:0031349	positive regulation of defense response	Biological Process	IEA	GO_REF:0000117
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000120
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:17878161
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:12048232
GO:0038172	interleukin-33-mediated signaling pathway	Biological Process	IDA	PMID:20532808
GO:0070498	interleukin-1-mediated signaling pathway	Biological Process	IDA	PMID:14625308
GO:0002224	toll-like receptor signaling pathway	Biological Process	TAS	PMID:21269878
GO:0002446	neutrophil mediated immunity	Biological Process	IMP	PMID:19663824
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process	TAS	PMID:21269878
GO:0008063	Toll signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0034162	toll-like receptor 9 signaling pathway	Biological Process	TAS	Reactome:R-HSA-168138
GO:0035556	intracellular signal transduction	Biological Process	IBA	GO_REF:0000033
GO:1990266	neutrophil migration	Biological Process	IMP	PMID:19663824
GO:0005615	extracellular space	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0009986	cell surface	Cellular Component	IDA	PMID:22851693
GO:0019897	extrinsic component of plasma membrane	Cellular Component	IC	PMID:20485341
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-166082
GO:0010008	endosome membrane	Cellular Component	TAS	Reactome:R-HSA-975100
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0004672	protein kinase activity	Molecular Function	IEA	GO_REF:0000002
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016301	kinase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0000287	magnesium ion binding	Molecular Function	IEA	GO_REF:0000002
GO:0005149	interleukin-1 receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:33238146
GO:0106310	protein serine kinase activity	Molecular Function	IEA	GO_REF:0000116

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4081711	ChEMBL	9.7	8CG	—	CC[C@@H]1[C@H](F)C(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12
E3 Binder	CHEMBL4290222	ChEMBL	7.03	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL388978	ChEMBL	8.77	STU	—	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
E3 Binder	CHEMBL4576489	ChEMBL	7.12	—	—	CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
E3 Binder	CHEMBL4465866	ChEMBL	7.64	—	—	CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
E3 Binder	CHEMBL210774	ChEMBL	6.0	—	—	C=CCn1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21
E3 Binder	CHEMBL4112117	ChEMBL	8.24	—	—	CC(=O)N1CC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL4108168	ChEMBL	8.1	—	—	CC(=O)N1CCC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1
E3 Binder	CHEMBL3586496	ChEMBL	6.75	—	—	CC(=O)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C)cc3)n2)CC1
E3 Binder	CHEMBL4113721	ChEMBL	6.35	—	—	CC(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL5283174	ChEMBL	7.77	—	—	CC(=O)N1CCC(n2cc(NC(=O)c3coc(-c4ccnc(C)c4)n3)c(C(N)=O)n2)CC1.Cl
E3 Binder	CHEMBL5207332	ChEMBL	8.7	—	—	CC(=O)N1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5284942	ChEMBL	7.92	—	—	CC(=O)N1CCC(n2cc(Nc3nc(NC4CCOCC4)c4nc(CC#N)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5272567	ChEMBL	8.52	—	—	CC(=O)N1CCC(n2cc(Nc3nc(OC4CCOCC4)c4nc(C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5277222	ChEMBL	7.5	—	—	CC(=O)N1CCC(n2cc(Nc3nc(OC4CCOCC4)c4nc(CC#N)ccc4n3)cn2)CC1
E3 Binder	CHEMBL4110921	ChEMBL	7.89	—	—	CC(=O)N1CCC2(CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)C2)C1
E3 Binder	CHEMBL4788568	ChEMBL	6.08	—	—	CC(=O)N1CCN([C@H]2CC[C@@H](Nc3ncnc4[nH]cc(C(C)C)c34)CC2)CC1
E3 Binder	CHEMBL4539647	ChEMBL	9.0	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL4080574	ChEMBL	8.7	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL4528699	ChEMBL	6.91	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL4278882	ChEMBL	7.66	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1
E3 Binder	CHEMBL4293607	ChEMBL	7.68	CKN	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc([C@H](C)CC(N)=O)c34)CC2)CC1
E3 Binder	CHEMBL4282348	ChEMBL	7.11	—	—	CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc([C@H]5CC[C@H](C(N)=O)CC5)c34)CC2)CC1
E3 Binder	CHEMBL4110865	ChEMBL	6.35	—	—	CC(=O)N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4109546	ChEMBL	8.54	—	—	CC(=O)N1CC[C@@H](Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL3907736	ChEMBL	8.48	—	—	CC(=O)NC1CCN(C(=O)c2nnc(-c3cnc(Nc4ccc5ncsc5c4)cc3NC(C)C)s2)C1
E3 Binder	CHEMBL4107689	ChEMBL	7.27	—	—	CC(=O)NC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4110923	ChEMBL	7.03	—	—	CC(=O)NC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3929809	ChEMBL	8.72	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3962798	ChEMBL	8.15	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL3958009	ChEMBL	8.03	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3978710	ChEMBL	8.31	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL3983043	ChEMBL	8.42	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3925644	ChEMBL	8.46	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL4754408	ChEMBL	8.43	—	—	CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc3sc(-c4cncs4)cc3c2NC(C)C)CC1
E3 Binder	CHEMBL3963886	ChEMBL	8.8	—	—	CC(=O)Nc1ccc(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)cc1
E3 Binder	CHEMBL4111696	ChEMBL	8.74	—	—	CC(=O)Nc1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1
E3 Binder	CHEMBL3753450	ChEMBL	6.37	—	—	CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C(F)(F)F)n3)ccc2n1
E3 Binder	CHEMBL4112370	ChEMBL	7.63	—	—	CC(=O)Nc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3949459	ChEMBL	8.17	—	—	CC(=O)OC(C)(C)C(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3688339	ChEMBL	6.71	OT5	—	CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1
E3 Binder	CHEMBL3735504	ChEMBL	9.47	—	—	CC(C)(C)C(=O)Nc1ccc2c(c1)nc(NC(=O)c1cccc(C(F)(F)F)c1)n2[C@H]1CC[C@@H](CO)CC1
E3 Binder	CHEMBL3735448	ChEMBL	6.82	—	—	CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2-c1ccc(CCCO)cc1
E3 Binder	CHEMBL1236126	ChEMBL	8.92	T12	—	CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2CCCO
E3 Binder	CHEMBL4114915	ChEMBL	8.24	—	—	CC(C)(C)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4112374	ChEMBL	8.66	—	—	CC(C)(C)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL3945366	ChEMBL	7.77	—	—	CC(C)(C)NC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4106804	ChEMBL	9.0	—	—	CC(C)(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107447	ChEMBL	8.77	—	—	CC(C)(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113532	ChEMBL	7.99	—	—	CC(C)(C)OC(=O)N1CC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL4113392	ChEMBL	7.57	—	—	CC(C)(C)OC(=O)N1CC2(CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)C1
E3 Binder	CHEMBL4114246	ChEMBL	6.27	—	—	CC(C)(C)c1cccc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL3958152	ChEMBL	7.31	—	—	CC(C)(CCO)Oc1cc2ncccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL4112662	ChEMBL	8.07	—	—	CC(C)(CN)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113240	ChEMBL	7.85	—	—	CC(C)(CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)OC(F)F
E3 Binder	CHEMBL4112958	ChEMBL	8.17	—	—	CC(C)(CNc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)OC(F)F
E3 Binder	CHEMBL4110079	ChEMBL	8.33	—	—	CC(C)(CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3910109	ChEMBL	8.47	—	—	CC(C)(F)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)(C)C
E3 Binder	CHEMBL4112418	ChEMBL	8.32	—	—	CC(C)(F)CCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110610	ChEMBL	8.28	—	—	CC(C)(F)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109952	ChEMBL	8.62	—	—	CC(C)(F)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4109209	ChEMBL	8.92	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(O)c1
E3 Binder	CHEMBL4106513	ChEMBL	7.87	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4111627	ChEMBL	8.6	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4112525	ChEMBL	8.6	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4112867	ChEMBL	8.52	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC3CC(CC(O)(C3)C1)C2
E3 Binder	CHEMBL4115485	ChEMBL	8.66	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4108814	ChEMBL	8.55	—	—	CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(C(F)F)c1
E3 Binder	CHEMBL4107316	ChEMBL	8.32	—	—	CC(C)(O)/C=C/Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3937950	ChEMBL	8.18	—	—	CC(C)(O)C(F)(F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4106539	ChEMBL	7.38	—	—	CC(C)(O)C1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4107887	ChEMBL	7.38	—	—	CC(C)(O)C1CN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4472406	ChEMBL	9.8	—	—	CC(C)(O)CCN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL3925564	ChEMBL	8.77	—	—	CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL3890249	ChEMBL	8.51	—	—	CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL3894977	ChEMBL	8.22	—	—	CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL3905839	ChEMBL	7.83	—	—	CC(C)(O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL3890485	ChEMBL	7.95	—	—	CC(C)(O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4647567	ChEMBL	8.0	—	—	CC(C)(O)CCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1
E3 Binder	CHEMBL4782801	ChEMBL	8.07	Y9T	—	CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL4800602	ChEMBL	6.77	—	—	CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)cc(C3CC3)c2n1
E3 Binder	CHEMBL4746921	ChEMBL	6.51	—	—	CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)cc(F)c2n1
E3 Binder	CHEMBL4112926	ChEMBL	8.59	—	—	CC(C)(O)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107696	ChEMBL	8.68	—	—	CC(C)(O)CNc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108237	ChEMBL	7.87	—	—	CC(C)(O)CNc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4645368	ChEMBL	8.03	—	—	CC(C)(O)[C@@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1
E3 Binder	CHEMBL4568894	ChEMBL	9.96	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(N4CC(F)(F)C4)CC3)cc2C1=O
E3 Binder	CHEMBL4556091	ChEMBL	10.59	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(N4CCC4)CC3)cc2C1=O
E3 Binder	CHEMBL4445098	ChEMBL	10.0	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(C4CC(F)(F)C4)CC3)cc2C1=O
E3 Binder	CHEMBL4566431	ChEMBL	10.11	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(C4COC4)CC3)cc2C1=O
E3 Binder	CHEMBL4545898	ChEMBL	10.09	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CC(F)F)CC3)cc2C1=O
E3 Binder	CHEMBL4475494	ChEMBL	9.72	QL7	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL4536154	ChEMBL	8.92	—	—	CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2S1(=O)=O
E3 Binder	CHEMBL4115333	ChEMBL	8.17	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(CO)CF
E3 Binder	CHEMBL4108089	ChEMBL	7.92	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC12CC3CC(CC(C3)C1)C2
E3 Binder	CHEMBL4107911	ChEMBL	8.92	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC12CCC(O)(CC1)C2
E3 Binder	CHEMBL4115586	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC(F)(F)C1
E3 Binder	CHEMBL4111587	ChEMBL	8.8	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4115463	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1c1c[nH]cn1
E3 Binder	CHEMBL4112434	ChEMBL	9.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(F)C1
E3 Binder	CHEMBL4110735	ChEMBL	8.52	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(N)C1
E3 Binder	CHEMBL4114212	ChEMBL	8.37	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(NCC(F)(F)F)C1
E3 Binder	CHEMBL4107813	ChEMBL	8.85	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(O)C1
E3 Binder	CHEMBL4108575	ChEMBL	9.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC1
E3 Binder	CHEMBL4108787	ChEMBL	8.28	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(CO)C1
E3 Binder	CHEMBL4108104	ChEMBL	8.36	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(F)(F)C1O
E3 Binder	CHEMBL4114980	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC1
E3 Binder	CHEMBL4109973	ChEMBL	8.8	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCOC1
E3 Binder	CHEMBL4108543	ChEMBL	8.77	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCN(S(C)(=O)=O)CC1
E3 Binder	CHEMBL4113871	ChEMBL	8.51	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCN(c2ccccc2)CC1
E3 Binder	CHEMBL4106870	ChEMBL	9.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4107284	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1F
E3 Binder	CHEMBL4113763	ChEMBL	8.52	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CN(S(C)(=O)=O)C1
E3 Binder	CHEMBL4111218	ChEMBL	8.7	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CN(c2ncc(F)cn2)C1
E3 Binder	CHEMBL4106613	ChEMBL	9.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4108188	ChEMBL	8.46	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1COCC1(F)F
E3 Binder	CHEMBL4109217	ChEMBL	8.64	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC(F)(F)F
E3 Binder	CHEMBL4106742	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1(F)CCC1
E3 Binder	CHEMBL4112750	ChEMBL	8.55	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1(O)CCC1
E3 Binder	CHEMBL4115525	ChEMBL	7.76	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1CCOCC1
E3 Binder	CHEMBL4111055	ChEMBL	8.43	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1COC1
E3 Binder	CHEMBL4115121	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCCC(F)(F)F
E3 Binder	CHEMBL4106614	ChEMBL	8.4	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCCN1CCOCC1
E3 Binder	CHEMBL4112912	ChEMBL	8.62	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4114949	ChEMBL	8.66	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCC[C@H]1O
E3 Binder	CHEMBL4112814	ChEMBL	8.54	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)CC#N)C1
E3 Binder	CHEMBL4113034	ChEMBL	8.39	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)CC(F)(F)F)C1
E3 Binder	CHEMBL4111288	ChEMBL	8.89	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(S(C)(=O)=O)C1
E3 Binder	CHEMBL4110783	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncc(F)cn2)C1
E3 Binder	CHEMBL4115090	ChEMBL	7.86	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCNC1
E3 Binder	CHEMBL4111861	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCOC1
E3 Binder	CHEMBL4108427	ChEMBL	8.31	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1COC[C@H]1F
E3 Binder	CHEMBL4115149	ChEMBL	8.66	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1COC[C@H]1O
E3 Binder	CHEMBL3984663	ChEMBL	8.52	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CCOC1
E3 Binder	CHEMBL4114114	ChEMBL	8.89	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@@](C)(O)CC1
E3 Binder	CHEMBL4106665	ChEMBL	8.92	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](C(N)=O)CC1
E3 Binder	CHEMBL4114551	ChEMBL	8.44	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@](C)(O)CC1
E3 Binder	CHEMBL4114306	ChEMBL	8.8	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1C[C@H](C(C)(C)O)C1
E3 Binder	CHEMBL4106842	ChEMBL	8.77	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(-n2cccn2)cc1
E3 Binder	CHEMBL4106687	ChEMBL	8.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(-n2ccnc2)cc1
E3 Binder	CHEMBL4113542	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(-n2cncn2)cc1
E3 Binder	CHEMBL4109312	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(C(N)=O)cc1
E3 Binder	CHEMBL4113337	ChEMBL	8.6	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2[nH]ncc2c1
E3 Binder	CHEMBL4112058	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2nc[nH]c2c1
E3 Binder	CHEMBL4110814	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2ncoc2c1
E3 Binder	CHEMBL4109550	ChEMBL	8.77	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2ncsc2c1
E3 Binder	CHEMBL4110300	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2nn[nH]c2c1
E3 Binder	CHEMBL4113582	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(-c2ncc[nH]2)c1
E3 Binder	CHEMBL4107134	ChEMBL	8.77	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1
E3 Binder	CHEMBL4108627	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1F
E3 Binder	CHEMBL4110867	ChEMBL	8.6	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C(N)=O)c1
E3 Binder	CHEMBL4110216	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(CO)c1
E3 Binder	CHEMBL4109266	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(NS(C)(=O)=O)c1
E3 Binder	CHEMBL4107137	ChEMBL	8.66	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(O)c1
E3 Binder	CHEMBL4107511	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(S(N)(=O)=O)c1
E3 Binder	CHEMBL4107855	ChEMBL	8.62	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cnn(C2CCOCC2)c1
E3 Binder	CHEMBL4115559	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)(F)F)c1
E3 Binder	CHEMBL4114139	ChEMBL	8.32	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C(N)=O)cnc32)cc1NC1CCC1
E3 Binder	CHEMBL4108062	ChEMBL	8.17	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C(N)=O)cnc32)cc1NCC1CNC1
E3 Binder	CHEMBL4113223	ChEMBL	8.28	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4113064	ChEMBL	8.47	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCC1
E3 Binder	CHEMBL4113144	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4114107	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CC1
E3 Binder	CHEMBL4112273	ChEMBL	8.7	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4112848	ChEMBL	8.35	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1CCC1
E3 Binder	CHEMBL4112539	ChEMBL	8.13	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4113330	ChEMBL	7.9	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4110222	ChEMBL	8.24	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(C(F)F)c1
E3 Binder	CHEMBL4109866	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4112745	ChEMBL	8.0	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4113207	ChEMBL	8.11	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(C(F)F)c1
E3 Binder	CHEMBL4107445	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)(F)F)c1
E3 Binder	CHEMBL4110464	ChEMBL	8.89	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4115117	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CCC#N)c1
E3 Binder	CHEMBL4109034	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CCCF)c1
E3 Binder	CHEMBL4108474	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC12CC(C1)C2
E3 Binder	CHEMBL4115542	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC12CC3CC(CC(O)(C3)C1)C2
E3 Binder	CHEMBL4110746	ChEMBL	8.47	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1CC1
E3 Binder	CHEMBL4111872	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC(C1)C2
E3 Binder	CHEMBL4110124	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC3CC(CC(O)(C3)C1)C2
E3 Binder	CHEMBL4111058	ChEMBL	8.55	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CCC(O)(CC1)C2
E3 Binder	CHEMBL4113934	ChEMBL	8.37	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CC(F)(F)C1
E3 Binder	CHEMBL4110250	ChEMBL	8.54	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4108659	ChEMBL	8.64	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)(F)C1
E3 Binder	CHEMBL4110840	ChEMBL	8.96	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)C1
E3 Binder	CHEMBL4109402	ChEMBL	8.52	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)CC1
E3 Binder	CHEMBL4109707	ChEMBL	8.49	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(N)C1
E3 Binder	CHEMBL4112884	ChEMBL	8.35	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC1
E3 Binder	CHEMBL4108784	ChEMBL	8.19	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCCOC1
E3 Binder	CHEMBL4112812	ChEMBL	8.4	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCN(c2ccccc2)CC1
E3 Binder	CHEMBL4108818	ChEMBL	8.52	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCN(c2ncc(F)cn2)CC1
E3 Binder	CHEMBL4115033	ChEMBL	8.66	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4107090	ChEMBL	7.84	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CN(c2ncc(Cl)cn2)C1
E3 Binder	CHEMBL4106523	ChEMBL	8.2	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CN(c2ncc(F)cn2)C1
E3 Binder	CHEMBL4114375	ChEMBL	8.43	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4106712	ChEMBL	8.26	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COCC1(F)F
E3 Binder	CHEMBL4115086	ChEMBL	7.97	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC(C)(C)N1CCOCC1
E3 Binder	CHEMBL4112724	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC(F)(F)C(C)(C)O
E3 Binder	CHEMBL4108994	ChEMBL	7.92	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC(F)(F)F
E3 Binder	CHEMBL4112231	ChEMBL	7.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC(F)F
E3 Binder	CHEMBL4115287	ChEMBL	8.08	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC1(F)CCC1
E3 Binder	CHEMBL4113245	ChEMBL	8.12	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC1CC1
E3 Binder	CHEMBL4111939	ChEMBL	8.3	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCC(F)(F)F
E3 Binder	CHEMBL4108324	ChEMBL	8.28	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCCF
E3 Binder	CHEMBL4107060	ChEMBL	7.86	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCNC(=O)OC(C)(C)C(F)(F)F
E3 Binder	CHEMBL4112120	ChEMBL	8.01	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCNS(C)(=O)=O
E3 Binder	CHEMBL4109694	ChEMBL	7.78	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCOC(F)F
E3 Binder	CHEMBL4115545	ChEMBL	7.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCc1cocn1
E3 Binder	CHEMBL4106997	ChEMBL	8.02	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)c2ccc(F)cc2F)C1
E3 Binder	CHEMBL4108248	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncc(F)cn2)C1
E3 Binder	CHEMBL4108523	ChEMBL	8.17	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncccn2)C1
E3 Binder	CHEMBL4111056	ChEMBL	8.39	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCOC1
E3 Binder	CHEMBL3982186	ChEMBL	8.32	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1C[C@H]1CO
E3 Binder	CHEMBL3891037	ChEMBL	7.99	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CCN(c2ncc(F)cn2)C1
E3 Binder	CHEMBL3965205	ChEMBL	8.06	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CCOC1
E3 Binder	CHEMBL4115045	ChEMBL	8.4	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@@](C)(O)CC1
E3 Binder	CHEMBL4112293	ChEMBL	8.4	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL4107389	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)C(F)F)CC1
E3 Binder	CHEMBL4114030	ChEMBL	8.28	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)C2CC2)CC1
E3 Binder	CHEMBL4112863	ChEMBL	8.41	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)c2ccccc2F)CC1
E3 Binder	CHEMBL4113585	ChEMBL	8.28	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC2COC2)CC1
E3 Binder	CHEMBL4115100	ChEMBL	8.62	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](O)CC1
E3 Binder	CHEMBL4114343	ChEMBL	7.9	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@](C)(O)CC1
E3 Binder	CHEMBL4114476	ChEMBL	8.44	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cc(-c2ccccc2)n[nH]1
E3 Binder	CHEMBL4112384	ChEMBL	8.96	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cc(C2CC2)n[nH]1
E3 Binder	CHEMBL4107103	ChEMBL	8.43	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc(-n2cncn2)cc1
E3 Binder	CHEMBL4111578	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc(C#N)cc1
E3 Binder	CHEMBL4113432	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc2ncsc2c1
E3 Binder	CHEMBL4114850	ChEMBL	8.59	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1
E3 Binder	CHEMBL4108684	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1F
E3 Binder	CHEMBL4107994	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccn(CC(F)(F)F)n1
E3 Binder	CHEMBL4110422	ChEMBL	8.51	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccn(CC(F)F)n1
E3 Binder	CHEMBL4109069	ChEMBL	8.8	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(-c2ncc(F)cn2)c1
E3 Binder	CHEMBL4107792	ChEMBL	8.82	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(-c2ncccn2)c1
E3 Binder	CHEMBL4110171	ChEMBL	8.48	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(C2CCOCC2)c1
E3 Binder	CHEMBL4107087	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(C2COC2)c1
E3 Binder	CHEMBL4109434	ChEMBL	8.77	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)(F)F)c1
E3 Binder	CHEMBL4111280	ChEMBL	8.89	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4111974	ChEMBL	8.68	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CCC#N)c1
E3 Binder	CHEMBL4108464	ChEMBL	8.62	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CCCF)c1
E3 Binder	CHEMBL4113747	ChEMBL	9.05	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(S(C)(=O)=O)c1
E3 Binder	CHEMBL4110605	ChEMBL	8.8	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C(N)=O)cnc32)cc1Nc1ccc2ncoc2c1
E3 Binder	CHEMBL4107169	ChEMBL	8.51	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4107578	ChEMBL	8.35	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4115046	ChEMBL	7.9	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1NC1COC1
E3 Binder	CHEMBL3951794	ChEMBL	8.16	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1N[C@@H]1C[C@H]1CO
E3 Binder	CHEMBL4108001	ChEMBL	8.19	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(C2CCOCC2)c1
E3 Binder	CHEMBL4115019	ChEMBL	8.72	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)(F)F)c1
E3 Binder	CHEMBL4106743	ChEMBL	8.64	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4109280	ChEMBL	8.57	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CCC#N)c1
E3 Binder	CHEMBL4111498	ChEMBL	8.89	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CCCF)c1
E3 Binder	CHEMBL4113637	ChEMBL	8.02	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4113443	ChEMBL	8.47	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCC(F)C1
E3 Binder	CHEMBL4113269	ChEMBL	8.05	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCC(O)C1
E3 Binder	CHEMBL4110283	ChEMBL	7.78	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCCOC1
E3 Binder	CHEMBL4110170	ChEMBL	7.9	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL4111375	ChEMBL	7.99	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1COC1
E3 Binder	CHEMBL4109920	ChEMBL	8.64	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4107673	ChEMBL	8.16	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cncnc32)cc1NC1CC1
E3 Binder	CHEMBL4113091	ChEMBL	7.96	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(N2CCc3cc(C#N)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4111891	ChEMBL	7.78	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(N2CCc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL3352825	ChEMBL	8.25	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3cnccc3n2)cc1NC1CC1
E3 Binder	CHEMBL4642013	ChEMBL	8.62	R7S	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1
E3 Binder	CHEMBL3353191	ChEMBL	8.74	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ncc(C#N)cc2Cl)cc1NC1CC1
E3 Binder	CHEMBL5094956	ChEMBL	8.7	—	—	CC(C)(O)[C@H](F)CNC(=O)c1cnc2c([nH]c3cc(C#N)ccc32)c1NC1CCC1
E3 Binder	CHEMBL3919364	ChEMBL	8.25	—	—	CC(C)(O)[C@H]1CCC[C@@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL3908153	ChEMBL	8.82	—	—	CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3977557	ChEMBL	8.34	—	—	CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(F)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3976033	ChEMBL	8.15	—	—	CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC2COC2)CC1
E3 Binder	CHEMBL3918080	ChEMBL	8.07	—	—	CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2Nc2cnn(CC(F)F)c2)CC1
E3 Binder	CHEMBL3943289	ChEMBL	8.21	—	—	CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(Cl)cnc43)cc2NC2COC2)CC1
E3 Binder	CHEMBL3980538	ChEMBL	8.55	—	—	CC(C)(O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL3930748	ChEMBL	8.48	—	—	CC(C)(O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL3929267	ChEMBL	7.19	—	—	CC(C)(O)[C@H]1C[C@@H](Nc2nc(NC3CCC3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL4576141	ChEMBL	8.14	—	—	CC(C)(O)[C@]1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4799896	ChEMBL	7.43	—	—	CC(C)(O)c1cc2nn(C3CN(C(=O)CC#N)C3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1
E3 Binder	CHEMBL4777489	ChEMBL	7.97	—	—	CC(C)(O)c1cc2nn(C3CNC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1
E3 Binder	CHEMBL4761337	ChEMBL	7.33	—	—	CC(C)(O)c1cc2nn(C[C@@H]3CCC(=O)N3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1
E3 Binder	CHEMBL4110722	ChEMBL	8.8	—	—	CC(C)(O)c1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1
E3 Binder	CHEMBL4111235	ChEMBL	8.46	—	—	CC(C)(O)c1cnc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)s1
E3 Binder	CHEMBL4111216	ChEMBL	7.81	—	—	CC(C)C(O)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115550	ChEMBL	7.76	—	—	CC(C)C(O)CNc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107848	ChEMBL	8.64	—	—	CC(C)CC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4114914	ChEMBL	7.77	—	—	CC(C)CC(=O)NCc1cnc2c(cnn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4112226	ChEMBL	8.23	—	—	CC(C)CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3960922	ChEMBL	7.96	—	—	CC(C)CC(O)[C@H](C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113859	ChEMBL	8.46	—	—	CC(C)CCC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3907387	ChEMBL	8.46	—	—	CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C
E3 Binder	CHEMBL3980604	ChEMBL	8.47	—	—	CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1COC1
E3 Binder	CHEMBL3924274	ChEMBL	8.35	—	—	CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3956976	ChEMBL	8.29	—	—	CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL3922192	ChEMBL	8.25	—	—	CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H](C)CO
E3 Binder	CHEMBL4112445	ChEMBL	8.49	—	—	CC(C)CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL5083433	ChEMBL	8.82	—	—	CC(C)CCn1cc(-c2cnc3c([nH]c4cc(C#N)ccc43)c2NC(C)C)nn1
E3 Binder	CHEMBL3938766	ChEMBL	8.21	—	—	CC(C)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4112197	ChEMBL	8.24	—	—	CC(C)COC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3586508	ChEMBL	7.89	4GF	—	CC(C)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C4CC4)cc3F)n2)CC1
E3 Binder	CHEMBL4115260	ChEMBL	6.18	—	—	CC(C)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4111430	ChEMBL	8.09	—	—	CC(C)NC(=O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4114127	ChEMBL	8.0	—	—	CC(C)NC(=O)[C@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108546	ChEMBL	8.19	—	—	CC(C)NC(=O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1
E3 Binder	CHEMBL3932942	ChEMBL	7.95	—	—	CC(C)NC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4761304	ChEMBL	6.34	—	—	CC(C)NC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL5088802	ChEMBL	8.82	—	—	CC(C)Nc1c(-c2cn(C3CCNCC3)nn2)cnc2c1[nH]c1cc(C#N)ccc12
E3 Binder	CHEMBL4789541	ChEMBL	8.28	—	—	CC(C)Nc1c(-c2cn(CCCO)nn2)cnc2sc(-c3ccc(=O)[nH]c3)cc12
E3 Binder	CHEMBL4761018	ChEMBL	8.64	—	—	CC(C)Nc1c(-c2cn(CCCO)nn2)cnc2sc(-c3cncs3)cc12
E3 Binder	CHEMBL5074470	ChEMBL	8.72	—	—	CC(C)Nc1c(C(=O)NCCC2CCNC2)cnc2c1[nH]c1cc(C#N)ccc12
E3 Binder	CHEMBL5082351	ChEMBL	8.7	—	—	CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2c1[nH]c1cc(C#N)ccc12
E3 Binder	CHEMBL4762550	ChEMBL	8.42	—	—	CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccc(=O)[nH]c3)cc12
E3 Binder	CHEMBL4756721	ChEMBL	8.32	—	—	CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccncc3)cc12
E3 Binder	CHEMBL4749904	ChEMBL	8.62	—	—	CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cn[nH]c3)cc12
E3 Binder	CHEMBL4106933	ChEMBL	7.88	—	—	CC(C)Nc1cc(-n2ccc(-c3ccnnc3)n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109437	ChEMBL	8.48	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)ccc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3964745	ChEMBL	8.0	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)ccc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL3986164	ChEMBL	7.83	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC12CCC(O)(CC1)C2
E3 Binder	CHEMBL3914855	ChEMBL	8.41	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCC(C(C)(O)C2CC2)CC1
E3 Binder	CHEMBL3925452	ChEMBL	8.39	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCC2(CC1)NC(=O)NC2=O
E3 Binder	CHEMBL3900602	ChEMBL	8.28	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(C[SH](=O)=O)CC1
E3 Binder	CHEMBL3906640	ChEMBL	7.88	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCc2nc(N)sc2C1
E3 Binder	CHEMBL3931002	ChEMBL	8.64	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(=O)N1CCN(C)CC1
E3 Binder	CHEMBL3921524	ChEMBL	8.55	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(=O)NC1CCS(=O)(=O)C1
E3 Binder	CHEMBL3975254	ChEMBL	8.74	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1(O)COC1
E3 Binder	CHEMBL3965584	ChEMBL	8.77	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL3977494	ChEMBL	8.7	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCCC1
E3 Binder	CHEMBL3947682	ChEMBL	8.26	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCCOC(C)(C)C
E3 Binder	CHEMBL3908695	ChEMBL	8.25	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCCOC(C)C
E3 Binder	CHEMBL3922141	ChEMBL	8.12	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNC(=O)C(C)(C)O
E3 Binder	CHEMBL3907139	ChEMBL	8.28	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(=O)(=O)N1CCOCC1
E3 Binder	CHEMBL3946114	ChEMBL	8.39	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(C)(=O)=O
E3 Binder	CHEMBL3914563	ChEMBL	8.57	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1
E3 Binder	CHEMBL4109047	ChEMBL	8.12	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113092	ChEMBL	8.64	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)NC(C)C
E3 Binder	CHEMBL4109646	ChEMBL	8.85	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)O
E3 Binder	CHEMBL3947755	ChEMBL	8.59	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@H](F)C(C)(C)O
E3 Binder	CHEMBL4110687	ChEMBL	8.26	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@@H]1CC=C(c2ccncc2)CC1
E3 Binder	CHEMBL3945800	ChEMBL	8.74	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@@](F)(c2nccn2C)CC1
E3 Binder	CHEMBL3895223	ChEMBL	8.72	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(=O)NC(C)C)CC1
E3 Binder	CHEMBL3926706	ChEMBL	8.7	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(=O)NC2CC2)CC1
E3 Binder	CHEMBL3984250	ChEMBL	8.43	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)C1
E3 Binder	CHEMBL3904136	ChEMBL	8.85	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL3958699	ChEMBL	8.48	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](O)CC1
E3 Binder	CHEMBL3947754	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](S(C)(=O)=O)CC1
E3 Binder	CHEMBL3970825	ChEMBL	8.29	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H]([N+](=O)[O-])CC1
E3 Binder	CHEMBL3911745	ChEMBL	8.34	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](C)(O)CC1
E3 Binder	CHEMBL3893606	ChEMBL	8.48	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2ccnn2C)CC1
E3 Binder	CHEMBL3982704	ChEMBL	8.37	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2nccn2C)CC1
E3 Binder	CHEMBL3912832	ChEMBL	8.28	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2nccs2)CC1
E3 Binder	CHEMBL3899111	ChEMBL	8.43	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccccn2)CC1
E3 Binder	CHEMBL3969520	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2cccnc2)CC1
E3 Binder	CHEMBL3974716	ChEMBL	8.55	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccncc2)CC1
E3 Binder	CHEMBL3940719	ChEMBL	8.64	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccnn2C)CC1
E3 Binder	CHEMBL3898331	ChEMBL	8.19	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2nccn2C)CC1
E3 Binder	CHEMBL3921623	ChEMBL	8.3	—	—	CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2nccs2)CC1
E3 Binder	CHEMBL4107960	ChEMBL	7.87	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)C4CC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113687	ChEMBL	7.98	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)C4CCOC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115268	ChEMBL	8.57	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC(C)(C)C)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110685	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC(C)(C)O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110095	ChEMBL	8.37	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC4CCCC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4106835	ChEMBL	8.27	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC4CCCCC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107475	ChEMBL	7.85	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC4CCOCC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107665	ChEMBL	8.66	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)Cc4ccccc4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4114411	ChEMBL	8.09	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)NCc4ccccc4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4114483	ChEMBL	8.32	—	—	CC(C)Nc1cc(-n2ccc3cc(CNC(=O)OC(C)C)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4114474	ChEMBL	7.93	—	—	CC(C)Nc1cc(-n2ccc3cc(Cl)ccc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115627	ChEMBL	8.82	—	—	CC(C)Nc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115151	ChEMBL	8.8	—	—	CC(C)Nc1cc(-n2ccc3cc(F)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110704	ChEMBL	8.37	—	—	CC(C)Nc1cc(-n2ccc3cccnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107163	ChEMBL	8.47	—	—	CC(C)Nc1cc(-n2ccc3cnc(N(C)C)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4111162	ChEMBL	8.89	—	—	CC(C)Nc1cc(-n2ccc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108854	ChEMBL	8.33	—	—	CC(C)Nc1cc(-n2ccc3cnc(N4CC[C@@H](O)C4)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3949060	ChEMBL	8.32	—	—	CC(C)Nc1cc(-n2ccc3cnc(N4CC[C@H](O)C4)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4106447	ChEMBL	8.72	—	—	CC(C)Nc1cc(-n2ccc3cnc(NCC(C)(C)O)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4106756	ChEMBL	8.77	—	—	CC(C)Nc1cc(-n2ccc3cnc(NCCO)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3969623	ChEMBL	8.38	—	—	CC(C)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL4110834	ChEMBL	8.96	—	—	CC(C)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109597	ChEMBL	8.72	—	—	CC(C)Nc1cc(-n2cnc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113524	ChEMBL	8.06	—	—	CC(C)Nc1cc(-n2cnc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F
E3 Binder	CHEMBL4115184	ChEMBL	8.4	—	—	CC(C)Nc1cc(-n2cnc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4111656	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2cnc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F
E3 Binder	CHEMBL4113937	ChEMBL	8.43	—	—	CC(C)Nc1cc(-n2cnc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109831	ChEMBL	8.6	—	—	CC(C)Nc1cc(-n2cnc3cnc(NCCO)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115670	ChEMBL	7.82	—	—	CC(C)Nc1cc(-n2cnc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4106606	ChEMBL	8.38	—	—	CC(C)Nc1cc(-n2ncc3cc(Br)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3892469	ChEMBL	8.17	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC1(C)CC1
E3 Binder	CHEMBL3893544	ChEMBL	7.96	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC1C=CCC1
E3 Binder	CHEMBL3978447	ChEMBL	8.18	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC1CCCCC1
E3 Binder	CHEMBL3953652	ChEMBL	7.87	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NCC1CC1C(C)(C)O
E3 Binder	CHEMBL3976685	ChEMBL	8.7	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NCCC(C)(C)F
E3 Binder	CHEMBL3985063	ChEMBL	8.2	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NCCC1CC1
E3 Binder	CHEMBL4108625	ChEMBL	8.0	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](C)F
E3 Binder	CHEMBL4109739	ChEMBL	8.72	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F
E3 Binder	CHEMBL4109233	ChEMBL	8.89	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4111880	ChEMBL	7.76	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)N[C@H](C)C1CC1
E3 Binder	CHEMBL3977923	ChEMBL	7.73	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(C(=O)C(C)C)CC1
E3 Binder	CHEMBL3958341	ChEMBL	8.0	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(C(=O)C2CN(S(C)(=O)=O)C2)CC1
E3 Binder	CHEMBL3966110	ChEMBL	8.29	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(S(=O)(=O)C(C)C)CC1
E3 Binder	CHEMBL3917045	ChEMBL	7.74	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(S(=O)(=O)NC(C)C)CC1
E3 Binder	CHEMBL3946151	ChEMBL	7.8	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(c2ncccn2)CC1
E3 Binder	CHEMBL3894101	ChEMBL	8.04	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCc2nc(N)sc2C1
E3 Binder	CHEMBL3954542	ChEMBL	7.84	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(=O)N1CCOCC1
E3 Binder	CHEMBL3986395	ChEMBL	7.98	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)(F)C(C)(C)O
E3 Binder	CHEMBL3938709	ChEMBL	7.87	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)=C1CCOCC1
E3 Binder	CHEMBL3951199	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1(O)COC1
E3 Binder	CHEMBL3950330	ChEMBL	8.31	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1CCOCC1
E3 Binder	CHEMBL3894314	ChEMBL	7.82	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC1CCS(=O)(=O)C1
E3 Binder	CHEMBL3898994	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(=O)N1CCN(C)CC1
E3 Binder	CHEMBL3891636	ChEMBL	8.32	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)NS(C)(=O)=O
E3 Binder	CHEMBL3923273	ChEMBL	8.19	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL3920766	ChEMBL	7.89	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(F)F
E3 Binder	CHEMBL3922475	ChEMBL	8.62	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)NS(C)(=O)=O
E3 Binder	CHEMBL3916358	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CC1
E3 Binder	CHEMBL3927317	ChEMBL	8.23	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCC(C)(O)CC1
E3 Binder	CHEMBL3902784	ChEMBL	8.19	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCC(F)(F)CC1
E3 Binder	CHEMBL3922334	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCCC1
E3 Binder	CHEMBL3932579	ChEMBL	8.08	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCN(C)CC1
E3 Binder	CHEMBL3983180	ChEMBL	8.07	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCN(C2COC2)CC1
E3 Binder	CHEMBL3940416	ChEMBL	8.12	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCNC1
E3 Binder	CHEMBL3944351	ChEMBL	8.17	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCOC1
E3 Binder	CHEMBL3925280	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCOCC1
E3 Binder	CHEMBL3952777	ChEMBL	8.39	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CC1
E3 Binder	CHEMBL3953023	ChEMBL	8.19	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCCCO1
E3 Binder	CHEMBL3931392	ChEMBL	8.59	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCN(C)CC1
E3 Binder	CHEMBL3986782	ChEMBL	8.35	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCOCC1
E3 Binder	CHEMBL3955569	ChEMBL	7.79	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCCN1CCOCC1
E3 Binder	CHEMBL3956279	ChEMBL	7.83	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCCc1ncn[nH]1
E3 Binder	CHEMBL3942383	ChEMBL	8.31	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCN1CCOCC1
E3 Binder	CHEMBL3947585	ChEMBL	8.09	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCN1CCS(=O)(=O)CC1
E3 Binder	CHEMBL3943142	ChEMBL	7.83	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCNS(C)(=O)=O
E3 Binder	CHEMBL3955423	ChEMBL	8.33	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1c[nH]cn1
E3 Binder	CHEMBL3986533	ChEMBL	8.48	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(F)cc1
E3 Binder	CHEMBL3923791	ChEMBL	8.44	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(N(C[SH](=O)=O)S(C)(=O)=O)cc1
E3 Binder	CHEMBL3890756	ChEMBL	8.51	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1
E3 Binder	CHEMBL3949690	ChEMBL	8.33	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1cccnc1
E3 Binder	CHEMBL3954452	ChEMBL	8.6	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccncc1
E3 Binder	CHEMBL4115604	ChEMBL	8.05	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(=O)N1CCN(S(C)(=O)=O)CC1
E3 Binder	CHEMBL4110754	ChEMBL	7.83	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(=O)N1CCOCC1
E3 Binder	CHEMBL3911443	ChEMBL	7.87	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(=O)N[C@@H](C)CO
E3 Binder	CHEMBL4111152	ChEMBL	8.52	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F
E3 Binder	CHEMBL3948538	ChEMBL	8.59	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109109	ChEMBL	7.86	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)OC(F)F
E3 Binder	CHEMBL4110998	ChEMBL	7.83	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)OP(=O)(O)O
E3 Binder	CHEMBL4111593	ChEMBL	8.04	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)C
E3 Binder	CHEMBL4112547	ChEMBL	7.97	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(O)(C1CC1)C1CC1
E3 Binder	CHEMBL4115189	ChEMBL	8.64	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(O)C(C)C
E3 Binder	CHEMBL3933351	ChEMBL	7.98	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@H](F)C(C)(C)O
E3 Binder	CHEMBL3898909	ChEMBL	8.35	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCc1nc(Cc2ccccc2)no1
E3 Binder	CHEMBL3923081	ChEMBL	7.76	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCc1nn[nH]n1
E3 Binder	CHEMBL4111238	ChEMBL	7.8	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@@H]1CCCN(S(C)(=O)=O)C1
E3 Binder	CHEMBL4108191	ChEMBL	8.15	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@@H]1CC[C@@H](C(C)(C)O)OC1
E3 Binder	CHEMBL3962443	ChEMBL	7.7	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CCCN(S(C)(=O)=O)C1
E3 Binder	CHEMBL3908035	ChEMBL	8.2	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)C1
E3 Binder	CHEMBL3985561	ChEMBL	8.85	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL4108032	ChEMBL	8.09	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NC(=O)[C@@H](C)O)CC1
E3 Binder	CHEMBL3903828	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NC(=O)[C@H](C)O)CC1
E3 Binder	CHEMBL3916631	ChEMBL	8.34	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NS(C)(=O)=O)CC1
E3 Binder	CHEMBL3953510	ChEMBL	8.17	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](S(C)(=O)=O)CC1
E3 Binder	CHEMBL3910394	ChEMBL	8.4	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cc2cc[nH]c2cn1
E3 Binder	CHEMBL3900741	ChEMBL	7.94	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(C(C)(C)O)cn1
E3 Binder	CHEMBL3954291	ChEMBL	8.17	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(CN2CCOCC2)cc1
E3 Binder	CHEMBL3900811	ChEMBL	8.16	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N(C)C)nc1
E3 Binder	CHEMBL3970192	ChEMBL	8.14	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCN(C)CC2)cn1
E3 Binder	CHEMBL3895880	ChEMBL	8.28	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCNCC2)nc1
E3 Binder	CHEMBL3923977	ChEMBL	8.29	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)cc1
E3 Binder	CHEMBL3973052	ChEMBL	8.08	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)cn1
E3 Binder	CHEMBL3905289	ChEMBL	8.35	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)nc1
E3 Binder	CHEMBL3942281	ChEMBL	7.81	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(O)cn1
E3 Binder	CHEMBL3901331	ChEMBL	8.04	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(OCCN(C)C)cn1
E3 Binder	CHEMBL3938325	ChEMBL	8.17	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnc(N2CCOCC2)nc1
E3 Binder	CHEMBL3936270	ChEMBL	7.8	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(C2CCOCC2)c1
E3 Binder	CHEMBL3932554	ChEMBL	8.11	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(C2CN(S(C)(=O)=O)C2)c1
E3 Binder	CHEMBL3973484	ChEMBL	7.97	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(C2COC2)c1
E3 Binder	CHEMBL3967229	ChEMBL	7.97	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(CC(C)(C)O)c1
E3 Binder	CHEMBL3946848	ChEMBL	8.0	—	—	CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4112067	ChEMBL	7.85	—	—	CC(C)Nc1cc(-n2ncc3cc(C(F)F)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4112570	ChEMBL	8.39	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3927743	ChEMBL	8.2	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NCC(F)C1(O)COC1
E3 Binder	CHEMBL3907661	ChEMBL	7.92	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NCCN1CCOCC1
E3 Binder	CHEMBL4111778	ChEMBL	8.37	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F
E3 Binder	CHEMBL4109623	ChEMBL	8.57	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3948919	ChEMBL	8.05	—	—	CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL4111435	ChEMBL	8.28	—	—	CC(C)Nc1cc(-n2ncc3cc(F)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4111012	ChEMBL	8.51	—	—	CC(C)Nc1cc(-n2ncc3cc(O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4106938	ChEMBL	8.41	—	—	CC(C)Nc1cc(-n2ncc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109992	ChEMBL	7.73	—	—	CC(C)Nc1cc(-n2ncc3cnc(NC[C@@H](F)C(C)(C)O)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108811	ChEMBL	8.21	—	—	CC(C)Nc1cc(-n2ncc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107885	ChEMBL	8.0	—	—	CC(C)Nc1cc(N2CCc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3917340	ChEMBL	7.64	—	—	CC(C)Nc1cc(Nc2ccc(C#N)cc2)ncc1-c1nnc(NC[C@@H](F)CO)o1
E3 Binder	CHEMBL3892422	ChEMBL	6.09	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1ccc2cn[nH]c2c1
E3 Binder	CHEMBL3894727	ChEMBL	6.24	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)N2CCC3(CC2)C(=O)NCN3c2ccccc2)cs1
E3 Binder	CHEMBL3963873	ChEMBL	6.12	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)N2CCN(c3ccc(F)cc3F)CC2)cs1
E3 Binder	CHEMBL3921439	ChEMBL	6.1	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)NCC2CCCCC2)cs1
E3 Binder	CHEMBL3984346	ChEMBL	7.62	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)NCC2CCCO2)cs1
E3 Binder	CHEMBL3905639	ChEMBL	8.51	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)NCCCN2CCCC2)cs1
E3 Binder	CHEMBL3936414	ChEMBL	7.58	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)NC[C@H](O)c2ccccc2)cs1
E3 Binder	CHEMBL3913888	ChEMBL	8.57	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(N)=O)co1
E3 Binder	CHEMBL3968119	ChEMBL	6.17	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(-c2ccc(F)c(S(=O)(=O)NC(C)(C)C)c2)o1
E3 Binder	CHEMBL3906831	ChEMBL	6.25	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(-c2cccc(C(N)=O)c2)o1
E3 Binder	CHEMBL3939893	ChEMBL	7.64	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(C(=O)N2CCC(N)CC2)o1
E3 Binder	CHEMBL3934248	ChEMBL	8.55	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(C(=O)N2CCC(O)C2)s1
E3 Binder	CHEMBL3353196	ChEMBL	8.55	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(C(=O)N2CC[C@H](O)C2)s1
E3 Binder	CHEMBL3947284	ChEMBL	7.66	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(N2CCN(CCN3CCOCC3)CC2)o1
E3 Binder	CHEMBL3973407	ChEMBL	7.59	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(N2CCN(CCO)CC2)o1
E3 Binder	CHEMBL3987067	ChEMBL	7.58	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(NC2CNC2)o1
E3 Binder	CHEMBL3898966	ChEMBL	7.6	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc[nH]1
E3 Binder	CHEMBL4648202	ChEMBL	8.37	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCC(F)(F)C(C)(C)O
E3 Binder	CHEMBL4649875	ChEMBL	8.39	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL4648225	ChEMBL	7.62	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCCO
E3 Binder	CHEMBL4636136	ChEMBL	8.24	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1
E3 Binder	CHEMBL4647594	ChEMBL	7.72	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NC[C@@H](C)C(C)(C)O
E3 Binder	CHEMBL4643871	ChEMBL	8.62	—	—	CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4649636	ChEMBL	8.06	—	—	CC(C)Nc1cc(Nc2ccc3nonc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3906505	ChEMBL	8.6	—	—	CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1-c1nnc(C(=O)N2CC[C@@H](O)C2)s1
E3 Binder	CHEMBL4645407	ChEMBL	8.46	—	—	CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4641886	ChEMBL	8.28	—	—	CC(C)Nc1cc(Nc2ccn3nccc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4641090	ChEMBL	8.49	—	—	CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4634922	ChEMBL	8.47	EXF	—	CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3353190	ChEMBL	8.72	—	—	CC(C)Nc1cc(Nc2ncc(C#N)cc2Cl)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3353194	ChEMBL	8.28	—	—	CC(C)Nc1cc(Nc2ncc(C#N)cn2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3353193	ChEMBL	8.46	—	—	CC(C)Nc1cc(Nc2ncc(Cl)cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108971	ChEMBL	6.82	—	—	CC(C)Nc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL5283897	ChEMBL	7.29	—	—	CC(C)Nc1nc(Nc2cnn(C)c2)nc2ccc(CC#N)nc12
E3 Binder	CHEMBL3601070	ChEMBL	7.57	—	—	CC(C)Oc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL4086222	ChEMBL	7.14	8BY	—	CC(C)Oc1cc2c(-c3ccc(C#N)cc3)cccc2cc1C(N)=O
E3 Binder	CHEMBL4092338	ChEMBL	8.34	8CD	—	CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O
E3 Binder	CHEMBL4064661	ChEMBL	6.08	—	—	CC(C)Oc1cc2c(OC[C@H]3CCC(=O)N3)nccc2cc1C(N)=O
E3 Binder	CHEMBL4061493	ChEMBL	6.84	8C1	—	CC(C)Oc1cc2c(O[C@@H]3CCCNC3)ccnc2cc1C(N)=O
E3 Binder	CHEMBL4089619	ChEMBL	6.92	—	—	CC(C)Oc1cc2c(O[C@@H]3CCCNC3)nccc2cc1C(N)=O
E3 Binder	CHEMBL3961117	ChEMBL	6.54	—	—	CC(C)Oc1ccc(Cl)cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL4110934	ChEMBL	6.68	—	—	CC(C)S(=O)(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4107384	ChEMBL	7.89	—	—	CC(C)[C@@H](CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113503	ChEMBL	7.64	—	—	CC(C)[C@H]1C[C@@H](Nc2nc(N3CCC(c4cncnc4)CC3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL4114443	ChEMBL	7.14	—	—	CC(C)[C@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL4110321	ChEMBL	6.07	—	—	CC(C)[C@H]1C[C@@H](Nc2nc[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL4085735	ChEMBL	8.32	—	—	CC(C)c1c[nH]c2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12
E3 Binder	CHEMBL4107677	ChEMBL	8.32	—	—	CC(C)c1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)[nH]n1
E3 Binder	CHEMBL4099061	ChEMBL	7.8	—	—	CC(C)c1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c2c1
E3 Binder	CHEMBL4294631	ChEMBL	7.38	—	—	CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12
E3 Binder	CHEMBL4294023	ChEMBL	7.81	—	—	CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](N4CCOCC4)CC3)c12
E3 Binder	CHEMBL209202	ChEMBL	6.0	—	—	CC(C)n1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21
E3 Binder	CHEMBL4799791	ChEMBL	7.11	—	—	CC(C)n1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL4112222	ChEMBL	8.37	—	—	CC(C)n1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4109253	ChEMBL	8.46	—	—	CC(C)n1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL3601191	ChEMBL	6.81	—	—	CC(C)n1ccc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1=O
E3 Binder	CHEMBL5178313	ChEMBL	8.57	—	—	CC(C)n1ccc2nc(Nc3ccc4cnn(C(C)C)c4c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21
E3 Binder	CHEMBL5205770	ChEMBL	8.3	—	—	CC(C)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL4276955	ChEMBL	7.16	CJN	—	CC(C)n1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c21
E3 Binder	CHEMBL5193503	ChEMBL	8.37	—	—	CC(C)n1ncc2ccc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4c(ccn4C(F)F)n3)cc21
E3 Binder	CHEMBL5200765	ChEMBL	8.39	—	—	CC(C)n1ncc2ccc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4c(ccn4C)n3)cc21
E3 Binder	CHEMBL4107752	ChEMBL	8.8	—	—	CC(CCF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4111866	ChEMBL	8.15	—	—	CC(CCF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110098	ChEMBL	8.74	—	—	CC(CCO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110348	ChEMBL	8.54	—	—	CC(CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109783	ChEMBL	8.72	—	—	CC(CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4115236	ChEMBL	7.8	—	—	CC(CNc1cc(-n2ncc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)N1CCOCC1
E3 Binder	CHEMBL4113184	ChEMBL	8.6	—	—	CC(Cn1cc(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1)OC(F)F
E3 Binder	CHEMBL4107607	ChEMBL	7.93	—	—	CC(F)(CO)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113628	ChEMBL	8.77	—	—	CC(F)(F)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4114244	ChEMBL	8.72	—	—	CC(F)(F)Cn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4109670	ChEMBL	8.21	—	—	CC(F)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109898	ChEMBL	8.59	—	—	CC(F)Cn1cc(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL3946796	ChEMBL	8.7	—	—	CC(F)[C@H](C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3933400	ChEMBL	8.41	—	—	CC(F)[C@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107426	ChEMBL	8.62	—	—	CC(Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C(F)(F)F
E3 Binder	CHEMBL4107224	ChEMBL	8.39	—	—	CC(Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C(F)(F)F
E3 Binder	CHEMBL3889839	ChEMBL	7.12	—	—	CC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)C1
E3 Binder	CHEMBL3890299	ChEMBL	8.3	—	—	CC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3893473	ChEMBL	7.62	—	—	CC(O)CC(C)Oc1cc2ncccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL3916413	ChEMBL	8.28	—	—	CC(O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4115108	ChEMBL	8.64	—	—	CC(O)CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107049	ChEMBL	8.06	—	—	CC(O)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3909778	ChEMBL	7.48	—	—	CC(O)CCOc1cc2ncccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL3983974	ChEMBL	6.11	—	—	CC(O)CNc1nc(N2CCOCC2)[nH]c(=O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114259	ChEMBL	6.84	—	—	CC1(C)CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL4456286	ChEMBL	8.21	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(C#N)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4462969	ChEMBL	7.51	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(C(F)F)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4520118	ChEMBL	8.96	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(C(N)=O)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4550566	ChEMBL	7.46	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(C5CC5)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4518559	ChEMBL	8.19	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(CO)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4466092	ChEMBL	8.49	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(O)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4474664	ChEMBL	7.47	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cc(OC(F)F)cnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4461516	ChEMBL	8.49	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(C(N)=O)CC3)cc2O1
E3 Binder	CHEMBL4452936	ChEMBL	8.0	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(C(O)C(F)(F)F)CC3)cc2O1
E3 Binder	CHEMBL4467170	ChEMBL	8.82	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(CO)CC3)cc2O1
E3 Binder	CHEMBL4531013	ChEMBL	8.24	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCCC(O)CC3)cc2O1
E3 Binder	CHEMBL4459509	ChEMBL	7.92	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCCC3)cc2O1
E3 Binder	CHEMBL4483551	ChEMBL	8.68	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CC(N)=O)CC3)cc2O1
E3 Binder	CHEMBL4584820	ChEMBL	8.18	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CCO)CC3)cc2O1
E3 Binder	CHEMBL4569547	ChEMBL	7.89	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCNCC3)cc2O1
E3 Binder	CHEMBL4557715	ChEMBL	7.52	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL4439292	ChEMBL	8.21	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1O
E3 Binder	CHEMBL4473269	ChEMBL	8.44	LS7	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4444608	ChEMBL	7.85	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2S1(=O)=O
E3 Binder	CHEMBL4464216	ChEMBL	7.66	—	—	CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2[S+]1[O-]
E3 Binder	CHEMBL4780798	ChEMBL	6.89	—	—	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C56CCN(CC5)CC6)no4)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4784181	ChEMBL	6.24	—	—	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C5CC5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4758887	ChEMBL	6.44	—	—	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C56CCN(CC5)CC6)o4)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4784784	ChEMBL	6.85	—	—	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C5CC5)o4)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4748154	ChEMBL	7.23	W9D	—	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4776227	ChEMBL	6.8	—	—	CC1(C)OC(=O)c2ccc(Nc3ncc(C(N)=O)c(N[C@H](CO)c4ccccc4)n3)cc21
E3 Binder	CHEMBL4109689	ChEMBL	8.24	—	—	CC1(CNc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)COC1
E3 Binder	CHEMBL2105728	ChEMBL	6.11	6T2	—	CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1
E3 Binder	CHEMBL4114460	ChEMBL	8.92	—	—	CC1(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1
E3 Binder	CHEMBL4113284	ChEMBL	8.46	—	—	CC1(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1
E3 Binder	CHEMBL4111088	ChEMBL	8.57	—	—	CC1(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1
E3 Binder	CHEMBL3940600	ChEMBL	6.89	—	—	CC1(Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)CCCNC1
E3 Binder	CHEMBL3960645	ChEMBL	6.82	—	—	CC1(Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CCCNC1
E3 Binder	CHEMBL4109668	ChEMBL	7.51	—	—	CC1(O)CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4112264	ChEMBL	6.24	—	—	CC1CC(C)CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)C1
E3 Binder	CHEMBL3979957	ChEMBL	7.04	—	—	CC1CCC(Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)CN1
E3 Binder	CHEMBL4111300	ChEMBL	6.55	—	—	CC1CCCCN1c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4108005	ChEMBL	6.85	—	—	CC1CCCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4109926	ChEMBL	7.16	—	—	CC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4115548	ChEMBL	6.52	—	—	CC1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC(C)O1
E3 Binder	CHEMBL4112492	ChEMBL	7.01	—	—	CC1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL4114135	ChEMBL	7.97	—	—	CC1COCCN1CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3900478	ChEMBL	6.48	—	—	CCC(CO)Nc1nc(N2CCOCC2)[nH]c(=O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115569	ChEMBL	8.03	—	—	CCC(O)(CC)[C@H](F)CNC(=O)c1cnc(-n2ncc3cncnc32)cc1NC(C)C
E3 Binder	CHEMBL4777409	ChEMBL	8.19	—	—	CCC1(O)CCCN(c2nc3nc(N4CCOCC4)oc3cc2NC(=O)c2coc(-c3ccnc(C)c3)n2)C1
E3 Binder	CHEMBL4112394	ChEMBL	8.49	—	—	CCCC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4108657	ChEMBL	8.07	—	—	CCCCNC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3951721	ChEMBL	8.28	—	—	CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1COC1
E3 Binder	CHEMBL3930830	ChEMBL	8.2	—	—	CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3979646	ChEMBL	8.11	—	—	CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1
E3 Binder	CHEMBL3894173	ChEMBL	8.19	—	—	CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H](C)CO
E3 Binder	CHEMBL4632511	ChEMBL	8.15	—	—	CCCCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C
E3 Binder	CHEMBL5280941	ChEMBL	7.6	—	—	CCCCn1cc(NC(=O)c2coc(-c3ccnc(C)c3)n2)c(C(N)=O)n1.Cl
E3 Binder	CHEMBL3892984	ChEMBL	6.36	—	—	CCCN(C)c1ncc2scc(C(=O)Nc3cc(Cl)ccc3OC)c2n1
E3 Binder	CHEMBL4111603	ChEMBL	8.23	—	—	CCCNC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3970139	ChEMBL	7.94	—	—	CCCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C
E3 Binder	CHEMBL3971510	ChEMBL	8.4	—	—	CCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4749598	ChEMBL	6.77	—	—	CCCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL4644871	ChEMBL	7.92	—	—	CCCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C
E3 Binder	CHEMBL4108677	ChEMBL	8.68	—	—	CCCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107116	ChEMBL	8.59	—	—	CCCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4112023	ChEMBL	8.55	—	—	CCCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL2018068	ChEMBL	6.62	—	—	CCCNc1nc(C)c(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL4113892	ChEMBL	8.55	—	—	CCCOC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4103497	ChEMBL	8.89	—	—	CCC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12
E3 Binder	CHEMBL4111230	ChEMBL	8.85	—	—	CCCn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4107733	ChEMBL	8.6	—	—	CCCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4113237	ChEMBL	8.54	—	—	CCCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4109113	ChEMBL	8.6	—	—	CCCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4107826	ChEMBL	7.88	—	—	CCN(CC)C(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL535	ChEMBL	7.18	B49	—	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C
E3 Binder	CHEMBL4782731	ChEMBL	7.78	—	—	CCN(CC)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL1232515	ChEMBL	8.1	EML	—	CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO
E3 Binder	CHEMBL1650533	ChEMBL	8.1	—	—	CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO.Cl
E3 Binder	CHEMBL3919803	ChEMBL	7.91	—	—	CCNC(=O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3889742	ChEMBL	8.77	—	—	CCNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3920482	ChEMBL	8.46	—	—	CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL4745378	ChEMBL	6.72	—	—	CCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL4639599	ChEMBL	7.82	—	—	CCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C
E3 Binder	CHEMBL4114115	ChEMBL	8.82	—	—	CCNC(=O)n1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL5087642	ChEMBL	8.8	—	—	CCNc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2c1[nH]c1cc(C#N)ccc12
E3 Binder	CHEMBL4115161	ChEMBL	8.85	—	—	CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3921034	ChEMBL	8.6	—	—	CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL4110658	ChEMBL	8.35	—	—	CCNc1cc(-n2ccc3cc(C(N)=O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107964	ChEMBL	8.15	—	—	CCNc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110619	ChEMBL	8.49	—	—	CCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109995	ChEMBL	8.19	—	—	CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108507	ChEMBL	7.97	—	—	CCNc1cc(-n2ncc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4109340	ChEMBL	6.75	—	—	CCOC(=O)C1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL208709	ChEMBL	6.0	—	—	CCOC(=O)CCn1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21
E3 Binder	CHEMBL210194	ChEMBL	6.4	—	—	CCOC(=O)Cn1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21
E3 Binder	CHEMBL4106902	ChEMBL	8.17	—	—	CCOC(=O)N1CC(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL4115180	ChEMBL	8.27	—	—	CCOC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4748045	ChEMBL	6.47	—	—	CCOC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL3901125	ChEMBL	6.02	—	—	CCOC(=O)c1nc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)sc1C
E3 Binder	CHEMBL4115629	ChEMBL	8.62	—	—	CCOC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4108910	ChEMBL	8.43	—	—	CCOC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3910846	ChEMBL	8.15	—	—	CCOCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1
E3 Binder	CHEMBL3965756	ChEMBL	7.8	—	—	CCOP(=O)(CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C)OCC
E3 Binder	CHEMBL4750612	ChEMBL	6.7	—	—	CCOc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(CCC(C)(C)O)nc12
E3 Binder	CHEMBL4073250	ChEMBL	7.62	—	—	CCOc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O
E3 Binder	CHEMBL4750066	ChEMBL	7.15	—	—	CCOc1cc2nc(CCC(C)(C)C(=O)OC)n(C)c2cc1NC(=O)c1cccc(C(F)(F)F)n1
E3 Binder	CHEMBL4779374	ChEMBL	7.24	—	—	CCS(=O)(=O)N1CC(n2cc3cc(NC(=O)c4cccc(C(F)(F)F)n4)c(C(C)(C)O)cc3n2)C1
E3 Binder	CHEMBL3934549	ChEMBL	8.23	—	—	CCS(=O)(=O)N1CCC(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL4115626	ChEMBL	6.26	—	—	CCS(=O)(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4746200	ChEMBL	6.89	—	—	CCS(=O)(=O)NCCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL4112913	ChEMBL	8.8	—	—	CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107281	ChEMBL	8.47	—	—	CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL4114010	ChEMBL	8.55	—	—	CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3910622	ChEMBL	8.36	—	—	CC[C@@H](CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3896654	ChEMBL	8.39	—	—	CC[C@@H](CO)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4112464	ChEMBL	8.03	—	—	CC[C@@H](F)CNc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4091434	ChEMBL	9.3	—	—	CC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12
E3 Binder	CHEMBL4520946	ChEMBL	9.7	—	—	CC[C@@H]1[C@H](F)C(=O)N[C@@H]1COc1cccc2cc(C(N)=O)c(OC)cc12
E3 Binder	CHEMBL3967712	ChEMBL	8.33	—	—	CC[C@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3895603	ChEMBL	8.72	—	—	CC[C@H](C)Nc1cc(-n2ncc3cc(Cl)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4066705	ChEMBL	10.0	—	—	CC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@@H]1F
E3 Binder	CHEMBL4077215	ChEMBL	7.89	—	—	CCc1c[nH]c2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12
E3 Binder	CHEMBL5271317	ChEMBL	7.85	—	—	CCc1cc(-c2nc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)co2)ccn1
E3 Binder	CHEMBL4793633	ChEMBL	7.42	—	—	CCc1cc(Nc2ncc(C(=O)NC)c(N[C@H](CO)c3ccccc3)n2)ccc1C#N
E3 Binder	CHEMBL3735401	ChEMBL	6.33	—	—	CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O
E3 Binder	CHEMBL3746678	ChEMBL	6.63	—	—	CCc1cc2c(cc1-c1cnn(CCCN(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O
E3 Binder	CHEMBL2441273	ChEMBL	8.4	—	—	CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1
E3 Binder	CHEMBL4072093	ChEMBL	7.77	—	—	CCc1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c2c1
E3 Binder	CHEMBL3622185	ChEMBL	6.01	—	—	CCc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4436128	ChEMBL	7.02	—	—	CCn1c(N2CCOCC2)nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc21
E3 Binder	CHEMBL5266861	ChEMBL	9.0	—	—	CCn1cc(NC(=O)c2ccc3cnc(NC4CCCCC4N)nn23)c(C(N)=O)n1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL4781999	ChEMBL	7.49	—	—	CCn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL5275145	ChEMBL	7.8	—	—	CCn1cc(NC(=O)c2coc(-c3ccnc(C)c3)n2)c(C(N)=O)n1.Cl
E3 Binder	CHEMBL5278052	ChEMBL	7.7	—	—	CCn1cc(NC(=O)c2csc(-c3ccncc3)n2)c(C(N)=O)n1.Cl
E3 Binder	CHEMBL4106801	ChEMBL	8.92	—	—	CCn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4109693	ChEMBL	8.54	—	—	CCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4106715	ChEMBL	8.62	—	—	CCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4110545	ChEMBL	8.77	—	—	CCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4112477	ChEMBL	8.39	—	—	CCn1nnnc1-c1ccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1
E3 Binder	CHEMBL4086115	ChEMBL	8.05	—	—	CN(C)C(=O)C1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL5201376	ChEMBL	9.1	—	—	CN(C)C(=O)CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL4104802	ChEMBL	8.52	—	—	CN(C)C(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL256733	ChEMBL	7.31	—	—	CN(C)C(=O)c1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
E3 Binder	CHEMBL1908395	ChEMBL	6.07	—	—	CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1.Cl
E3 Binder	CHEMBL5200432	ChEMBL	9.0	—	—	CN(C)CC(=O)N1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL3969222	ChEMBL	7.28	—	—	CN(C)CC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1
E3 Binder	CHEMBL4466563	ChEMBL	6.27	—	—	CN(C)CCCNC(=O)c1nn(C)cc1NC(=O)c1cccc(-c2ccnc(NCC3CC3)c2)n1
E3 Binder	CHEMBL4064106	ChEMBL	7.3	—	—	CN(C)CCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4791626	ChEMBL	9.26	—	—	CN(C)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL4754306	ChEMBL	7.46	—	—	CN(C)CCn1cc2cc(NC(=O)c3nc(C(F)(F)F)cs3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL4110138	ChEMBL	7.21	—	—	CN(C)[C@@H]1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4111716	ChEMBL	6.8	—	—	CN(C)[C@H]1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4069890	ChEMBL	6.72	—	—	CN(C)[C@H]1CC[C@H](N(C)c2ncnc3[nH]cc(C4CCOCC4)c23)CC1
E3 Binder	CHEMBL3353186	ChEMBL	7.0	—	—	CN(C)[C@H]1CC[C@H](Nc2nc(Nc3ccccc3)nc3[nH]ccc23)CC1
E3 Binder	CHEMBL4087705	ChEMBL	6.39	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]c4c(c23)CCC4)CC1
E3 Binder	CHEMBL3353184	ChEMBL	7.0	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C#N)c23)CC1
E3 Binder	CHEMBL4064168	ChEMBL	6.85	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C(C)(C)C)c23)CC1
E3 Binder	CHEMBL4063127	ChEMBL	7.0	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C(F)(F)F)c23)CC1
E3 Binder	CHEMBL4091013	ChEMBL	7.96	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CC4)c23)CC1
E3 Binder	CHEMBL4078625	ChEMBL	8.52	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCC4)c23)CC1
E3 Binder	CHEMBL4097418	ChEMBL	8.22	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCCC4)c23)CC1
E3 Binder	CHEMBL4075333	ChEMBL	6.57	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCCO4)c23)CC1
E3 Binder	CHEMBL4061227	ChEMBL	7.8	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCCOC4)c23)CC1
E3 Binder	CHEMBL4081502	ChEMBL	8.1	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCOC4)c23)CC1
E3 Binder	CHEMBL4089379	ChEMBL	8.22	6QY	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCOCC4)c23)CC1
E3 Binder	CHEMBL3353185	ChEMBL	7.0	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(F)c23)CC1
E3 Binder	CHEMBL4292700	ChEMBL	6.45	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc([C@H]4CC[C@@H](C(N)=O)CC4)c23)CC1
E3 Binder	CHEMBL4279192	ChEMBL	8.4	CJT	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc([C@H]4CC[C@H](C(N)=O)CC4)c23)CC1
E3 Binder	CHEMBL4093475	ChEMBL	6.2	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]ccc23)CC1
E3 Binder	CHEMBL4090409	ChEMBL	6.52	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3cc(F)c(F)cc23)CC1
E3 Binder	CHEMBL4068395	ChEMBL	8.0	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(Br)cc23)CC1
E3 Binder	CHEMBL4083650	ChEMBL	8.15	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(C#N)cc23)CC1
E3 Binder	CHEMBL4101649	ChEMBL	8.05	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)CC1
E3 Binder	CHEMBL4063472	ChEMBL	7.92	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(C4CC4)cc23)CC1
E3 Binder	CHEMBL4288880	ChEMBL	6.35	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccn(C4CCOCC4)c23)CC1
E3 Binder	CHEMBL4287208	ChEMBL	6.22	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3ccsc23)CC1
E3 Binder	CHEMBL4294035	ChEMBL	6.09	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3cscc23)CC1
E3 Binder	CHEMBL3361252	ChEMBL	7.3	6QX	—	CN(C)[C@H]1CC[C@H](Nc2ncnc3sc4c(c23)CCC4)CC1
E3 Binder	CHEMBL4282412	ChEMBL	7.01	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnn3ccc(C4CCOCC4)c23)CC1
E3 Binder	CHEMBL4285338	ChEMBL	7.35	—	—	CN(C)[C@H]1CC[C@H](Nc2ncnn3ccc([C@H]4CC[C@H](C(N)=O)CC4)c23)CC1
E3 Binder	CHEMBL4097089	ChEMBL	7.36	—	—	CN(C)[C@H]1CC[C@H](Oc2ncnc3[nH]cc(C4CCOCC4)c23)CC1
E3 Binder	CHEMBL4079234	ChEMBL	7.24	76P	—	CN(C)[C@H]1CC[C@H](Oc2ncnc3ccc([N+](=O)[O-])cc23)CC1
E3 Binder	CHEMBL4283453	ChEMBL	6.17	—	—	CN(C)[C@H]1CC[C@H](Oc2ncnn3ccc([C@H]4CC[C@H](C(N)=O)CC4)c23)CC1
E3 Binder	CHEMBL4518357	ChEMBL	6.72	—	—	CN(C)[C@H]1CN(C(=O)c2nn(C)cc2NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)C[C@@H]1O
E3 Binder	CHEMBL3971885	ChEMBL	6.13	—	—	CN(C)c1ccc(Cl)cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3601072	ChEMBL	8.4	—	—	CN(C)c1ccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
E3 Binder	CHEMBL4551768	ChEMBL	7.58	—	—	CN(C)c1ccc2cc(NC(=O)c3cnn4cccnc34)c(N3CCCCC3)cc2n1
E3 Binder	CHEMBL3601076	ChEMBL	7.92	—	—	CN(C)c1cccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
E3 Binder	CHEMBL4110426	ChEMBL	7.13	—	—	CN(C)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL3622511	ChEMBL	6.31	—	—	CN(C)c1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4464832	ChEMBL	9.3	—	—	CN(C)c1nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc2s1
E3 Binder	CHEMBL4106632	ChEMBL	6.72	—	—	CN(CCO)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4111977	ChEMBL	6.51	—	—	CN(Cc1ccccc1)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4115266	ChEMBL	7.71	—	—	CN(N)/C=C(\N)C1CCN(c2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3892709	ChEMBL	6.41	—	—	CN(c1nc(NC2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1)[C@H]1CC[C@H](O)CC1
E3 Binder	CHEMBL4113079	ChEMBL	6.6	—	—	CN(c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1)[C@H](CO)c1ccccc1
E3 Binder	CHEMBL482708	ChEMBL	6.4	JNF	—	CN(c1nccc(-c2cnc3ccccn23)n1)C1CCCCC1
E3 Binder	CHEMBL485324	ChEMBL	6.7	—	—	CN(c1nccc(-c2cnc3ccccn23)n1)C1CCNCC1
E3 Binder	CHEMBL4078222	ChEMBL	8.7	6QZ	—	CN1C(=O)C[C@@H]2CN([C@H]3CC[C@H](Nc4ncnc5[nH]cc(C6CCOCC6)c45)CC3)CC[C@@H]21
E3 Binder	CHEMBL4102501	ChEMBL	8.7	6R0	—	CN1C(=O)C[C@H]2CN([C@H]3CC[C@H](Nc4ncnc5[nH]cc(C6CCOCC6)c45)CC3)CC[C@H]21
E3 Binder	CHEMBL5178970	ChEMBL	8.7	—	—	CN1CC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CCC1=O
E3 Binder	CHEMBL4782761	ChEMBL	6.75	—	—	CN1CC(n2cc3cc(NC(=O)c4cccc(C(F)(F)F)n4)c(C(C)(C)O)cc3n2)C1
E3 Binder	CHEMBL5195464	ChEMBL	7.82	—	—	CN1CC2(CC(n3cc(Nc4nc(NC5(C)CC5)c5c(=O)n(-c6cn(C)nn6)ccc5n4)cn3)C2)C1
E3 Binder	CHEMBL5193024	ChEMBL	9.0	—	—	CN1CC2(CC(n3cc(Nc4nc(NC5(C)CC5)c5c(=O)n(C)ccc5n4)cn3)C2)C1
E3 Binder	CHEMBL5178692	ChEMBL	8.4	—	—	CN1CC2(CC(n3cc(Nc4nc(NC5(C)CC5)c5c(=O)n(CC(F)F)ccc5n4)cn3)C2)C1
E3 Binder	CHEMBL5285779	ChEMBL	8.52	—	—	CN1CC2(CC(n3cc(Nc4nc(OC5(C)CC5)c5nc(C6CC6)c(F)cc5n4)cn3)C2)C1
E3 Binder	CHEMBL4472816	ChEMBL	6.14	—	—	CN1CCC(CNC(=O)c2nn(C)cc2NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)C1
E3 Binder	CHEMBL4109087	ChEMBL	6.16	—	—	CN1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4741772	ChEMBL	6.77	—	—	CN1CCC(c2nnc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)o2)CC1
E3 Binder	CHEMBL4778959	ChEMBL	6.66	—	—	CN1CCC(c2noc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)n2)CC1
E3 Binder	CHEMBL5190559	ChEMBL	8.22	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cn(C)nn5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5191035	ChEMBL	8.4	B7R	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cncnc5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5193053	ChEMBL	9.0	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cnn[nH]5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5207748	ChEMBL	7.96	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5nnc[nH]5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5189582	ChEMBL	8.52	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C(F)F)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5174529	ChEMBL	9.0	B6I	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5193495	ChEMBL	8.4	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C5CC5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5186874	ChEMBL	8.7	—	—	CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(CC(F)F)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5288696	ChEMBL	9.0	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cccnc5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5283237	ChEMBL	6.31	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5ccn(C)n5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5281595	ChEMBL	9.0	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5ccnnc5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5270577	ChEMBL	6.14	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cn(C)cn5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5269297	ChEMBL	7.72	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cn(C)nn5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5290090	ChEMBL	9.0	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)c(F)cc4n3)cn2)CC1
E3 Binder	CHEMBL5283628	ChEMBL	9.22	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5266181	ChEMBL	8.52	ND2	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cnn(C)c5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5275280	ChEMBL	7.89	NBW	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(C(=O)N(C)C)ccc4n3)cn2)CC1
E3 Binder	CHEMBL5281524	ChEMBL	8.7	—	—	CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(C5CC5)ccc4n3)cn2)CC1
E3 Binder	CHEMBL4524886	ChEMBL	8.13	—	—	CN1CCC2(CC1)Cc1cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc1O2
E3 Binder	CHEMBL4110996	ChEMBL	7.62	—	—	CN1CCC2(CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)C2)C1
E3 Binder	CHEMBL4110192	ChEMBL	8.06	—	—	CN1CCC2(CCN(c3nc(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)C1=O
E3 Binder	CHEMBL4106466	ChEMBL	6.07	—	—	CN1CCC2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4ccc5ccccc5n4)c(=O)[nH]3)C2C1
E3 Binder	CHEMBL4466893	ChEMBL	6.58	—	—	CN1CCCC(CNC(=O)c2nn(C)cc2NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)C1
E3 Binder	CHEMBL3982323	ChEMBL	6.14	—	—	CN1CCCC(Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)C1
E3 Binder	CHEMBL3622521	ChEMBL	6.45	—	—	CN1CCC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)C1
E3 Binder	CHEMBL5087788	ChEMBL	8.3	—	—	CN1CCN(C(=O)c2cccc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2)CC1
E3 Binder	CHEMBL4087971	ChEMBL	7.77	—	—	CN1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL5185436	ChEMBL	7.92	—	—	CN1CCN(c2cc(F)cc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4sccc4n3)c2)CC1
E3 Binder	CHEMBL5085200	ChEMBL	7.75	—	—	CN1CCN(c2cc(F)cc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2)CC1
E3 Binder	CHEMBL5180689	ChEMBL	7.3	—	—	CN1CCN(c2cc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4sccc4n3)ccc2F)CC1
E3 Binder	CHEMBL5188095	ChEMBL	8.15	—	—	CN1CCN(c2cc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4sccc4n3)ccn2)CC1
E3 Binder	CHEMBL5091192	ChEMBL	8.22	—	—	CN1CCN(c2cc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)ccn2)CC1
E3 Binder	CHEMBL3909110	ChEMBL	6.29	—	—	CN1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL254546	ChEMBL	6.16	—	—	CN1CCN(c2ccc(NC(=O)c3csc(-c4cccnc4)n3)cc2)CC1
E3 Binder	CHEMBL5080176	ChEMBL	7.58	—	—	CN1CCN(c2ccc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)cn2)CC1
E3 Binder	CHEMBL522892	ChEMBL	6.89	38O	—	CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1
E3 Binder	CHEMBL3353200	ChEMBL	8.59	—	—	CN1CCN(c2cccc(Nc3ncc(-c4nc5ccccc5s4)c(NC4C[C@H](CO)[C@@H](O)[C@H]4O)n3)c2)CC1.Cl
E3 Binder	CHEMBL3964751	ChEMBL	7.01	—	—	CN1CCN(c2nc(NC3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4107356	ChEMBL	7.52	—	—	CN1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4c(C5CC5)nccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3622517	ChEMBL	7.37	—	—	CN1CCN(c2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL5209502	ChEMBL	9.0	—	—	CN1CC[C@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)[C@@H](F)C1
E3 Binder	CHEMBL5193253	ChEMBL	9.22	—	—	CN1CC[C@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)[C@H](F)C1
E3 Binder	CHEMBL4592237	ChEMBL	7.1	—	—	CN1CCc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL5187604	ChEMBL	8.52	—	—	CN1C[C@@H]2C[C@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1
E3 Binder	CHEMBL5171632	ChEMBL	7.8	—	—	CN1C[C@H]2C[C@@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1
E3 Binder	CHEMBL5184407	ChEMBL	8.4	—	—	CN1C[C@H]2C[C@@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(CC(F)F)ccc3n2)cn1
E3 Binder	CHEMBL4468790	ChEMBL	9.42	—	—	CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL4537890	ChEMBL	8.14	—	—	CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2S1(=O)=O
E3 Binder	CHEMBL255253	ChEMBL	6.04	—	—	CN1[C@@H]2CC[C@H]1CC(Nc1cccc(-c3cnc4ccccn34)n1)C2
E3 Binder	CHEMBL4114042	ChEMBL	6.96	—	—	CNC(=O)C1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL4438027	ChEMBL	8.46	—	—	CNC(=O)CN1CCN(c2cc3c(cc2NC(=O)c2cnn4cccnc24)CC(C)(C)O3)CC1
E3 Binder	CHEMBL4290202	ChEMBL	6.68	—	—	CNC(=O)C[C@@H](C)c1ccn2ncnc(N[C@H]3CC[C@H](N4CCN(C(=O)OC)CC4)CC3)c12
E3 Binder	CHEMBL3910861	ChEMBL	7.71	—	—	CNC(=O)C[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL4109570	ChEMBL	6.7	—	—	CNC(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4115518	ChEMBL	8.33	—	—	CNC(=O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1
E3 Binder	CHEMBL4110155	ChEMBL	8.02	—	—	CNC(=O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3920819	ChEMBL	7.94	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)ccc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3917746	ChEMBL	8.08	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2CCC(C)(C)O)CC1
E3 Binder	CHEMBL3902828	ChEMBL	8.96	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3986991	ChEMBL	7.88	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3954007	ChEMBL	8.15	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL3938824	ChEMBL	8.48	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2N[C@@H](C)CO)CC1
E3 Binder	CHEMBL3973778	ChEMBL	7.85	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3911840	ChEMBL	8.36	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL4112444	ChEMBL	8.48	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2N[C@@H]2CCCC[C@H]2F)CC1
E3 Binder	CHEMBL3919786	ChEMBL	8.66	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2N[C@H]2CCCC[C@@H]2F)CC1
E3 Binder	CHEMBL3900682	ChEMBL	8.77	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3894635	ChEMBL	8.08	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3953153	ChEMBL	7.8	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2N[C@@H](C)CF)CC1
E3 Binder	CHEMBL3914366	ChEMBL	8.25	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(Cl)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3353195	ChEMBL	8.82	—	—	CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(Nc3ccc4ncsc4n3)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL3935695	ChEMBL	8.49	—	—	CNC(=O)c1ccc(Nc2cc(Nc3ccc4ncsc4c3)ncc2-c2nnc(C(=O)N3CC[C@@H](O)C3)s2)cc1
E3 Binder	CHEMBL4107577	ChEMBL	8.44	—	—	CNC(=O)c1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1
E3 Binder	CHEMBL3961524	ChEMBL	8.04	—	—	CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C
E3 Binder	CHEMBL4059465	ChEMBL	8.3	—	—	CNC(=O)c1cnc(Nc2ccc(C#N)cc2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4087806	ChEMBL	8.0	—	—	CNC(=O)c1cnc(Nc2ccc(F)cc2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4095514	ChEMBL	7.89	—	—	CNC(=O)c1cnc(Nc2ccc(OC)c(F)c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4068127	ChEMBL	8.0	—	—	CNC(=O)c1cnc(Nc2ccc(OC)cc2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4101382	ChEMBL	8.4	—	—	CNC(=O)c1cnc(Nc2ccc3[nH]ncc3c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4761884	ChEMBL	7.33	—	—	CNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL4065667	ChEMBL	8.3	—	—	CNC(=O)c1cnc(Nc2ccc3c(c2)CC(=O)N3)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4075758	ChEMBL	8.0	—	—	CNC(=O)c1cnc(Nc2ccc3c(c2)CC(=O)N3C)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4077863	ChEMBL	7.89	—	—	CNC(=O)c1cnc(Nc2ccc3c(cnn3C)c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4068348	ChEMBL	6.14	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC
E3 Binder	CHEMBL4633251	ChEMBL	7.68	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C
E3 Binder	CHEMBL4081634	ChEMBL	7.89	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CCCC1
E3 Binder	CHEMBL4059689	ChEMBL	7.7	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CCCCC1
E3 Binder	CHEMBL4075948	ChEMBL	6.77	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NCCO
E3 Binder	CHEMBL4075955	ChEMBL	8.33	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4071076	ChEMBL	7.33	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@@H]1CCCC[C@H]1O
E3 Binder	CHEMBL4093910	ChEMBL	7.3	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)CC(C)C
E3 Binder	CHEMBL4079743	ChEMBL	8.0	9YS	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4793479	ChEMBL	7.72	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL4069224	ChEMBL	7.09	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CCCC[C@@H]1O
E3 Binder	CHEMBL4098137	ChEMBL	6.89	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CCCC[C@H]1O
E3 Binder	CHEMBL4094792	ChEMBL	7.96	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CCC[C@@H](O)C1
E3 Binder	CHEMBL4078264	ChEMBL	7.6	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CCC[C@H](O)C1
E3 Binder	CHEMBL4067341	ChEMBL	7.68	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CC[C@H](NC(C)=O)CC1
E3 Binder	CHEMBL4102532	ChEMBL	7.4	—	—	CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]1CC[C@H](O)CC1
E3 Binder	CHEMBL3353197	ChEMBL	8.74	—	—	CNC(=O)c1nc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)sc1C
E3 Binder	CHEMBL5266171	ChEMBL	8.52	—	—	CNC(=O)c1nn(C)cc1NC(=O)c1ccc2cnc(NCCN)nn12.O=C(O)C(F)(F)F
E3 Binder	CHEMBL3960714	ChEMBL	7.83	—	—	CNS(=O)(=O)N1CCC(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL574737	ChEMBL	6.05	—	—	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O
E3 Binder	CHEMBL3980058	ChEMBL	7.99	—	—	COC(=O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4114846	ChEMBL	8.72	—	—	COC(=O)N1CC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL4109155	ChEMBL	8.14	—	—	COC(=O)N1CC(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL4106530	ChEMBL	6.57	—	—	COC(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4439748	ChEMBL	9.0	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL4556866	ChEMBL	8.3	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)nc34)CC2)CC1
E3 Binder	CHEMBL4438228	ChEMBL	7.16	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C(C)(C)C#N)nc34)CC2)CC1
E3 Binder	CHEMBL4548760	ChEMBL	8.22	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C(C)C#N)nc34)CC2)CC1
E3 Binder	CHEMBL4521212	ChEMBL	8.3	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C)nc34)CC2)CC1
E3 Binder	CHEMBL4581832	ChEMBL	7.77	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C5(C#N)CC5)nc34)CC2)CC1
E3 Binder	CHEMBL4582624	ChEMBL	8.52	K1E	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1
E3 Binder	CHEMBL5173450	ChEMBL	8.3	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccn(C)c(=O)c34)CC2)CC1
E3 Binder	CHEMBL5184305	ChEMBL	7.64	B8I	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccn(CC#N)c(=O)c34)CC2)CC1
E3 Binder	CHEMBL4067181	ChEMBL	8.52	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL4455718	ChEMBL	7.43	K1H	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL4471452	ChEMBL	7.42	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C)cc34)CC2)CC1
E3 Binder	CHEMBL4583622	ChEMBL	6.55	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C)nc34)CC2)CC1
E3 Binder	CHEMBL4288305	ChEMBL	7.48	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1
E3 Binder	CHEMBL4280559	ChEMBL	7.71	—	—	COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc([C@H](C)CC(N)=O)c34)CC2)CC1
E3 Binder	CHEMBL4110862	ChEMBL	8.92	—	—	COC(=O)N1CC[C@@H](Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1
E3 Binder	CHEMBL3932139	ChEMBL	8.31	—	—	COC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL281948	ChEMBL	8.05	KSA	—	COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
E3 Binder	CHEMBL502835	ChEMBL	6.09	XIN	—	COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1
E3 Binder	CHEMBL4466981	ChEMBL	9.49	—	—	COC(C)(C)CCN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
E3 Binder	CHEMBL4107330	ChEMBL	7.71	—	—	COC(C)(C)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108325	ChEMBL	8.82	—	—	COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4109207	ChEMBL	8.8	—	—	COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(CO)C1
E3 Binder	CHEMBL4114108	ChEMBL	8.51	—	—	COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C
E3 Binder	CHEMBL4110810	ChEMBL	8.55	—	—	COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL4114571	ChEMBL	7.66	—	—	COC1(C)CN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL3954925	ChEMBL	8.47	—	—	COC1CCC(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3923198	ChEMBL	8.46	—	—	COC1CCC(O)(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3931480	ChEMBL	8.17	—	—	COC1CCN(c2ccc(NC(=O)c3cnc(-n4ncc5cc(C#N)cnc54)cc3NC(C)C)cn2)CC1
E3 Binder	CHEMBL3913330	ChEMBL	8.0	—	—	COC1CCN(c2ccc(NC(=O)c3cnc(-n4ncc5cc(C#N)cnc54)cc3NC(C)C)nc2)CC1
E3 Binder	CHEMBL4115098	ChEMBL	7.58	—	—	COC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4113386	ChEMBL	7.2	—	—	COC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4108230	ChEMBL	7.4	—	—	COC1CN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C[C@@H]1O
E3 Binder	CHEMBL4108111	ChEMBL	7.09	—	—	COCC1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL4113907	ChEMBL	7.22	—	—	COCCCNc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL4091863	ChEMBL	7.19	—	—	COCCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4530226	ChEMBL	6.73	—	—	COCCNc1cc(-c2cccc(C(=O)Nc3cn(C)nc3C(N)=O)n2)ccn1
E3 Binder	CHEMBL210354	ChEMBL	6.0	—	—	COCCn1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21
E3 Binder	CHEMBL5277206	ChEMBL	7.75	—	—	COCCn1cc(NC(=O)c2coc(-c3ccnc(C)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4107168	ChEMBL	8.1	—	—	COCCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4113624	ChEMBL	8.49	—	—	COCCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4107529	ChEMBL	8.59	—	—	COCCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4079243	ChEMBL	7.92	—	—	COC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12
E3 Binder	CHEMBL4108617	ChEMBL	8.55	—	—	COC[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C
E3 Binder	CHEMBL3590476	ChEMBL	8.22	—	—	COCc1nn(C)cc1NC(=O)c1cnn2ccc(N[C@@H]3CCCC[C@@H]3N)nc12
E3 Binder	CHEMBL3897707	ChEMBL	8.05	—	—	CO[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)ccc32)cc1NC(C)C
E3 Binder	CHEMBL4114417	ChEMBL	7.46	—	—	CO[C@H]1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL3973967	ChEMBL	7.87	—	—	CO[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC2COC2)CC1
E3 Binder	CHEMBL3586487	ChEMBL	6.41	—	—	COc1cc(-c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C)cc3)n2)ccn1
E3 Binder	CHEMBL4763990	ChEMBL	8.35	—	—	COc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)co2)ccn1
E3 Binder	CHEMBL3896014	ChEMBL	6.19	—	—	COc1cc(C(=O)NCCCO)ccc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3960060	ChEMBL	6.08	—	—	COc1cc(C(=O)NCCCO)ccc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL3935363	ChEMBL	6.34	—	—	COc1cc(C(=O)Nc2ccccc2)ccc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL5083561	ChEMBL	6.5	—	—	COc1cc(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1
E3 Binder	CHEMBL256717	ChEMBL	6.38	—	—	COc1cc(N2CCN(C)CC2)ccc1NC(=O)c1cccc(-c2cnn(C)c2)n1
E3 Binder	CHEMBL257127	ChEMBL	6.46	—	—	COc1cc(N2CCN(C)CC2)ccc1NC(=O)c1csc(-c2cccnc2)n1
E3 Binder	CHEMBL5075213	ChEMBL	6.43	—	—	COc1cc(N2CCN(CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2cc[nH]n2)n1
E3 Binder	CHEMBL256713	ChEMBL	7.77	DL1	—	COc1cc(N2CCOCC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1
E3 Binder	CHEMBL403662	ChEMBL	6.8	—	—	COc1cc(N2CCOCC2)ccc1NC(=O)c1csc(-c2cccnc2)n1
E3 Binder	CHEMBL1835745	ChEMBL	6.47	—	—	COc1cc(N2CCOCC2)ccc1Nc1nc(N)n(-c2ccc(C#N)cn2)n1
E3 Binder	CHEMBL4764582	ChEMBL	8.24	—	—	COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(C3CCN(C)CC3)nc12
E3 Binder	CHEMBL4747510	ChEMBL	7.39	—	—	COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(C3CCNCC3)nc12
E3 Binder	CHEMBL4797475	ChEMBL	8.08	—	—	COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(CCC(C)(C)O)nc12
E3 Binder	CHEMBL4781524	ChEMBL	7.02	—	—	COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(CCN(C)C)nc12
E3 Binder	CHEMBL288441	ChEMBL	6.44	DB8	—	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl
E3 Binder	CHEMBL3601197	ChEMBL	6.43	—	—	COc1cc(Nc2cc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)cn2)ccn1
E3 Binder	CHEMBL3601189	ChEMBL	8.1	—	—	COc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3601187	ChEMBL	7.05	—	—	COc1cc(Nc2ncc(-c3nc(-c4ccccc4)cs3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3601079	ChEMBL	8.7	—	—	COc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3601075	ChEMBL	8.15	—	—	COc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL24828	ChEMBL	7.12	ZD6	—	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1
E3 Binder	CHEMBL3926826	ChEMBL	6.64	—	—	COc1cc2[nH]ncc2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3343042	ChEMBL	6.24	—	—	COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)nc(NCCc3ccccn3)nc2cc1O
E3 Binder	CHEMBL4083655	ChEMBL	8.89	—	—	COc1cc2c(OC[C@@H]3CCC(=O)N3)cccc2cc1C(N)=O
E3 Binder	CHEMBL4061890	ChEMBL	8.23	—	—	COc1cc2c(OC[C@@H]3CCC(=O)N3)ccnc2cc1C(N)=O
E3 Binder	CHEMBL4536517	ChEMBL	8.68	—	—	COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(Br)c2cc1C(N)=O
E3 Binder	CHEMBL4100091	ChEMBL	8.12	—	—	COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O
E3 Binder	CHEMBL4070515	ChEMBL	8.57	—	—	COc1cc2c(OC[C@H]3NC(=O)C[C@H]3C)nccc2cc1C(N)=O
E3 Binder	CHEMBL4076912	ChEMBL	7.54	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@@H](C)[C@H]3C)nccc2cc1C(N)=O
E3 Binder	CHEMBL4093120	ChEMBL	9.52	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)nccc2cc1C(N)=O
E3 Binder	CHEMBL4075552	ChEMBL	8.32	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@@H]4C[C@H]34)nccc2cc1C(N)=O
E3 Binder	CHEMBL4084228	ChEMBL	8.62	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@@H]4[C@@H](C)[C@@H]43)nccc2cc1C(N)=O
E3 Binder	CHEMBL4085199	ChEMBL	9.22	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@@]4(F)[C@@H]3[C@@H]4C)nccc2cc1C(N)=O
E3 Binder	CHEMBL4061801	ChEMBL	8.43	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@H](C)[C@H]3C)nccc2cc1C(N)=O
E3 Binder	CHEMBL4071526	ChEMBL	8.72	—	—	COc1cc2c(OC[C@H]3NC(=O)[C@H](F)[C@H]3C)nccc2cc1C(N)=O
E3 Binder	CHEMBL3911370	ChEMBL	6.59	—	—	COc1cc2cc(C)[nH]c2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3976860	ChEMBL	6.1	—	—	COc1cc2cc[nH]c2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3962215	ChEMBL	6.22	—	—	COc1cc2cc[nH]c2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL3928107	ChEMBL	6.45	—	—	COc1cc2ccc(CO)cc2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3979848	ChEMBL	6.21	—	—	COc1cc2ccccc2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3979633	ChEMBL	8.52	—	—	COc1cc2nc(NCCO)ccc2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3904732	ChEMBL	8.0	—	—	COc1cc2nc(NCCO)ccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL5176837	ChEMBL	9.1	—	—	COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1
E3 Binder	CHEMBL3978719	ChEMBL	8.05	—	—	COc1cc2ncccc2cc1NC(=O)c1cnn2cc(O)cnc12
E3 Binder	CHEMBL3952937	ChEMBL	7.37	—	—	COc1cc2ncccc2cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL3915121	ChEMBL	7.46	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cc(CO)cnc12
E3 Binder	CHEMBL3920995	ChEMBL	6.37	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)C(C)C)nc12
E3 Binder	CHEMBL3353220	ChEMBL	8.1	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)CCN)nc12
E3 Binder	CHEMBL3924130	ChEMBL	7.54	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)CCO)nc12
E3 Binder	CHEMBL3895108	ChEMBL	6.9	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(CCO)C(C)C)nc12
E3 Binder	CHEMBL3903936	ChEMBL	7.13	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NC3CC3)nc12
E3 Binder	CHEMBL3933655	ChEMBL	6.57	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCC(C)C)nc12
E3 Binder	CHEMBL3899862	ChEMBL	7.09	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCC(O)CO)nc12
E3 Binder	CHEMBL3925304	ChEMBL	7.0	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCCCN)nc12
E3 Binder	CHEMBL3943097	ChEMBL	8.0	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCCN)nc12
E3 Binder	CHEMBL3905293	ChEMBL	7.12	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCCO)nc12
E3 Binder	CHEMBL4112700	ChEMBL	7.2	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N[C@H](C)CO)nc12
E3 Binder	CHEMBL3822972	ChEMBL	7.75	—	—	COc1cc2ncccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL402612	ChEMBL	6.74	—	—	COc1cc2ncn(-c3cccc(NC4CCNCC4)n3)c2cc1OC
E3 Binder	CHEMBL939	ChEMBL	6.27	IRE	—	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
E3 Binder	CHEMBL4579427	ChEMBL	7.48	—	—	COc1cc2nn(CC(=O)N3CCN(C)CC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1
E3 Binder	CHEMBL5176061	ChEMBL	9.7	—	—	COc1cc2nn([C@H]3CC[C@@]4(CC3)CC(=O)N(C)C4)cc2cc1C(=O)Nc1cnc2cccnn12
E3 Binder	CHEMBL5190644	ChEMBL	10.0	—	—	COc1cc2nn([C@H]3CC[C@@]4(CCC(=O)N4C)CC3)cc2cc1C(=O)Nc1cnc2cccnn12
E3 Binder	CHEMBL5204583	ChEMBL	9.52	—	—	COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)N4CC[C@@H](O)C4)CC3)cc2cc1C(=O)Nc1cnc2cccnn12
E3 Binder	CHEMBL5196239	ChEMBL	9.7	—	—	COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)[C@@H](C)O)CC3)cc2cc1C(=O)Nc1cnc2cccnn12
E3 Binder	CHEMBL5202941	ChEMBL	9.7	—	—	COc1cc2nn([C@H]3CC[C@H](N(C)C(C)=O)CC3)cc2cc1C(=O)Nc1cnc2cccnn12
E3 Binder	CHEMBL3586484	ChEMBL	6.77	—	—	COc1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C)cc3)n2)cc1
E3 Binder	CHEMBL3586485	ChEMBL	7.36	—	—	COc1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C)cc3)n2)cc1OC
E3 Binder	CHEMBL3586489	ChEMBL	6.51	—	—	COc1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C)cc3)n2)cn1
E3 Binder	CHEMBL402361	ChEMBL	8.1	—	—	COc1ccc(-c2ccc3ncc(-c4cccc(NC5CCNCC5)n4)n3c2)cn1
E3 Binder	CHEMBL3586501	ChEMBL	7.15	—	—	COc1ccc(-n2nc(C3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL1080902	ChEMBL	6.16	—	—	COc1ccc(C2=NNC(=O)/C2=N\Nc2cccc(OC)c2)cc1
E3 Binder	CHEMBL3944928	ChEMBL	8.47	—	—	COc1ccc(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)cc1
E3 Binder	CHEMBL3942983	ChEMBL	6.97	—	—	COc1ccc(Cl)cc1NC(=O)c1csc2cnc(NCCN)nc12
E3 Binder	CHEMBL4109321	ChEMBL	6.12	—	—	COc1ccc(N2CC3CC2CN3c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)cc1
E3 Binder	CHEMBL4114255	ChEMBL	7.68	—	—	COc1ccc(N2CCC3(CCN(c4nc(N[C@@H]5CCCNC5)c(-c5nc6ccccc6s5)c(=O)[nH]4)C3)C2)cc1
E3 Binder	CHEMBL4109064	ChEMBL	8.0	—	—	COc1ccc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)cc1
E3 Binder	CHEMBL4115508	ChEMBL	8.3	—	—	COc1ccc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)nc1
E3 Binder	CHEMBL1833992	ChEMBL	6.8	—	—	COc1ccc(N2CCOCC2)cc1Nc1nc(N)n(-c2ccccn2)n1
E3 Binder	CHEMBL1835740	ChEMBL	7.37	—	—	COc1ccc(Nc2nc(N)n(-c3ccccn3)n2)cc1OC
E3 Binder	CHEMBL4114351	ChEMBL	7.85	—	—	COc1ccc(OC)c(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)c1
E3 Binder	CHEMBL255935	ChEMBL	6.68	—	—	COc1ccc2c(c1)ncn2-c1cccc(NC2CCNCC2)n1
E3 Binder	CHEMBL402629	ChEMBL	8.22	—	—	COc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
E3 Binder	CHEMBL403433	ChEMBL	8.15	—	—	COc1ccc2ncc(-c3cccc(NC4CNC4)n3)n2c1
E3 Binder	CHEMBL402174	ChEMBL	7.82	—	—	COc1ccc2ncn(-c3cccc(NC4CCNCC4)n3)c2c1
E3 Binder	CHEMBL4089544	ChEMBL	7.8	—	—	COc1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c2c1
E3 Binder	CHEMBL3920407	ChEMBL	6.21	—	—	COc1cccc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)n1
E3 Binder	CHEMBL4112861	ChEMBL	8.0	—	—	COc1cccc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)n1
E3 Binder	CHEMBL4111310	ChEMBL	8.36	—	—	COc1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1
E3 Binder	CHEMBL4107317	ChEMBL	7.89	—	—	COc1ccccc1C1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL259797	ChEMBL	6.1	—	—	COc1ccccc1NC(=O)c1csc(-c2cccnc2)n1
E3 Binder	CHEMBL1835746	ChEMBL	7.11	—	—	COc1ccccc1Nc1nc(N)n(-c2cc(NCCN(C)C)ncn2)n1
E3 Binder	CHEMBL1835741	ChEMBL	6.38	—	—	COc1ccccc1Nc1nc(N)n(-c2ccccn2)n1
E3 Binder	CHEMBL4108950	ChEMBL	8.22	—	—	COc1ccnc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)c1
E3 Binder	CHEMBL4115327	ChEMBL	8.09	—	—	COc1cnc(N2CC[C@@H](Nc3cc(-n4ncc5cc(C#N)cnc54)ncc3C(=O)NC[C@@H](F)C(C)(C)O)C2)nc1
E3 Binder	CHEMBL3914088	ChEMBL	7.7	—	—	COc1cnc(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)cn1
E3 Binder	CHEMBL3939338	ChEMBL	6.59	—	—	COc1cnc2c(C(=O)Nc3cc(Cl)ccc3N3CCC(CN)CC3)cnn2c1
E3 Binder	CHEMBL3946548	ChEMBL	7.48	—	—	COc1cnc2c(C(=O)Nc3cc(Cl)ccc3N3CCC(CO)CC3)cnn2c1
E3 Binder	CHEMBL3901226	ChEMBL	6.52	—	—	COc1cnc2c(C(=O)Nc3cc(Cl)ccc3OC3CCC(O)CC3)cnn2c1
E3 Binder	CHEMBL4107905	ChEMBL	7.71	—	—	COc1cnc2c(cnn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL4106779	ChEMBL	7.5	—	—	CS(=O)(=O)C1CN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4113003	ChEMBL	7.75	—	—	CS(=O)(=O)C1CN(c2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)C1
E3 Binder	CHEMBL4112534	ChEMBL	8.25	—	—	CS(=O)(=O)N1CC2(CN(c3nc(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)c(-c4nc5ccccc5s4)c(=O)[nH]3)C2)C1
E3 Binder	CHEMBL4110755	ChEMBL	6.26	—	—	CS(=O)(=O)N1CCC(Nc2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3586502	ChEMBL	7.23	—	—	CS(=O)(=O)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C4CC4)cc3)n2)CC1
E3 Binder	CHEMBL3586504	ChEMBL	7.07	—	—	CS(=O)(=O)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C4CC4)cc3F)n2)CC1
E3 Binder	CHEMBL3586506	ChEMBL	7.7	—	—	CS(=O)(=O)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccc(C4CC4)cn3)n2)CC1
E3 Binder	CHEMBL3586500	ChEMBL	6.55	—	—	CS(=O)(=O)N1CCC(c2cc(NC(=O)c3cnn4cccnc34)n(-c3ccccc3)n2)CC1
E3 Binder	CHEMBL4108247	ChEMBL	6.42	—	—	CS(=O)(=O)N1CCC(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4088438	ChEMBL	6.92	—	—	CS(=O)(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1
E3 Binder	CHEMBL4088745	ChEMBL	8.1	—	—	CS(=O)(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
E3 Binder	CHEMBL4111648	ChEMBL	8.16	—	—	CS(=O)(=O)N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4c(C5CC5)nccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4109175	ChEMBL	7.6	—	—	CS(=O)(=O)N1CCN(c2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3921676	ChEMBL	8.36	—	—	CS(=O)(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1
E3 Binder	CHEMBL3954359	ChEMBL	8.24	—	—	CS(=O)(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1
E3 Binder	CHEMBL3956425	ChEMBL	8.77	—	—	CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1
E3 Binder	CHEMBL3973807	ChEMBL	8.46	—	—	CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1
E3 Binder	CHEMBL3985083	ChEMBL	8.41	—	—	CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2Nc2cccc(C(N)=O)c2)CC1
E3 Binder	CHEMBL4110394	ChEMBL	7.85	—	—	CS(=O)(=O)c1cc(F)ccc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4107151	ChEMBL	7.96	—	—	CS(=O)(=O)c1ccc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)c(Cl)c1
E3 Binder	CHEMBL4112091	ChEMBL	8.05	—	—	CS(=O)(=O)c1ccccc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3948840	ChEMBL	8.11	—	—	CS[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3922946	ChEMBL	6.1	—	—	CSc1ccc(Cl)cc1NC(=O)c1cnn2cccnc12
E3 Binder	CHEMBL1270795	ChEMBL	6.78	—	—	CSc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(C)ns2)n1
E3 Binder	CHEMBL3622188	ChEMBL	6.45	—	—	CSc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL3914423	ChEMBL	8.36	—	—	C[C@@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL3904382	ChEMBL	8.62	—	—	C[C@@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3928854	ChEMBL	8.21	—	—	C[C@@H](CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3981034	ChEMBL	8.28	—	—	C[C@@H](CF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL5188816	ChEMBL	8.4	—	—	C[C@@H](CF)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL3917759	ChEMBL	8.33	—	—	C[C@@H](CO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(C)(=O)=O
E3 Binder	CHEMBL3984144	ChEMBL	8.82	—	—	C[C@@H](CO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3915404	ChEMBL	8.68	—	—	C[C@@H](CO)Nc1cc(-n2ccc3cc(F)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1
E3 Binder	CHEMBL3909749	ChEMBL	8.1	—	—	C[C@@H](CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CC1
E3 Binder	CHEMBL4112802	ChEMBL	8.82	—	—	C[C@@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4113645	ChEMBL	8.57	—	—	C[C@@H](F)CNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108028	ChEMBL	8.42	—	—	C[C@@H](F)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL5198241	ChEMBL	7.68	—	—	C[C@@H](F)Cn1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL4109005	ChEMBL	8.55	—	—	C[C@@H](Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C1CC1
E3 Binder	CHEMBL4109374	ChEMBL	7.42	—	—	C[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)CN1
E3 Binder	CHEMBL3622530	ChEMBL	7.03	—	—	C[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CN1
E3 Binder	CHEMBL4110771	ChEMBL	6.82	—	—	C[C@@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CN1
E3 Binder	CHEMBL5196755	ChEMBL	7.3	—	—	C[C@@H]1C[C@@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CCN1C
E3 Binder	CHEMBL4439253	ChEMBL	7.82	—	—	C[C@@]1(CO)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL4113715	ChEMBL	6.34	—	—	C[C@@]1(O)[C@H](O)[C@@H](CO)C[C@H]1Nc1nc(NC2CCC2)[nH]c(=O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4110597	ChEMBL	8.29	—	—	C[C@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O
E3 Binder	CHEMBL4106949	ChEMBL	8.74	—	—	C[C@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4108187	ChEMBL	8.48	—	—	C[C@H](CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4107902	ChEMBL	8.34	—	—	C[C@H](CF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL5193438	ChEMBL	8.3	—	—	C[C@H](CF)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL3921810	ChEMBL	8.85	—	—	C[C@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3924209	ChEMBL	8.72	—	—	C[C@H](F)CNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL3933904	ChEMBL	8.39	—	—	C[C@H](F)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL5207654	ChEMBL	8.7	—	—	C[C@H](F)Cn1ccc2nc(Nc3cnn(C4CC5(C4)CN(C)C5)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL5190750	ChEMBL	8.7	B4U	—	C[C@H](F)Cn1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL5177080	ChEMBL	8.52	—	—	C[C@H](F)Cn1ccc2nc(Nc3cnn([C@H]4C[C@H]5C[C@@H]4CN5C)c3)nc(NC3(C)CC3)c2c1=O
E3 Binder	CHEMBL3977735	ChEMBL	8.36	—	—	C[C@H](Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C1CC1
E3 Binder	CHEMBL3902218	ChEMBL	6.27	—	—	C[C@H]1CC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)CN1
E3 Binder	CHEMBL3622529	ChEMBL	6.25	—	—	C[C@H]1CC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CN1
E3 Binder	CHEMBL3893092	ChEMBL	6.37	—	—	C[C@H]1COCCN1c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL3901315	ChEMBL	8.3	—	—	C[C@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3970853	ChEMBL	6.45	—	—	C[C@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CN1
E3 Binder	CHEMBL3936790	ChEMBL	7.64	—	—	C[C@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL5200601	ChEMBL	9.22	—	—	C[C@H]1C[C@@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CCN1C
E3 Binder	CHEMBL4466517	ChEMBL	8.29	LSV	—	C[C@]1(CO)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1
E3 Binder	CHEMBL603469	ChEMBL	8.77	2V9	—	C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O
E3 Binder	CHEMBL4107861	ChEMBL	8.22	—	—	C[N+]1=C(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC=N1
E3 Binder	CHEMBL1721885	ChEMBL	7.09	—	—	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
E3 Binder	CHEMBL5177543	ChEMBL	8.1	—	—	Cc1c[nH]c2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12
E3 Binder	CHEMBL4063689	ChEMBL	8.34	—	—	Cc1c[nH]c2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12
E3 Binder	CHEMBL5276087	ChEMBL	7.89	—	—	Cc1cc(-c2ccc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)o2)ccn1
E3 Binder	CHEMBL5267973	ChEMBL	6.92	—	—	Cc1cc(-c2nc(C(=O)Nc3c[nH]nc3C(N)=O)co2)ccn1
E3 Binder	CHEMBL4745104	ChEMBL	8.11	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4cn(CCN(C)C)nc4cc3C(C)(C)O)co2)ccn1
E3 Binder	CHEMBL4748082	ChEMBL	7.26	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3C3CC3)co2)ccn1
E3 Binder	CHEMBL4784665	ChEMBL	8.44	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCC(F)CC3)co2)ccn1
E3 Binder	CHEMBL4750630	ChEMBL	8.46	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCC(O)CC3)co2)ccn1
E3 Binder	CHEMBL4789918	ChEMBL	8.7	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCC(F)C3)co2)ccn1
E3 Binder	CHEMBL4790506	ChEMBL	8.3	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)co2)ccn1
E3 Binder	CHEMBL4757349	ChEMBL	8.05	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@@H](F)C3)co2)ccn1
E3 Binder	CHEMBL4755398	ChEMBL	7.2	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@@H](N)C3)co2)ccn1
E3 Binder	CHEMBL4783351	ChEMBL	7.5	FJ0	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@@H](O)C3)co2)ccn1
E3 Binder	CHEMBL4741488	ChEMBL	7.61	—	—	Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@H](O)C3)co2)ccn1
E3 Binder	CHEMBL5283224	ChEMBL	7.8	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(C)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL5278799	ChEMBL	7.75	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(C4CCN(C)CC4)nc3C(N)=O)co2)ccn1.Cl.Cl
E3 Binder	CHEMBL5284584	ChEMBL	7.52	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(C4CCOC4)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL3353187	ChEMBL	7.7	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL5274350	ChEMBL	7.32	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(CC(C)C)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL5286338	ChEMBL	6.82	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(CC4(C)COC4)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL5287520	ChEMBL	7.47	—	—	Cc1cc(-c2nc(C(=O)Nc3cn(CC4CCOC4)nc3C(N)=O)co2)ccn1.Cl
E3 Binder	CHEMBL5288843	ChEMBL	7.1	—	—	Cc1cc(-c2ncc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)o2)ccn1
E3 Binder	CHEMBL5282374	ChEMBL	7.62	—	—	Cc1cc(-n2ccc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)n2)ccn1
E3 Binder	CHEMBL3353192	ChEMBL	8.44	—	—	Cc1cc(C#N)cnc1Nc1cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4111747	ChEMBL	7.18	—	—	Cc1cc(C2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4ccc5ccccc5n4)c(=O)[nH]3)CC2)[nH]n1
E3 Binder	CHEMBL4111001	ChEMBL	8.1	—	—	Cc1cc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)sn1
E3 Binder	CHEMBL4113185	ChEMBL	8.21	—	—	Cc1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)[nH]n1
E3 Binder	CHEMBL4109108	ChEMBL	8.15	—	—	Cc1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)n(C)n1
E3 Binder	CHEMBL3601196	ChEMBL	7.85	—	—	Cc1cc(Nc2cc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)cn2)cc(C)n1
E3 Binder	CHEMBL3622532	ChEMBL	7.14	—	—	Cc1cc(Nc2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)cc(C)n1
E3 Binder	CHEMBL3601192	ChEMBL	9.13	—	—	Cc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL5090869	ChEMBL	6.75	—	—	Cc1cc(Nc2ncc(-c3cccnc3)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc1OCCN1CCCC1
E3 Binder	CHEMBL3601083	ChEMBL	6.07	—	—	Cc1cc(Nc2ncc(-c3cscn3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3601185	ChEMBL	8.4	—	—	Cc1cc(Nc2ncc(-c3nc(-c4ccccc4)cs3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3601186	ChEMBL	7.96	—	—	Cc1cc(Nc2ncc(-c3nc(-c4ccccc4)cs3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3353201	ChEMBL	8.66	—	—	Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(NC3C[C@H](C(C)(C)O)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3353199	ChEMBL	9.49	—	—	Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(NC3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1.Cl
E3 Binder	CHEMBL3403455	ChEMBL	6.0	—	—	Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3403454	ChEMBL	6.0	—	—	Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3403457	ChEMBL	6.52	—	—	Cc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3601080	ChEMBL	7.92	—	—	Cc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3601071	ChEMBL	8.52	—	—	Cc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
E3 Binder	CHEMBL3601085	ChEMBL	6.03	—	—	Cc1cc(Nc2ncc(-n3cccn3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
E3 Binder	CHEMBL3892637	ChEMBL	7.28	—	—	Cc1cc2cc(-c3ccc(CO)cc3)c(NC(=O)c3cnn4cccnc34)cc2[nH]1
E3 Binder	CHEMBL4113923	ChEMBL	6.04	—	—	Cc1cc2sc(-c3c(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)nc(N4CCOCC4)[nH]c3=O)nc2c(C)n1
E3 Binder	CHEMBL4109853	ChEMBL	6.06	—	—	Cc1ccc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)nc1
E3 Binder	CHEMBL3942073	ChEMBL	7.0	—	—	Cc1ccc(-n2nc(-c3ccc(S(C)(=O)=O)cc3C(F)(F)F)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586483	ChEMBL	6.16	—	—	Cc1ccc(-n2nc(-c3ccccc3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586488	ChEMBL	7.0	—	—	Cc1ccc(-n2nc(-c3cccnc3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586486	ChEMBL	7.21	—	—	Cc1ccc(-n2nc(-c3ccncc3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586490	ChEMBL	6.43	—	—	Cc1ccc(-n2nc(C3CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586495	ChEMBL	7.33	—	—	Cc1ccc(-n2nc(C3CCN(C(C)C)CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586509	ChEMBL	8.15	—	—	Cc1ccc(-n2nc(C3CCN(C(C)C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1
E3 Binder	CHEMBL3586497	ChEMBL	6.66	—	—	Cc1ccc(-n2nc(C3CCN(C(N)=O)CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586494	ChEMBL	6.82	—	—	Cc1ccc(-n2nc(C3CCN(C)CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586503	ChEMBL	7.4	—	—	Cc1ccc(-n2nc(C3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)c(F)c1
E3 Binder	CHEMBL3586498	ChEMBL	7.17	—	—	Cc1ccc(-n2nc(C3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586505	ChEMBL	7.57	—	—	Cc1ccc(-n2nc(C3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)nc1
E3 Binder	CHEMBL3586493	ChEMBL	7.1	—	—	Cc1ccc(-n2nc(C3CCNCC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586492	ChEMBL	6.39	—	—	Cc1ccc(-n2nc(C3CCOCC3)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL3586510	ChEMBL	8.3	—	—	Cc1ccc(-n2nc(N3CCN(C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1
E3 Binder	CHEMBL3586511	ChEMBL	8.7	—	—	Cc1ccc(-n2nc(N3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)nc1
E3 Binder	CHEMBL4109159	ChEMBL	7.74	—	—	Cc1ccc(CNc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL377259	ChEMBL	6.1	—	—	Cc1ccc2[nH]c(NC(=O)c3cccc([N+](=O)[O-])c3)nc2c1
E3 Binder	CHEMBL5274369	ChEMBL	8.52	—	—	Cc1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(OC3(C)CC3)c2n1
E3 Binder	CHEMBL404473	ChEMBL	8.0	—	—	Cc1ccc2ncn(-c3cccc(NC4CCNCC4)n3)c2c1
E3 Binder	CHEMBL4097259	ChEMBL	7.72	—	—	Cc1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c2c1
E3 Binder	CHEMBL4108358	ChEMBL	7.3	—	—	Cc1ccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc2c1
E3 Binder	CHEMBL4111327	ChEMBL	6.53	—	—	Cc1cccc(-c2c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)nc(N3CCCCC3)[nH]c2=O)n1
E3 Binder	CHEMBL4112994	ChEMBL	6.67	—	—	Cc1cccc(-c2c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL3941496	ChEMBL	6.24	—	—	Cc1cccc2nc(-c3c(NC4CCCNC4)nc(N4CCOCC4)[nH]c3=O)sc12
E3 Binder	CHEMBL4111161	ChEMBL	7.77	—	—	Cc1ccccc1C1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3ccc4ccccc4n3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4284323	ChEMBL	6.63	—	—	Cc1ccn2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12
E3 Binder	CHEMBL4225923	ChEMBL	6.42	—	—	Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(C(NC(C)(C)C)c3ccccn3)ns2)n1
E3 Binder	CHEMBL1650545	ChEMBL	6.0	—	—	Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1.Cl
E3 Binder	CHEMBL1739550	ChEMBL	7.25	—	—	Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(CN3CCCCC3)ns2)n1
E3 Binder	CHEMBL2022369	ChEMBL	6.06	—	—	Cc1cn2c(-c3cnn(CC(=O)NCc4cccs4)c3)cnc2c(Nc2cc(CN3CCCC(C)C3)ns2)n1
E3 Binder	CHEMBL3586507	ChEMBL	6.75	—	—	Cc1cnc(-n2nc(C3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)nc1
E3 Binder	CHEMBL4114946	ChEMBL	7.66	—	—	Cc1cnc(C)c(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)n1
E3 Binder	CHEMBL5076447	ChEMBL	8.52	—	—	Cc1cnc(Nc2cccc(C(=O)N3CCCC3)c2)nc1N[C@H]1[C@@H](C(N)=O)[C@@H]2C=C[C@H]1C2
E3 Binder	CHEMBL4112161	ChEMBL	8.15	—	—	Cc1cnc2c(cnn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1
E3 Binder	CHEMBL3932227	ChEMBL	7.87	—	—	Cc1cnc2c(cnn2-c2cc(NC(C)C)c(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cn2)c1
E3 Binder	CHEMBL4109650	ChEMBL	8.1	—	—	Cc1cnccc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4106923	ChEMBL	6.26	—	—	Cc1csc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL4106833	ChEMBL	7.03	—	—	Cc1csc(-c2c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)nc(N3CCC(C(F)(F)F)CC3)[nH]c2=O)n1
E3 Binder	CHEMBL4110611	ChEMBL	7.58	—	—	Cc1csc(-c2c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL5207689	ChEMBL	8.3	—	—	Cc1n[nH]c2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12
E3 Binder	CHEMBL5183959	ChEMBL	8.52	—	—	Cc1n[nH]c2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12
E3 Binder	CHEMBL3622184	ChEMBL	6.2	—	—	Cc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL5286869	ChEMBL	8.52	—	—	Cc1nc2c(OC3(C)CC3)nc(Nc3cnn(C4CC5(C4)CN(C)C5)c3)nc2cc1F
E3 Binder	CHEMBL4643371	ChEMBL	8.1	—	—	Cc1nc2ccc(Nc3cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn3)cc2s1
E3 Binder	CHEMBL5270356	ChEMBL	8.15	—	—	Cc1ncc(-c2ccc3nc(Nc4cnn(C5CCN(C)CC5)c4)nc(OC4(C)CC4)c3n2)c(C)n1
E3 Binder	CHEMBL5273100	ChEMBL	8.74	—	—	Cc1ncc(-c2ccc3nc(Nc4cnn(C5CCN(C)CC5)c4)nc(OC4(C)CC4)c3n2)cn1
E3 Binder	CHEMBL5274954	ChEMBL	8.7	—	—	Cc1ncc(-c2nc3c(NC(C)C)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1
E3 Binder	CHEMBL5270030	ChEMBL	9.22	—	—	Cc1ncc(-c2nc3c(NC4(C)CC4)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1
E3 Binder	CHEMBL5270903	ChEMBL	8.52	NB5	—	Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1
E3 Binder	CHEMBL5288931	ChEMBL	8.52	NBK	—	Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn(C5CCN(C)CC5)c4)nc3cc2F)cn1
E3 Binder	CHEMBL5290338	ChEMBL	8.4	—	—	Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn([C@@H]5C[C@@H]6C[C@H]5CN6C)c4)nc3cc2F)cn1
E3 Binder	CHEMBL5281809	ChEMBL	7.5	—	—	Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn([C@@H]5C[C@H]6C[C@@H]5CN6C)c4)nc3cc2F)cn1
E3 Binder	CHEMBL4107242	ChEMBL	8.24	—	—	Cc1nccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12
E3 Binder	CHEMBL4112827	ChEMBL	8.08	—	—	Cc1nccc2sc(-c3c(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)nc(N4CCOCC4)[nH]c3=O)nc12
E3 Binder	CHEMBL5270136	ChEMBL	8.3	—	—	Cc1ncncc1-c1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(OC3(C)CC3)c2n1
E3 Binder	CHEMBL5273827	ChEMBL	7.82	—	—	Cc1ncncc1-c1nc2c(OC3(C)CC3)nc(Nc3cnn(C4CCN(C)CC4)c3)nc2cc1F
E3 Binder	CHEMBL4107570	ChEMBL	7.94	—	—	Cc1nnc(-c2ccc(Nc3cc(-n4ncc5cc(C#N)cnc54)ncc3C(=O)NC[C@@H](F)C(C)(C)O)cc2)s1
E3 Binder	CHEMBL4779496	ChEMBL	7.36	—	—	Cc1nnc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)o1
E3 Binder	CHEMBL4790192	ChEMBL	6.13	—	—	Cc1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1
E3 Binder	CHEMBL4107481	ChEMBL	7.82	—	—	Cc1nonc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL4111157	ChEMBL	6.86	—	—	Cc1nsc(C2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4ccc5ccccc5n4)c(=O)[nH]3)CC2)n1
E3 Binder	CHEMBL3945308	ChEMBL	6.06	—	—	Cc1oc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)nc1NC(=O)OC(C)(C)C
E3 Binder	CHEMBL3925654	ChEMBL	8.57	—	—	Cc1sc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)nc1C(=O)NCCCN1CCCCC1
E3 Binder	CHEMBL3353189	ChEMBL	9.62	—	—	Cl.Cn1cc(NC(=O)c2coc(-c3ccnc(NCC(F)(F)F)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL3353188	ChEMBL	9.44	—	—	Cl.NC(=O)c1nn(-c2cccnc2)cc1NC(=O)c1coc(-c2ccnc(NCC(F)(F)F)c2)n1
E3 Binder	CHEMBL1650551	ChEMBL	6.19	—	—	Cl.[2H]C([2H])(c1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)N1CCC(F)(F)C1
E3 Binder	CHEMBL256942	ChEMBL	6.78	—	—	Clc1cc2ncn(-c3cccc(NC4CCNCC4)n3)c2cc1Cl
E3 Binder	CHEMBL403442	ChEMBL	6.95	—	—	Clc1ccc2c(c1)ncn2-c1cccc(NC2CCNCC2)n1
E3 Binder	CHEMBL256961	ChEMBL	8.05	—	—	Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1
E3 Binder	CHEMBL401633	ChEMBL	9.0	—	—	Clc1ccc2ncc(-c3cccc(NC4CCNC4)n3)n2c1
E3 Binder	CHEMBL256570	ChEMBL	9.0	—	—	Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
E3 Binder	CHEMBL256963	ChEMBL	8.22	—	—	Clc1ccc2ncc(-c3cccc(NC4CNC4)n3)n2c1
E3 Binder	CHEMBL436653	ChEMBL	8.52	—	—	Clc1ccc2ncn(-c3cccc(NC4CCNCC4)n3)c2c1
E3 Binder	CHEMBL4483477	ChEMBL	8.74	LRS	—	Cn1c(N2CCOCC2)nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc21
E3 Binder	CHEMBL4108172	ChEMBL	8.66	—	—	Cn1cc(-c2ccc(Nc3cc(-n4ncc5cc(C#N)cnc54)ncc3C(=O)NC[C@@H](F)C(C)(C)O)cc2)cn1
E3 Binder	CHEMBL255446	ChEMBL	8.15	—	—	Cn1cc(-c2ccc3ncc(-c4cccc(NC5CCNCC5)n4)n3c2)cn1
E3 Binder	CHEMBL4748475	ChEMBL	7.96	—	—	Cn1cc(-c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)n2)cn1
E3 Binder	CHEMBL256917	ChEMBL	6.15	—	—	Cn1cc(-c2cccc(C(=O)Nc3ccccc3Cl)n2)cn1
E3 Binder	CHEMBL3353206	ChEMBL	7.5	6YD	—	Cn1cc(-c2cccc(C(=O)Nc3cn(C)nc3C(N)=O)n2)cn1
E3 Binder	CHEMBL4550702	ChEMBL	7.19	—	—	Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
E3 Binder	CHEMBL4568087	ChEMBL	7.64	—	—	Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
E3 Binder	CHEMBL5286860	ChEMBL	7.5	—	—	Cn1cc(-c2nc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)co2)ccc1=O
E3 Binder	CHEMBL4111862	ChEMBL	7.7	—	—	Cn1cc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)cn1
E3 Binder	CHEMBL3634615	ChEMBL	9.15	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C#N)n1
E3 Binder	CHEMBL3634379	ChEMBL	8.3	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634382	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)F)n1
E3 Binder	CHEMBL3634514	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1
E3 Binder	CHEMBL3634504	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634508	ChEMBL	9.05	—	—	Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL5282803	ChEMBL	9.15	—	—	Cn1cc(NC(=O)c2ccc3cnc(NC4CCCCC4N)nn23)c(C(N)=O)n1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL3634501	ChEMBL	8.52	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nn23)c(C(F)F)n1
E3 Binder	CHEMBL3634511	ChEMBL	9.15	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL3634614	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C#N)n1
E3 Binder	CHEMBL3634378	ChEMBL	8.7	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634381	ChEMBL	9.3	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)F)n1
E3 Binder	CHEMBL3634513	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1
E3 Binder	CHEMBL3634503	ChEMBL	8.7	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634507	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4436908	ChEMBL	6.92	—	—	Cn1cc(NC(=O)c2cccc(-c3ccc(C4CC4)nc3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4534461	ChEMBL	6.67	—	—	Cn1cc(NC(=O)c2cccc(-c3cccnc3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4447180	ChEMBL	7.0	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(N)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4473472	ChEMBL	6.89	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC(F)(F)F)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4473656	ChEMBL	6.73	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)c2)c(C(N)=O)n1
E3 Binder	CHEMBL4434908	ChEMBL	6.72	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)c(C(=O)N2CC(CN)C2)n1
E3 Binder	CHEMBL4523017	ChEMBL	7.13	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4536303	ChEMBL	6.32	—	—	Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC4CCOCC4)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4436754	ChEMBL	6.4	—	—	Cn1cc(NC(=O)c2cccc(-c3ccsc3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4559589	ChEMBL	6.97	—	—	Cn1cc(NC(=O)c2cccc(-c3cncc(Cl)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4467632	ChEMBL	6.17	—	—	Cn1cc(NC(=O)c2cccc(-c3cnccc3Cl)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4518902	ChEMBL	6.18	—	—	Cn1cc(NC(=O)c2cccc(-n3cccc3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4535152	ChEMBL	6.54	—	—	Cn1cc(NC(=O)c2ccnc(-c3ccnc(NCC4CC4)c3)n2)c(C(N)=O)n1
E3 Binder	CHEMBL4788995	ChEMBL	7.09	—	—	Cn1cc(NC(=O)c2cnc3ccc(N4CCC(N)CC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4793398	ChEMBL	8.06	—	—	Cn1cc(NC(=O)c2cnc3ccc(N4CCC[C@@H](N)C4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4780605	ChEMBL	7.18	—	—	Cn1cc(NC(=O)c2cnc3ccc(N4CCNCC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4784692	ChEMBL	7.76	—	—	Cn1cc(NC(=O)c2cnc3ccc(NCCN)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4787247	ChEMBL	8.05	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4778492	ChEMBL	7.39	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C#N)n1
E3 Binder	CHEMBL4785023	ChEMBL	7.63	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1
E3 Binder	CHEMBL4791581	ChEMBL	8.89	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4785986	ChEMBL	7.9	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(N)=O)n1
E3 Binder	CHEMBL4794821	ChEMBL	8.11	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL4795391	ChEMBL	7.44	—	—	Cn1cc(NC(=O)c2cnc3ccc(N[C@H]4CCCNC4)nn23)c(C(F)F)n1
E3 Binder	CHEMBL3590436	ChEMBL	6.82	—	—	Cn1cc(NC(=O)c2cnn3ccc(CCCN)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL4784487	ChEMBL	8.03	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4CCC[C@@H](N)C4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590487	ChEMBL	8.0	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4CCNCC4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590488	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4CCNCC4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL4459066	ChEMBL	7.42	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4CCNCC4)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3590517	ChEMBL	8.22	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4CC[C@H](F)[C@@H](N)C4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590493	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)CC(F)(F)C4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590515	ChEMBL	9.3	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)CC(F)(F)C4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590516	ChEMBL	9.3	—	—	Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)C[C@@H](F)C4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590471	ChEMBL	7.02	—	—	Cn1cc(NC(=O)c2cnn3ccc(NC4CCCC4N)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3590484	ChEMBL	6.32	—	—	Cn1cc(NC(=O)c2cnn3ccc(NC4CCCCC4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590438	ChEMBL	8.7	—	—	Cn1cc(NC(=O)c2cnn3ccc(NCCN)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3590492	ChEMBL	8.52	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634384	ChEMBL	7.42	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590491	ChEMBL	8.52	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590489	ChEMBL	7.64	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590490	ChEMBL	7.89	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3634510	ChEMBL	9.7	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCCNC4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590482	ChEMBL	7.21	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(-c2ccncc2)n1
E3 Binder	CHEMBL3590483	ChEMBL	6.8	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(-c2cncnc2)n1
E3 Binder	CHEMBL3590481	ChEMBL	8.22	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(-c2nnco2)n1
E3 Binder	CHEMBL3590477	ChEMBL	9.1	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C#N)n1
E3 Binder	CHEMBL3590480	ChEMBL	8.7	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)C(F)(F)F)n1
E3 Binder	CHEMBL3590478	ChEMBL	9.52	XPY	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590479	ChEMBL	9.7	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590474	ChEMBL	9.52	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3634512	ChEMBL	7.92	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Cl)n1
E3 Binder	CHEMBL3590475	ChEMBL	7.85	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)cn1
E3 Binder	CHEMBL3590485	ChEMBL	7.68	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4O)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3590486	ChEMBL	8.4	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4O)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3634502	ChEMBL	7.92	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCNC4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634506	ChEMBL	8.6	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCNC4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3590472	ChEMBL	7.7	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CCCC[C@@H]4N)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3590473	ChEMBL	8.1	—	—	Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CCCC[C@H]4N)nc23)c(C(N)=O)n1
E3 Binder	CHEMBL3590435	ChEMBL	6.96	—	—	Cn1cc(NC(=O)c2cnn3cccnc23)c(C(N)=O)n1
E3 Binder	CHEMBL3634616	ChEMBL	9.4	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C#N)n1
E3 Binder	CHEMBL3634380	ChEMBL	9.0	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634383	ChEMBL	9.7	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)F)n1
E3 Binder	CHEMBL3634613	ChEMBL	9.52	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Cl)n1
E3 Binder	CHEMBL3634505	ChEMBL	9.1	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(C(F)(F)F)n1
E3 Binder	CHEMBL3634509	ChEMBL	9.4	—	—	Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(C(F)F)n1
E3 Binder	CHEMBL4108510	ChEMBL	8.89	—	—	Cn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4111561	ChEMBL	8.48	—	—	Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL4113759	ChEMBL	8.31	—	—	Cn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1
E3 Binder	CHEMBL5183067	ChEMBL	8.1	—	—	Cn1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1
E3 Binder	CHEMBL5179237	ChEMBL	8.7	N9Z	—	Cn1cc(Nc2nc(NC3(C)CC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL5266602	ChEMBL	7.66	—	—	Cn1cc(Nc2nc(NC3CC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL5290742	ChEMBL	6.86	—	—	Cn1cc(Nc2nc(NC3CCOCC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL5266083	ChEMBL	6.35	—	—	Cn1cc(Nc2nc(NC3COC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL5271049	ChEMBL	6.68	—	—	Cn1cc(Nc2nc(N[C@@H]3CCOC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL5272466	ChEMBL	6.95	—	—	Cn1cc(Nc2nc(N[C@H]3CCOC3)c3nc(CC#N)ccc3n2)cn1
E3 Binder	CHEMBL4452521	ChEMBL	8.7	—	—	Cn1cc(Nc2nc(N[C@H]3CC[C@H](N4CCOCC4)CC3)c3cc(C#N)ccc3n2)cn1
E3 Binder	CHEMBL4518564	ChEMBL	6.68	—	—	Cn1ccc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2c1=O
E3 Binder	CHEMBL5181320	ChEMBL	8.4	—	—	Cn1ccc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21
E3 Binder	CHEMBL4288288	ChEMBL	6.13	—	—	Cn1ccc2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c21
E3 Binder	CHEMBL258024	ChEMBL	6.3	—	—	Cn1cnc(CNc2cccc(-c3cnc4ccccn34)n2)c1
E3 Binder	CHEMBL5175829	ChEMBL	8.4	—	—	Cn1ncc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21
E3 Binder	CHEMBL4798349	ChEMBL	6.95	—	—	Cn1nccc1Cn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1
E3 Binder	CHEMBL4111673	ChEMBL	7.76	—	—	Cn1nccc1Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O
E3 Binder	CHEMBL4110352	ChEMBL	8.89	—	—	Cn1nnnc1-c1ccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1
E3 Binder	CHEMBL4108900	ChEMBL	8.52	—	—	Cn1nnnc1-c1ccc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1
E3 Binder	CHEMBL5286457	ChEMBL	7.82	—	—	N#CCc1ccc2nc(Nc3cnn(C4CCOCC4)c3)nc(NC3CCOCC3)c2n1
E3 Binder	CHEMBL3891376	ChEMBL	8.21	—	—	N#Cc1cc2cnn(-c3cc(NC4COC4)c(C(=O)NCCC4CC4)cn3)c2nc1N
E3 Binder	CHEMBL4109344	ChEMBL	7.09	—	—	N#Cc1ccc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)nc1
E3 Binder	CHEMBL5077968	ChEMBL	8.05	—	—	N#Cc1ccc(-c2cnc(Nc3cccc(C(=O)N4CCCC4)c3)nc2N[C@H]2[C@@H](C(N)=O)[C@@H]3C=C[C@H]2C3)cc1
E3 Binder	CHEMBL1835744	ChEMBL	7.44	—	—	N#Cc1ccc(-n2nc(Nc3ccccc3Cl)nc2N)nc1
E3 Binder	CHEMBL255873	ChEMBL	8.4	—	—	N#Cc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
E3 Binder	CHEMBL403210	ChEMBL	7.02	—	—	N#Cc1ccc2ncc(-c3cccc(N[C@@H]4CCCNC4)n3)n2c1
E3 Binder	CHEMBL4082572	ChEMBL	7.5	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N)CC3)c2c1
E3 Binder	CHEMBL4069200	ChEMBL	8.52	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCC(F)(F)CC4)CC3)c2c1
E3 Binder	CHEMBL4096446	ChEMBL	8.52	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCC(F)CC4)CC3)c2c1
E3 Binder	CHEMBL4060699	ChEMBL	7.46	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCC4)CC3)c2c1
E3 Binder	CHEMBL4059675	ChEMBL	7.82	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCCC4)CC3)c2c1
E3 Binder	CHEMBL4060511	ChEMBL	8.52	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCN(S(=O)(=O)C5CC5)CC4)CC3)c2c1
E3 Binder	CHEMBL4070214	ChEMBL	8.15	—	—	N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCOCC4)CC3)c2c1
E3 Binder	CHEMBL4107459	ChEMBL	8.3	—	—	N#Cc1ccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc2c1
E3 Binder	CHEMBL4109510	ChEMBL	6.78	—	—	N#Cc1cccc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL5091399	ChEMBL	7.89	—	—	N#Cc1cccc(-c2cnc(Nc3cccc(C(=O)N4CCCC4)c3)nc2N[C@H]2[C@@H](C(N)=O)[C@@H]3C=C[C@H]2C3)c1
E3 Binder	CHEMBL404471	ChEMBL	6.36	—	—	N#Cc1ccccc1Nc1cccc(-c2cnc3ccccn23)n1
E3 Binder	CHEMBL4079194	ChEMBL	7.25	—	—	N#Cc1cnc2[nH]cc(C3CCOCC3)c2c1N[C@H]1CC[C@H](N2CCOCC2)CC1
E3 Binder	CHEMBL3971772	ChEMBL	6.52	—	—	N=C(N)CNc1nc(N2CCOCC2)[nH]c(=O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3907051	ChEMBL	7.16	—	—	NC(=O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL4112163	ChEMBL	7.43	—	—	NC(=O)CNCC1CCN(c2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3361254	ChEMBL	8.12	CJQ	—	NC(=O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@H](N5CCOCC5)CC4)c3c21
E3 Binder	CHEMBL4107588	ChEMBL	7.13	—	—	NC(=O)N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL2041933	ChEMBL	6.52	YDJ	—	NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1
E3 Binder	CHEMBL3361255	ChEMBL	9.0	—	—	NC(=O)[C@@H](O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@H](N5CCOCC5)CC4)c3c21
E3 Binder	CHEMBL5204435	ChEMBL	6.15	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(C(=O)N4CCCC4)ccc3F)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5169945	ChEMBL	8.7	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5173098	ChEMBL	8.05	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc3ccn(C(F)F)c23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5208404	ChEMBL	7.82	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc3ccoc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5179113	ChEMBL	7.92	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5206477	ChEMBL	7.75	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc3ncsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5084123	ChEMBL	7.92	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5081576	ChEMBL	7.43	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(-c4cnco4)cc3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5170107	ChEMBL	8.0	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(C(=O)N4CCCC4)cc3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5082986	ChEMBL	7.58	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(C(=O)N4CCCC4)cc3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5184991	ChEMBL	7.85	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(C(=O)N4CCOCC4)cc3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5175590	ChEMBL	8.52	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(F)c(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5181632	ChEMBL	7.02	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(F)c(N4CCOCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5084495	ChEMBL	7.6	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(N4CCOCC4)nc3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5201330	ChEMBL	7.31	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(OCCN4CCCC4)cc3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5085436	ChEMBL	6.99	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5073141	ChEMBL	7.6	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(-c4cnco4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5178542	ChEMBL	7.82	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCC(F)C4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5189048	ChEMBL	7.96	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3[nH]ccc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5208062	ChEMBL	8.3	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3[nH]cnc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5198583	ChEMBL	8.4	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3[nH]ncc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5184745	ChEMBL	8.22	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3cc[nH]c23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5178272	ChEMBL	8.3	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccccc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5187995	ChEMBL	8.7	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccn(C(F)F)c23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5192205	ChEMBL	8.52	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccoc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5185144	ChEMBL	8.52	SO9	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5209423	ChEMBL	7.77	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3cn[nH]c23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5187663	ChEMBL	8.52	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ncsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5087312	ChEMBL	7.72	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccc(F)cc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5082615	ChEMBL	7.96	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5085979	ChEMBL	8.0	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccccc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5088588	ChEMBL	8.4	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccccc2F)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5094876	ChEMBL	8.0	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5094640	ChEMBL	8.52	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccnc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5071152	ChEMBL	8.0	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccncc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5075301	ChEMBL	8.7	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccoc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5079990	ChEMBL	8.3	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccsc2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5079737	ChEMBL	8.3	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cncc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5090193	ChEMBL	8.22	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2C2CC2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5201935	ChEMBL	8.22	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCOCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5091019	ChEMBL	7.85	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5181489	ChEMBL	6.69	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5094391	ChEMBL	7.48	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5170085	ChEMBL	8.0	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCOCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5093825	ChEMBL	8.1	—	—	NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2
E3 Binder	CHEMBL5187233	ChEMBL	7.77	—	—	NC(=O)[C@H]1CCC[C@H]1Nc1nc(Nc2cccc(C(=O)N3CCCC3)c2)nc2ccsc12
E3 Binder	CHEMBL4060298	ChEMBL	6.33	—	—	NC(=O)c1ccc(Nc2cc(NCc3ccccc3)c(C(N)=O)cn2)cc1
E3 Binder	CHEMBL403358	ChEMBL	8.3	—	—	NC(=O)c1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
E3 Binder	CHEMBL4111047	ChEMBL	8.0	—	—	NC(=O)c1ccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc2c1
E3 Binder	CHEMBL5202575	ChEMBL	7.72	—	—	NC(=O)c1ccccc1Nc1nc(Nc2cccc(C(=O)N3CCCC3)c2)nc2ccsc12
E3 Binder	CHEMBL4088523	ChEMBL	6.41	—	—	NC(=O)c1cnc(Nc2ccc3[nH]ncc3c2)cc1NCc1ccccc1
E3 Binder	CHEMBL4098698	ChEMBL	6.44	9YY	—	NC(=O)c1cnc(Nc2ccc3c(c2)CC(=O)N3)cc1NCc1ccccc1
E3 Binder	CHEMBL4068975	ChEMBL	6.75	—	—	NC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NCc1cc(F)ccc1F
E3 Binder	CHEMBL4069401	ChEMBL	7.7	—	—	NC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO
E3 Binder	CHEMBL4104005	ChEMBL	7.72	—	—	NC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4099198	ChEMBL	6.14	—	—	NC(=O)c1cnc(Nc2ccccc2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4080656	ChEMBL	6.08	—	—	NC(=O)c1cnc(Nc2ccccc2)cc1N[C@H](CO)c1ccccc1
E3 Binder	CHEMBL3953542	ChEMBL	6.97	—	—	NC(=O)c1cnc2c(C(=O)Nc3cc(Cl)ccc3OC3CCC(O)CC3)cnn2c1
E3 Binder	CHEMBL3890971	ChEMBL	6.69	—	—	NC(=O)c1cnc2c(C(=O)Nc3cc(Cl)ccc3O[C@H]3CC[C@@H](O)CC3)cnn2c1
E3 Binder	CHEMBL5276741	ChEMBL	7.58	—	—	NC(=O)c1nn(C2CCOCC2)cc1NC(=O)c1coc(-c2ccc(F)cc2)n1
E3 Binder	CHEMBL5275179	ChEMBL	7.17	—	—	NC(=O)c1nn(C2CCOCC2)cc1NC(=O)c1coc(-c2ccnc(C3CC3)c2)n1
E3 Binder	CHEMBL5290771	ChEMBL	7.28	—	—	NC(=O)c1nn(C2CCOCC2)cc1NC(=O)c1coc(-c2ccnc(CO)c2)n1
E3 Binder	CHEMBL5268077	ChEMBL	7.09	—	—	NC(=O)c1nn(C2CCOCC2)cc1NC(=O)c1coc(-c2ccncc2F)n1
E3 Binder	CHEMBL5283042	ChEMBL	8.52	—	—	NC(=O)c1nn(CCO)cc1NC(=O)c1ccc2cnc(NC3CCCCC3N)nn12.O=C(O)C(F)(F)F
E3 Binder	CHEMBL3892921	ChEMBL	7.61	—	—	NC(=O)c1nnc(-c2cnc(Nc3ccc4ncsc4c3)cc2N[C@H](CO)Cc2ccccc2)o1
E3 Binder	CHEMBL3941139	ChEMBL	7.28	—	—	NC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3622522	ChEMBL	6.59	—	—	NC1CCCC(Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)C1
E3 Binder	CHEMBL3982860	ChEMBL	6.64	—	—	NC1CCCCC1Nc1nc(N2CCOCC2)[nH]c(=O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL404142	ChEMBL	6.27	—	—	NC1CCCN(c2cccc(-c3cnc4ccccn34)n2)C1
E3 Binder	CHEMBL3909791	ChEMBL	6.12	—	—	NC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)C1
E3 Binder	CHEMBL3902377	ChEMBL	6.6	—	—	NC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL4115340	ChEMBL	6.62	—	—	NC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1
E3 Binder	CHEMBL3951738	ChEMBL	6.88	—	—	NCC1CCN(c2c(N)cccc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3920056	ChEMBL	8.4	—	—	NCC1CCN(c2cc(C(=O)Nc3ccccc3)ccc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3950656	ChEMBL	8.7	LTY	—	NCC1CCN(c2cc3ncccc3cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3953525	ChEMBL	7.92	—	—	NCC1CCN(c2cc3ncccc3cc2NC(=O)c2csc3cncnc23)CC1
E3 Binder	CHEMBL3353219	ChEMBL	9.0	—	—	NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1
E3 Binder	CHEMBL3938296	ChEMBL	6.25	—	—	NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)C1
E3 Binder	CHEMBL3960537	ChEMBL	7.51	—	—	NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1
E3 Binder	CHEMBL3944795	ChEMBL	6.78	—	—	NCC1CCN(c2ccc(Cl)cc2NC(=O)c2csc3cncnc23)CC1
E3 Binder	CHEMBL3983893	ChEMBL	6.99	—	—	NCCCOc1cc2ncccc2cc1NC(=O)c1csc2cncnc12
E3 Binder	CHEMBL3353204	ChEMBL	7.8	—	—	NCCNc1cccc2nc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)sc12
E3 Binder	CHEMBL4109051	ChEMBL	7.8	—	—	NCCNc1cccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12
E3 Binder	CHEMBL5277765	ChEMBL	8.7	—	—	NCCNc1ncc2ccc(C(=O)Nc3cn(CCO)nc3C(N)=O)n2n1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL3976077	ChEMBL	7.09	—	—	NCc1ccc(-c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)cc1
E3 Binder	CHEMBL4108331	ChEMBL	7.62	—	—	N[C@@H]1CCCC[C@@H]1Nc1cccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12
E3 Binder	CHEMBL3353205	ChEMBL	8.7	—	—	N[C@H]1CCCC[C@H]1Nc1cccc2nc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)sc12
E3 Binder	CHEMBL4113995	ChEMBL	8.7	—	—	N[C@H]1CCCC[C@H]1Nc1cccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12
E3 Binder	CHEMBL4791469	ChEMBL	6.98	—	—	N[C@H]1CCN(c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)n2)C1
E3 Binder	CHEMBL3601193	ChEMBL	6.95	—	—	Nc1cc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)cn1
E3 Binder	CHEMBL4757687	ChEMBL	8.1	—	—	Nc1ccc(-c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4cc3N3CCCCC3)n2)cn1
E3 Binder	CHEMBL4743091	ChEMBL	8.55	—	—	Nc1ccc(-c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)n2)cn1
E3 Binder	CHEMBL4790504	ChEMBL	6.4	—	—	Nc1ccc(-c2cccc(C(=O)Nc3ccc4nc(N5CCOCC5)oc4c3)n2)cn1
E3 Binder	CHEMBL4111179	ChEMBL	7.31	—	—	Nc1ccc2c(c1)CN(c1nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]1)CC2
E3 Binder	CHEMBL3974236	ChEMBL	6.81	—	—	Nc1cccc(NC(=O)c2cnn3cccnc23)c1N1CCCCC1
E3 Binder	CHEMBL2018055	ChEMBL	6.77	—	—	Nc1nc(Cl)c(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL4108513	ChEMBL	6.16	—	—	Nc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(=O)[nH]1
E3 Binder	CHEMBL1835743	ChEMBL	6.36	—	—	Nc1nc(Nc2cc(N3CCOCC3)ccc2F)nn1-c1ccccn1
E3 Binder	CHEMBL3403443	ChEMBL	6.98	—	—	Nc1ncc(-c2ccc3ccccc3n2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL3403436	ChEMBL	6.08	—	—	Nc1ncc(-c2ccccn2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL3403445	ChEMBL	6.39	—	—	Nc1ncc(-c2nc(-c3ccccc3)cs2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL2018064	ChEMBL	6.62	—	—	Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL3403439	ChEMBL	6.28	—	—	Nc1ncc(-c2nc3cccnc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL3403440	ChEMBL	7.8	—	—	Nc1ncc(-c2nc3ccncc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL3403441	ChEMBL	7.62	—	—	Nc1ncc(-c2nc3cnccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
E3 Binder	CHEMBL4091402	ChEMBL	7.3	—	—	O=C(NC1CC1)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL4112383	ChEMBL	7.0	—	—	O=C(NC1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1)OCc1ccccc1
E3 Binder	CHEMBL4569508	ChEMBL	6.68	—	—	O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
E3 Binder	CHEMBL4096937	ChEMBL	7.16	—	—	O=C(NCC1CC1)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)Cc1ccccc1
E3 Binder	CHEMBL3950081	ChEMBL	6.7	—	—	O=C(Nc1cc(CO)ccc1N1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3958762	ChEMBL	6.66	—	—	O=C(Nc1cc(Cl)ccc1-c1ccc(CO)cc1)c1cnn2cccnc12
E3 Binder	CHEMBL3926861	ChEMBL	6.32	—	—	O=C(Nc1cc(Cl)ccc1-c1ccc(O)cc1)c1cnn2cccnc12
E3 Binder	CHEMBL3931566	ChEMBL	6.27	—	—	O=C(Nc1cc(Cl)ccc1-c1ccccc1)c1cnn2cccnc12
E3 Binder	CHEMBL3963416	ChEMBL	6.1	—	—	O=C(Nc1cc(Cl)ccc1C1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3892585	ChEMBL	6.19	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3944798	ChEMBL	7.75	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1cnn2cc(O)cnc12
E3 Binder	CHEMBL3919571	ChEMBL	7.14	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3917961	ChEMBL	7.55	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1cnn2nc(O)cnc12
E3 Binder	CHEMBL3891503	ChEMBL	7.16	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1csc2cccnc12
E3 Binder	CHEMBL3898083	ChEMBL	7.0	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1csc2cncnc12
E3 Binder	CHEMBL3918045	ChEMBL	6.31	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(O)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3980609	ChEMBL	6.87	—	—	O=C(Nc1cc(Cl)ccc1N1CCC(O)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3962911	ChEMBL	6.32	—	—	O=C(Nc1cc(Cl)ccc1N1CCCC(O)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3947085	ChEMBL	6.51	—	—	O=C(Nc1cc(Cl)ccc1N1CCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3924734	ChEMBL	6.5	—	—	O=C(Nc1cc(Cl)ccc1N1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3930442	ChEMBL	7.62	—	—	O=C(Nc1cc(Cl)ccc1N1CCCCC1)c1cnn2nc(O)cnc12
E3 Binder	CHEMBL3903575	ChEMBL	6.28	—	—	O=C(Nc1cc(Cl)ccc1N1CCOCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3900722	ChEMBL	6.14	—	—	O=C(Nc1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12
E3 Binder	CHEMBL3919293	ChEMBL	6.51	—	—	O=C(Nc1cc(Cl)ccc1OC1CCC(CO)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3929903	ChEMBL	6.44	—	—	O=C(Nc1cc(Cl)ccc1OC1CCC(O)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3909577	ChEMBL	6.86	—	—	O=C(Nc1cc(Cl)ccc1OC1CCC(O)CC1)c1cnn2cc(Br)cnc12
E3 Binder	CHEMBL3939426	ChEMBL	7.64	—	—	O=C(Nc1cc(Cl)ccc1OC1CCC(O)CC1)c1cnn2cc(O)cnc12
E3 Binder	CHEMBL3907425	ChEMBL	6.34	—	—	O=C(Nc1cc(Cl)ccc1OC1CCC(O)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3915142	ChEMBL	6.22	—	—	O=C(Nc1cc(Cl)ccc1OC1CCCC(O)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3931955	ChEMBL	6.32	—	—	O=C(Nc1cc(Cl)ccc1OC1CCNCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3902407	ChEMBL	6.32	—	—	O=C(Nc1cc(Cl)ccc1OC1CCNCC1)c1csc2cccnc12
E3 Binder	CHEMBL3945929	ChEMBL	6.3	—	—	O=C(Nc1cc(Cl)ccc1OCCC(O)CO)c1cnn2cccnc12
E3 Binder	CHEMBL3944326	ChEMBL	6.36	—	—	O=C(Nc1cc(Cl)ccc1OCCCCO)c1cnn2cccnc12
E3 Binder	CHEMBL3898402	ChEMBL	6.37	—	—	O=C(Nc1cc(Cl)ccc1OCCCO)c1cnn2cccnc12
E3 Binder	CHEMBL3940589	ChEMBL	6.29	—	—	O=C(Nc1cc(Cl)ccc1OCc1cnco1)c1cnn2cccnc12
E3 Binder	CHEMBL3941034	ChEMBL	6.83	—	—	O=C(Nc1cc(Cl)ccc1O[C@H]1CC[C@@H](O)CC1)c1csc2cncnc12
E3 Binder	CHEMBL3900127	ChEMBL	6.47	—	—	O=C(Nc1cc(Cl)ccc1O[C@H]1CC[C@H](O)CC1)c1csc2cncnc12
E3 Binder	CHEMBL4460055	ChEMBL	8.77	—	—	O=C(Nc1cc2[nH]c(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL4554579	ChEMBL	8.17	—	—	O=C(Nc1cc2[nH]cnc2cc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL4452765	ChEMBL	9.33	—	—	O=C(Nc1cc2c(cc1N1CCOCC1)C(=O)N(CC1CCOCC1)C2)c1cnn2cccnc12
E3 Binder	CHEMBL4460458	ChEMBL	6.54	—	—	O=C(Nc1cc2ccc(N3CCOCC3)nc2cc1N1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3982232	ChEMBL	6.75	—	—	O=C(Nc1cc2ccccc2cc1OC1CCC(O)C1)c1cnn2cccnc12
E3 Binder	CHEMBL3937613	ChEMBL	6.91	—	—	O=C(Nc1cc2ccccc2cc1OC1CCC(O)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3955819	ChEMBL	6.49	—	—	O=C(Nc1cc2ccccc2cc1OCCCO)c1cnn2cccnc12
E3 Binder	CHEMBL4453861	ChEMBL	8.77	—	—	O=C(Nc1cc2cccnc2cc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3895793	ChEMBL	8.1	—	—	O=C(Nc1cc2cccnc2cc1N1CCCCC1)c1cnn2ccccc12
E3 Binder	CHEMBL4569648	ChEMBL	8.1	—	—	O=C(Nc1cc2cccnc2cc1N1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3929293	ChEMBL	7.92	—	—	O=C(Nc1cc2cccnc2cc1N1CCCCC1)c1csc2cncnc12
E3 Binder	CHEMBL3951842	ChEMBL	7.54	—	—	O=C(Nc1cc2cccnc2cc1OC1CCC(O)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL3902455	ChEMBL	7.62	—	—	O=C(Nc1cc2cccnc2cc1OC1CCC(O)CC1)c1csc2cncnc12
E3 Binder	CHEMBL3919932	ChEMBL	6.34	—	—	O=C(Nc1cc2cccnc2cc1OC1CCNC1)c1csc2cncnc12
E3 Binder	CHEMBL3957189	ChEMBL	7.4	—	—	O=C(Nc1cc2cccnc2cc1OC1CCNCC1)c1cnn2cccnc12
E3 Binder	CHEMBL3967276	ChEMBL	6.9	—	—	O=C(Nc1cc2cccnc2cc1OC1CCNCC1)c1csc2cncnc12
E3 Binder	CHEMBL3919594	ChEMBL	6.88	—	—	O=C(Nc1cc2cccnc2cc1OCCCO)c1csc2cncnc12
E3 Binder	CHEMBL4108668	ChEMBL	7.82	—	—	O=C(Nc1cc2cccnc2cc1O[C@@H]1CC[C@@H](O)C1)c1csc2cncnc12
E3 Binder	CHEMBL3975753	ChEMBL	6.91	—	—	O=C(Nc1cc2cccnc2cc1O[C@@H]1CC[C@H](O)C1)c1csc2cncnc12
E3 Binder	CHEMBL3967068	ChEMBL	8.15	—	—	O=C(Nc1cc2cccnc2cc1O[C@H]1CC[C@@H](O)CC1)c1csc2cncnc12
E3 Binder	CHEMBL3972673	ChEMBL	7.96	—	—	O=C(Nc1cc2cccnc2cc1O[C@H]1CC[C@H](O)CC1)c1csc2cncnc12
E3 Binder	CHEMBL4544284	ChEMBL	6.77	—	—	O=C(Nc1cc2cnc(N3CCOCC3)nc2cc1N1CCCCC1)c1cnn2cccnc12
E3 Binder	CHEMBL4515682	ChEMBL	8.92	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL4760206	ChEMBL	8.57	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2cc1N1CCCCC1)c1cccc(-c2cn[nH]c2)n1
E3 Binder	CHEMBL4790895	ChEMBL	6.3	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2nc1C1CC1)c1coc(N2CC[C@H](O)C2)n1
E3 Binder	CHEMBL4742305	ChEMBL	7.99	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2nc1N1CCCCC1)c1cccc(-c2cn[nH]c2)n1
E3 Binder	CHEMBL4757094	ChEMBL	7.38	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2nc1N1CCCCC1)c1cccc(N2CC[C@H](O)C2)n1
E3 Binder	CHEMBL4796558	ChEMBL	8.44	—	—	O=C(Nc1cc2oc(N3CCOCC3)nc2nc1N1CCCCC1)c1coc(N2CC[C@H](O)C2)n1
E3 Binder	CHEMBL4474636	ChEMBL	9.3	—	—	O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12
E3 Binder	CHEMBL4568867	ChEMBL	9.1	—	—	O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCOCC1)c1cnn2cccnc12
E3 Binder	CHEMBL4788562	ChEMBL	6.1	—	—	O=C(Nc1ccc2nc(N3CCOCC3)oc2c1)c1cccc(-c2cccnc2)n1
E3 Binder	CHEMBL3975532	ChEMBL	6.52	—	—	O=C(Nc1ccc2ncccc2c1)c1csc2cnc(NCCO)nc12
E3 Binder	CHEMBL256719	ChEMBL	6.18	—	—	O=C(Nc1ccccc1Cl)c1cccc(-c2cn[nH]c2)n1
E3 Binder	CHEMBL408383	ChEMBL	6.0	—	—	O=C(Nc1ccccc1OC(F)F)c1csc(-c2cccnc2)n1
E3 Binder	CHEMBL4799964	ChEMBL	7.28	—	—	O=C(Nc1cn(C2CCNCC2)nc1C(F)(F)F)c1cnc2ccc(N[C@@H]3CCCNC3)nn12
E3 Binder	CHEMBL4780218	ChEMBL	7.3	—	—	O=C(Nc1cn(C2CCOCC2)nc1C(F)(F)F)c1cnc2ccc(N[C@@H]3CCCNC3)nn12
E3 Binder	CHEMBL3734872	ChEMBL	9.3	—	—	O=C(Nc1nc2cc(CN3CCCC3=O)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3736465	ChEMBL	8.89	—	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccc(CCO)cc1)c1cccc(C(F)(F)F)c1
E3 Binder	CHEMBL3736278	ChEMBL	8.55	—	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc(C(F)(F)F)c1
E3 Binder	CHEMBL3735719	ChEMBL	8.09	T20	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3736036	ChEMBL	9.38	—	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1
E3 Binder	CHEMBL3734854	ChEMBL	9.15	—	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735673	ChEMBL	8.55	—	—	O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735523	ChEMBL	8.42	—	—	O=C(Nc1nc2cc(CN3CCOCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735975	ChEMBL	7.96	—	—	O=C(Nc1nc2cc(CO)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735096	ChEMBL	7.42	—	—	O=C(Nc1nc2cc(F)ccc2n1CCCO)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735247	ChEMBL	8.11	—	—	O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@@H](CO)C1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735949	ChEMBL	8.8	—	—	O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3736469	ChEMBL	7.96	—	—	O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@H](CO)C1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3735044	ChEMBL	8.19	—	—	O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@H](CO)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3734846	ChEMBL	8.19	—	—	O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL3734814	ChEMBL	9.32	—	—	O=C(Nc1nc2ccc(CO)cc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1
E3 Binder	CHEMBL207464	ChEMBL	6.26	—	—	O=C(Nc1nc2ccccc2n1C1CCOC1=O)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL210983	ChEMBL	6.3	—	—	O=C(Nc1nc2ccccc2n1CC1CCCO1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL379787	ChEMBL	6.7	—	—	O=C(Nc1nc2ccccc2n1CCN1CCOCC1)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL379985	ChEMBL	6.4	—	—	O=C(Nc1nc2ccccc2n1CCO)c1cccc([N+](=O)[O-])c1
E3 Binder	CHEMBL4106733	ChEMBL	6.6	—	—	O=C(O)C1CN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CCO1
E3 Binder	CHEMBL3353210	ChEMBL	7.0	—	—	O=C(c1ccc(-n2cc(-c3n[nH]c4ccccc34)nn2)cc1)N1CCOCC1
E3 Binder	CHEMBL1908397	ChEMBL	6.17	—	—	O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1
E3 Binder	CHEMBL256735	ChEMBL	6.58	—	—	O=C(c1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1)N1CCOCC1
E3 Binder	CHEMBL5187947	ChEMBL	7.01	—	—	O=C(c1cccc(Nc2nc(NC3C[C@@H]4CC[C@H]3C4)c3sccc3n2)c1)N1CCC(F)C1
E3 Binder	CHEMBL4107488	ChEMBL	6.59	—	—	O=C1CCCN1c1cccc(-c2c(N[C@@H]3CCCNC3)nc(N3CCOCC3)[nH]c2=O)n1
E3 Binder	CHEMBL3622526	ChEMBL	6.35	—	—	O=C1CC[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2nc3ccccc3s2)CN1
E3 Binder	CHEMBL4112779	ChEMBL	6.71	—	—	O=C1CNC2(CCN(c3nc(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)O1
E3 Binder	CHEMBL3981674	ChEMBL	7.31	—	—	O=C1Cc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc2N1
E3 Binder	CHEMBL3965265	ChEMBL	7.01	—	—	O=C1Cc2cc(N3CCCCC3)c(NC(=O)c3cnn4cccnc34)cc2N1
E3 Binder	CHEMBL4113648	ChEMBL	6.14	—	—	O=c1[nH]c(C2CCN(C3CCC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107435	ChEMBL	6.21	—	—	O=c1[nH]c(C2CCN(C3CCCC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112221	ChEMBL	6.35	—	—	O=c1[nH]c(C2CCN(C3CCCCC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113086	ChEMBL	6.75	—	—	O=c1[nH]c(C2CCN(C3CCOC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4106963	ChEMBL	6.36	—	—	O=c1[nH]c(C2CCN(C3CCOCC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111214	ChEMBL	6.47	—	—	O=c1[nH]c(C2CCN(CC3CC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108284	ChEMBL	6.77	—	—	O=c1[nH]c(C2CCN(S(=O)(=O)C3CC3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3961880	ChEMBL	6.75	—	—	O=c1[nH]c(C2CCN(c3ccccn3)CC2)nc(NC2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112564	ChEMBL	7.05	—	—	O=c1[nH]c(C2CCN(c3cccnc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115128	ChEMBL	6.75	—	—	O=c1[nH]c(C2CCN(c3cnccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107847	ChEMBL	6.58	—	—	O=c1[nH]c(C2CCN(c3ncccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113026	ChEMBL	6.42	—	—	O=c1[nH]c(C2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111100	ChEMBL	7.77	—	—	O=c1[nH]c(N2CC(F)[C@@H](F)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4108780	ChEMBL	7.75	—	—	O=c1[nH]c(N2CC(O)(C(F)(F)F)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4114620	ChEMBL	8.19	—	—	O=c1[nH]c(N2CC3(CNC3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3955522	ChEMBL	7.6	—	—	O=c1[nH]c(N2CC3(COC3)C2)nc(NC2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109337	ChEMBL	8.05	—	—	O=c1[nH]c(N2CC3(COC3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111164	ChEMBL	6.77	—	—	O=c1[nH]c(N2CC3CC2CN3)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4109957	ChEMBL	6.86	—	—	O=c1[nH]c(N2CC3CC2CS(=O)(=O)C3)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4113418	ChEMBL	7.47	—	—	O=c1[nH]c(N2CC3CC3C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL3928207	ChEMBL	7.37	—	—	O=c1[nH]c(N2CC3CCC(C2)O3)nc(NC2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113183	ChEMBL	7.21	—	—	O=c1[nH]c(N2CCC(CO)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108397	ChEMBL	6.92	—	—	O=c1[nH]c(N2CCC(Cn3cccn3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112969	ChEMBL	7.11	—	—	O=c1[nH]c(N2CCC(F)(F)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622515	ChEMBL	6.87	—	—	O=c1[nH]c(N2CCC(F)(F)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112885	ChEMBL	6.96	—	—	O=c1[nH]c(N2CCC(NCc3ccccc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4106994	ChEMBL	7.7	—	—	O=c1[nH]c(N2CCC(O)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4115026	ChEMBL	7.35	—	—	O=c1[nH]c(N2CCC(c3cccc(F)n3)CC2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4112653	ChEMBL	7.8	—	—	O=c1[nH]c(N2CCC(c3ccccc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4115028	ChEMBL	7.5	—	—	O=c1[nH]c(N2CCC(c3ccccc3C(F)(F)F)CC2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4107519	ChEMBL	6.71	—	—	O=c1[nH]c(N2CCC(c3ccccn3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109711	ChEMBL	7.92	—	—	O=c1[nH]c(N2CCC(c3ccccn3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112769	ChEMBL	7.88	—	—	O=c1[nH]c(N2CCC(c3cccnc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4106558	ChEMBL	7.51	—	—	O=c1[nH]c(N2CCC(c3ccncc3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109857	ChEMBL	7.72	—	—	O=c1[nH]c(N2CCC(c3ccncc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4106730	ChEMBL	7.9	—	—	O=c1[nH]c(N2CCC(c3cnccn3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112396	ChEMBL	8.21	—	—	O=c1[nH]c(N2CCC(c3cncnc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108757	ChEMBL	7.93	—	—	O=c1[nH]c(N2CCC(n3ccnn3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622513	ChEMBL	7.17	—	—	O=c1[nH]c(N2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115124	ChEMBL	7.4	—	—	O=c1[nH]c(N2CCC3(CC2)CNC3)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111625	ChEMBL	7.57	—	—	O=c1[nH]c(N2CCC3(CCN(Cc4ccccc4)C3)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107129	ChEMBL	7.64	—	—	O=c1[nH]c(N2CCC3(CCN(S(=O)(=O)c4ccccc4)C3)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113697	ChEMBL	7.33	—	—	O=c1[nH]c(N2CCC3(CCN(c4ccc(Cl)cc4)C3)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114391	ChEMBL	7.68	—	—	O=c1[nH]c(N2CCC3(CCN(c4ccccc4)C3)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107849	ChEMBL	7.92	—	—	O=c1[nH]c(N2CCC3(CCN(c4ncccn4)C3)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113046	ChEMBL	6.48	—	—	O=c1[nH]c(N2CCC3CCCCC3C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3967770	ChEMBL	7.62	—	—	O=c1[nH]c(N2CCCC2)nc(NC2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4115029	ChEMBL	7.85	—	—	O=c1[nH]c(N2CCCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2c(C3CC3)nccc2s1
E3 Binder	CHEMBL4112758	ChEMBL	7.96	—	—	O=c1[nH]c(N2CCCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622512	ChEMBL	7.75	—	—	O=c1[nH]c(N2CCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3932684	ChEMBL	7.27	—	—	O=c1[nH]c(N2CCCCC2)nc(NC2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4110413	ChEMBL	8.07	—	—	O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2c(C3CC3)nccc2s1
E3 Binder	CHEMBL4115147	ChEMBL	7.15	—	—	O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114295	ChEMBL	7.64	—	—	O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4113814	ChEMBL	7.65	—	—	O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL3622514	ChEMBL	7.37	—	—	O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112330	ChEMBL	7.07	—	—	O=c1[nH]c(N2CCC[C@H]2CF)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4114067	ChEMBL	6.65	—	—	O=c1[nH]c(N2CCN(Cc3nccs3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112572	ChEMBL	8.05	—	—	O=c1[nH]c(N2CCN(c3cc(Cl)ccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107379	ChEMBL	7.96	—	—	O=c1[nH]c(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115196	ChEMBL	7.24	—	—	O=c1[nH]c(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112990	ChEMBL	8.1	—	—	O=c1[nH]c(N2CCN(c3ccc(Cl)cn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112018	ChEMBL	7.96	—	—	O=c1[nH]c(N2CCN(c3ccc4c(c3)OCO4)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107958	ChEMBL	7.38	—	—	O=c1[nH]c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109180	ChEMBL	7.6	—	—	O=c1[nH]c(N2CCN(c3cccc(Cl)n3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111358	ChEMBL	7.35	—	—	O=c1[nH]c(N2CCN(c3ccccc3C(F)(F)F)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109283	ChEMBL	7.57	—	—	O=c1[nH]c(N2CCN(c3ccccc3Cl)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114283	ChEMBL	7.8	—	—	O=c1[nH]c(N2CCN(c3ccccc3F)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4110364	ChEMBL	8.1	—	—	O=c1[nH]c(N2CCN(c3ccccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109750	ChEMBL	7.7	—	—	O=c1[nH]c(N2CCN(c3cccnc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL3353202	ChEMBL	8.22	—	—	O=c1[nH]c(N2CCN(c3cccnc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109600	ChEMBL	8.43	—	—	O=c1[nH]c(N2CCN(c3cccnc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4110266	ChEMBL	8.1	—	—	O=c1[nH]c(N2CCN(c3cnccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107171	ChEMBL	7.77	—	—	O=c1[nH]c(N2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108607	ChEMBL	7.68	—	—	O=c1[nH]c(N2CCN(c3ncccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL4109605	ChEMBL	8.0	—	—	O=c1[nH]c(N2CCN(c3ncccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111572	ChEMBL	7.92	—	—	O=c1[nH]c(N2CCN(c3nccs3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115314	ChEMBL	7.57	—	—	O=c1[nH]c(N2CCN(c3nnc(C4CC4)o3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115348	ChEMBL	7.7	—	—	O=c1[nH]c(N2CCN(c3nncs3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107634	ChEMBL	6.7	—	—	O=c1[nH]c(N2CCOC(C(F)(F)F)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111657	ChEMBL	7.24	—	—	O=c1[nH]c(N2CCOC(CCO)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107195	ChEMBL	7.37	—	—	O=c1[nH]c(N2CCOC(CO)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3892724	ChEMBL	6.96	—	—	O=c1[nH]c(N2CCOCC2)nc(NC(CO)CO)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3895042	ChEMBL	6.21	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CCC(O)CC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3971525	ChEMBL	7.57	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CCCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3949920	ChEMBL	6.61	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3919163	ChEMBL	6.75	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622527	ChEMBL	6.92	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CCNCC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3942146	ChEMBL	7.3	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CN3CCC2CC3)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3893206	ChEMBL	6.82	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL3931358	ChEMBL	6.52	—	—	O=c1[nH]c(N2CCOCC2)nc(NC2CNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3962227	ChEMBL	6.47	—	—	O=c1[nH]c(N2CCOCC2)nc(NCC2CCCCN2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL3957399	ChEMBL	6.48	—	—	O=c1[nH]c(N2CCOCC2)nc(NCC2CCNCC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3917833	ChEMBL	6.11	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCN2CCC(O)CC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3945726	ChEMBL	8.7	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCN2CCCCC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3957950	ChEMBL	7.26	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCN2CCNCC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3985495	ChEMBL	6.17	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCNCCO)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL3940395	ChEMBL	6.19	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCNCCO)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3909500	ChEMBL	6.75	—	—	O=c1[nH]c(N2CCOCC2)nc(NCCc2ncc[nH]2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622523	ChEMBL	7.1	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111965	ChEMBL	6.33	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1cc2ccccc2cn1
E3 Binder	CHEMBL4114134	ChEMBL	6.29	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1ccc(C2CC2)cn1
E3 Binder	CHEMBL4108348	ChEMBL	7.58	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4114603	ChEMBL	6.73	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1cccc(-n2cccc2)n1
E3 Binder	CHEMBL4108981	ChEMBL	8.15	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-c2ccccc2)n1
E3 Binder	CHEMBL4109565	ChEMBL	7.92	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-n2cccc2)n1
E3 Binder	CHEMBL4108289	ChEMBL	7.09	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-n2cccn2)n1
E3 Binder	CHEMBL4111400	ChEMBL	8.4	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-n2ccnc2)n1
E3 Binder	CHEMBL4113174	ChEMBL	7.0	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2cc(F)cc(F)c2)cs1
E3 Binder	CHEMBL4109478	ChEMBL	7.05	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2cc(F)ccc2F)cs1
E3 Binder	CHEMBL4107260	ChEMBL	6.82	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccc(Cl)cc2)cs1
E3 Binder	CHEMBL4109278	ChEMBL	7.62	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL4114234	ChEMBL	6.85	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2cccc(C(F)(F)F)c2)cs1
E3 Binder	CHEMBL4108838	ChEMBL	7.4	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2cccc(F)c2)cs1
E3 Binder	CHEMBL4106984	ChEMBL	7.22	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccccc2F)cs1
E3 Binder	CHEMBL4112124	ChEMBL	7.68	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccccn2)cs1
E3 Binder	CHEMBL4107485	ChEMBL	6.36	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc(C2CC2)cs1
E3 Binder	CHEMBL4107471	ChEMBL	8.05	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2c(C3CC3)nccc2s1
E3 Binder	CHEMBL4112923	ChEMBL	7.72	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(Br)ccc2s1
E3 Binder	CHEMBL4112012	ChEMBL	7.16	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(C(F)(F)F)ccc2s1
E3 Binder	CHEMBL4112199	ChEMBL	6.48	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(C3CC3)ccc2s1
E3 Binder	CHEMBL4108791	ChEMBL	8.1	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(Cl)ccc2s1
E3 Binder	CHEMBL4111712	ChEMBL	8.08	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(F)ccc2s1
E3 Binder	CHEMBL4107194	ChEMBL	7.34	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccc(F)cc2s1
E3 Binder	CHEMBL4114583	ChEMBL	6.28	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cccc(C(F)(F)F)c2s1
E3 Binder	CHEMBL4114416	ChEMBL	6.75	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cccc(Cl)c2s1
E3 Binder	CHEMBL3622518	ChEMBL	7.72	4S3	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4109845	ChEMBL	7.92	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cnccc2s1
E3 Binder	CHEMBL4108414	ChEMBL	6.66	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1ncc(F)cn1
E3 Binder	CHEMBL3622528	ChEMBL	6.34	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCC[C@@H](O)C2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622520	ChEMBL	7.44	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112425	ChEMBL	6.72	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@@H]3CN[C@H]2C3)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4110461	ChEMBL	8.02	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4115519	ChEMBL	8.25	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL3621219	ChEMBL	7.96	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3898529	ChEMBL	6.59	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622519	ChEMBL	6.21	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@H]2CCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113113	ChEMBL	6.1	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@H]2CNCC(F)(F)C2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3353203	ChEMBL	7.85	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@H]2CNCC[C@@H]2F)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622525	ChEMBL	7.07	—	—	O=c1[nH]c(N2CCOCC2)nc(N[C@H]2CNC[C@H](O)C2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112526	ChEMBL	6.06	—	—	O=c1[nH]c(N2CCOCC2CO)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4115050	ChEMBL	7.89	—	—	O=c1[nH]c(N2CC[C@@H](CO)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4107909	ChEMBL	7.77	—	—	O=c1[nH]c(N2CC[C@@H](O)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3983208	ChEMBL	7.82	—	—	O=c1[nH]c(N2CC[C@H](CO)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL3892729	ChEMBL	7.89	—	—	O=c1[nH]c(N2CC[C@H](F)C2)nc(N[C@@H]2CCCNC2)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4107486	ChEMBL	7.64	—	—	O=c1[nH]c(N2CC[C@H](O)C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4106577	ChEMBL	7.24	—	—	O=c1[nH]c(N2CCc3ccccc3C2)nc(N[C@@H]2CCCNC2)c1-c1nc(-c2ccc(F)cc2)cs1
E3 Binder	CHEMBL3622516	ChEMBL	8.14	—	—	O=c1[nH]c(N2CCc3ccccc3C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111167	ChEMBL	7.58	—	—	O=c1[nH]c(N2CCc3cnccc3C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108601	ChEMBL	6.95	—	—	O=c1[nH]c(N2CCn3cc(C(F)(F)F)nc3C2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4113480	ChEMBL	6.49	—	—	O=c1[nH]c(NC2CC(F)(F)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3622183	ChEMBL	7.6	4S2	—	O=c1[nH]c(NC2CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114137	ChEMBL	7.72	—	—	O=c1[nH]c(NC2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccc2ccccc2n1
E3 Binder	CHEMBL4115438	ChEMBL	6.23	—	—	O=c1[nH]c(NC2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccccn1
E3 Binder	CHEMBL4109195	ChEMBL	7.7	—	—	O=c1[nH]c(NC2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107142	ChEMBL	8.6	—	—	O=c1[nH]c(NC2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2cnccc2s1
E3 Binder	CHEMBL4108381	ChEMBL	7.04	—	—	O=c1[nH]c(NC2CCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107413	ChEMBL	6.2	—	—	O=c1[nH]c(NC2CCCCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114035	ChEMBL	6.24	—	—	O=c1[nH]c(NC2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108483	ChEMBL	6.18	—	—	O=c1[nH]c(NC2CNC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4111171	ChEMBL	6.05	—	—	O=c1[nH]c(NC2COC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4112772	ChEMBL	6.35	—	—	O=c1[nH]c(NCCO)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108856	ChEMBL	6.55	—	—	O=c1[nH]c(Nc2ccc(F)cc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4108417	ChEMBL	6.49	—	—	O=c1[nH]c(Nc2ccccc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4114262	ChEMBL	6.18	—	—	O=c1[nH]c(Nc2ccncc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL4107000	ChEMBL	6.46	—	—	O=c1[nH]c(Nc2cncnc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
E3 Binder	CHEMBL3601194	ChEMBL	6.69	—	—	OC[C@H]1C[C@@H](Nc2cc(NC3CCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3622531	ChEMBL	6.33	—	—	OC[C@H]1C[C@@H](Nc2nc(NC3CC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601077	ChEMBL	6.19	—	—	OC[C@H]1C[C@@H](Nc2nc(NC3CC3)ncc2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601081	ChEMBL	7.75	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3cccnc3)ncc2-c2nc3ccncc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601074	ChEMBL	7.96	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3cccnc3)ncc2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601190	ChEMBL	7.36	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3ccnc(OC4CC4)c3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601188	ChEMBL	7.03	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3cncnc3)ncc2-c2nc(-c3ccccc3)cs2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601078	ChEMBL	8.22	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3cncnc3)ncc2-c2nc3ccncc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3601073	ChEMBL	7.92	—	—	OC[C@H]1C[C@@H](Nc2nc(Nc3cncnc3)ncc2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O
E3 Binder	CHEMBL3964003	ChEMBL	8.22	—	—	[C-]#[N+]C1(NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL3921909	ChEMBL	8.1	—	—	[C-]#[N+]CC(=O)N1CCC(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1
E3 Binder	CHEMBL403490	ChEMBL	6.31	—	—	c1cc(-c2cnc3ccccn23)nc(N2CCCNCC2)c1
E3 Binder	CHEMBL402080	ChEMBL	6.9	—	—	c1cc(-c2cnc3ccccn23)nc(N2C[C@H]3C[C@@H]2CN3)c1
E3 Binder	CHEMBL402344	ChEMBL	6.26	—	—	c1cc(NC2CCNC2)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL255867	ChEMBL	8.7	—	—	c1cc(NC2CCNCC2)nc(-c2cnc3ccc(-c4cc[nH]n4)cn23)c1
E3 Binder	CHEMBL255445	ChEMBL	7.2	—	—	c1cc(NC2CCNCC2)nc(-c2cnc3ccc(-c4ccc[nH]4)cn23)c1
E3 Binder	CHEMBL258004	ChEMBL	7.46	—	—	c1cc(NC2CCNCC2)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL500069	ChEMBL	6.34	—	—	c1cc(NC2CCNCC2)nc(-c2n[nH]c3ccccc23)c1
E3 Binder	CHEMBL255272	ChEMBL	7.16	—	—	c1cc(NC2CCNCC2)nc(-n2cnc3ccccc32)c1
E3 Binder	CHEMBL437208	ChEMBL	7.41	—	—	c1cc(NC2CNC2)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL402295	ChEMBL	6.65	—	—	c1cc(NC2C[C@H]3CC[C@@H](C2)N3)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL403395	ChEMBL	6.5	—	—	c1cc(NCC2CCCN2)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL256504	ChEMBL	7.72	—	—	c1cc(N[C@H]2CCCNC2)nc(-c2cnc3ccccn23)c1
E3 Binder	CHEMBL4104915	ChEMBL	7.66	—	—	c1cc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1
E3 Binder	CHEMBL255098	ChEMBL	6.67	—	—	c1ccn2c(-c3ccnc(NC4CCNCC4)n3)cnc2c1
E3 Binder	CHEMBL4094760	ChEMBL	6.24	—	—	c1nc(N[C@H]2CC[C@@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1
E3 Binder	CHEMBL4064608	ChEMBL	9.15	6R1	—	c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1
E3 Binder	CHEMBL4286802	ChEMBL	7.06	—	—	c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)ccn2n1
E3 Binder	CHEMBL4067302	ChEMBL	7.48	—	—	c1nc(O[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1
E3 Binder	CHEMBL4087063	ChEMBL	8.4	—	—	c1nc(S[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1