ASB6

Details:

UniProt Entry: Q9NWX5
Gene: ASB6
Class: Other E3 Components
Family: Receptor
Protein length: 421
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NWX5
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLERKA
HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE
LLVHHGADVN RRDRIHESSP LDLASEEPER LPCLQRLLDL GADVNAADKH GKTALLHALA
SSDGVQIHNT ENIRLLLEGG ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF
QVTRLLLAHG ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
HIIFERLCSH PGCTEDESHA DLLRKAETVL DLMVTNSQKL QLPENFDIHP VGSLAEKIQA
LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP LPDRLKWYLL SEHSGSVEDD
I

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
14	344	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
48	298	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	SSF48403
68	97	Repeat	Ankyrin repeat	IPR002110	SM00248
102	131	Repeat	Ankyrin repeat	IPR002110	SM00248
102	134	Repeat	Ankyrin repeat	IPR002110	PS50088
104	133	Repeat	Ankyrin repeat	IPR002110	PF00023
136	169	Repeat	Ankyrin repeat	IPR002110	PS50088
136	166	Repeat	Ankyrin repeat	IPR002110	SM00248
170	205	Repeat	Ankyrin repeat	IPR002110	SM00248
258	289	Repeat	Ankyrin repeat	IPR002110	SM00248
360	415	Domain	SOCS box domain	IPR001496	PS50225
365	413	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
366	413	Domain	SOCS box domain	IPR001496	SM00253
370	413	Domain	Ankyrin repeat and SOCS box protein 6, SOCS box domain	IPR037327	cd03725
372	410	Domain	SOCS box domain	IPR001496	PF07525
372	412	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:16325183

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.