FANCL

Details:

UniProt Entry: Q9NW38
Gene: FANCL
Class: RING
Family: RING1
Protein length: 375
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3zqs, 4ccg, 7kzp, 7kzq, 7kzr, 7kzs, 7kzt, 7kzv

Protein Sequence ▾

>Q9NW38
MAVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN ARLLCSWQLR
TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE LYALPPPPQF YSSLIEEIGT
LGWDKLVYAD TCFSTIKLKA EDASGREHLI TLKLKAKYPA ESPDYFVDFP VPFCASWTPQ
SSLISIYSQF LAAIESLKAF WDVMDEIDEK TWVLEPEKPP RSATARRIAL GNNVSINIEV
DPRHPTMLPE CFFLGADHVV KPLGIKLSRN IHLWDPENSV LQNLKDVLEI DFPARAILEK
SDFTMDCGIC YAYQLDGTIP DQVCDNSQCG QPFHQICLYE WLRGLLTSRQ SFNIIFGECP
YCSKPITLKM SGRKH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	92	Domain	Fanconi anemia complex, subunit FancL, WD-repeat containing domain	IPR019162	PF09765
8	372	Family	E3 ubiquitin-protein ligase FANCL	IPR026848	PTHR13206
108	197	Domain	FANCL, UBC-like domain 2	IPR043898	PF18890
109	196	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
197	291	Homologous_superfamily	FANCL, UBC-like domain 3 superfamily	IPR043003	G3DSA:3.10.110.20
200	294	Domain	FANCL, UBC-like domain 3	IPR044037	PF18891
292	375	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
303	371	Domain	FANCL C-terminal domain	IPR026850	PF11793

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0036297	interstrand cross-link repair	Biological Process	IEA	GO_REF:0000002
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007276	gamete generation	Biological Process	IEA	GO_REF:0000107
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043240	Fanconi anaemia nuclear complex	Cellular Component	IEA	GO_REF:0000002
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0000785	chromatin	Cellular Component	IDA	PMID:22343915
GO:0005635	nuclear envelope	Cellular Component	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-6785126
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9835411
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:24389026
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:16916645

Enzyme–Substrate Interactions ▾


Q9NVI1	FANCI	Yes	Yes	No	No	—	No	E3-specific

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