RNF12

>Q9NVW2
MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN NLLGTPGEST
EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID WLNSVRQTGN TTRSGQRGNQ
SWRAVSRTNP NSGDFRFSLE INVNRNNGSQ NSENENEPSA RRSSGENVEN NSQRQVENPR
SESTSARPSR SERNSTEALT EVPPTRGQRR ARSRSPDHRR TRARAERSRS PLHPMSEIPR
RSHHSISSQT FEHPLVNETE GSSRTRHHVT LRQQISGPEL LSRGLFAASG TRNASQGAGS
SDTAASGEST GSGQRPPTIV LDLQVRRVRP GEYRQRDSIA SRTRSRSQTP NNTVTYESER
GGFRRTFSRS ERAGVRTYVS TIRIPIRRIL NTGLSETTSV AIQTMLRQIM TGFGELSYFM
YSDSDSEPTG SVSNRNMERA ESRSGRGGSG GGSSSGSSSS SSSSSSSSSS SSSSSSPSSS
SGGESSETSS DLFEGSNEGS SSSGSSGARR EGRHRAPVTF DESGSLPFLS LAQFFLLNED
DDDQPRGLTK EQIDNLAMRS FGENDALKTC SVCITEYTEG NKLRKLPCSH EYHVHCIDRW
LSENSTCPIC RRAVLASGNR ESVV

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
535	616	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
569	611	Domain	Zinc finger, RING-type	IPR001841	PF13639
570	611	Domain	Zinc finger, RING-type	IPR001841	PS50089
570	610	Domain	Zinc finger, RING-type	IPR001841	SM00184

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	NAS	PMID:11013082
GO:0060816	random inactivation of X chromosome	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0017053	transcription repressor complex	Cellular Component	NAS	PMID:11013082
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0003714	transcription corepressor activity	Molecular Function	NAS	PMID:11013082
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96MM3	ZFP42	Yes	Yes	No	No	—	No	E3-specific
P25791	RBTN2	Yes	Yes	No	No	11882901	EBI-8165490	E3-specific
O43679	LDB2	Yes	Yes	Yes	No	11882901	EBI-8165418	E3-specific
Q9UBR4	LHX3	Yes	Yes	No	No	—	No	E3-specific
Q92994	TF3B	Yes	No	No	No	—	No	E3-specific
P54274	TERF1	Yes	Yes	No	No	—	No	E3-specific
P50458	LHX2	Yes	Yes	No	No	—	No	E3-specific
P16949	STMN1	Yes	Yes	No	No	—	No	E3-specific
P61968	LMO4	Yes	Yes	No	No	—	No	E3-specific
Q9NVW2	RNF12	Yes	Yes	No	No	—	No	E3-specific