KLH11

Details:

UniProt Entry: Q9NVR0
Gene: KLHL11
Class: Other E3 Components
Family: Adaptor
Protein length: 708
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NVR0
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP GPGISAMEAS
GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF GGAGGREFRA HRSVLAAATE
YFTPLLSGQF SESRSGRVEM RKWSSEPGPE PDTVEAVIEY MYTGRIRVST GSVHEVLELA
DRFLLIRLKE FCGEFLKKKL HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE
FYTLPFHLIR DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL LPRYGQNMDV
IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH AVAVTESYVY VAGSMEPGFA
KTVERYNPNL NTWEHVCSLM TRKHSFGLTE VKGKLYSIGG HGNFSPGFKD VTVYNPELDK
WHNLESAPKI LRDVKALAIE DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL
PLIDNYCFFQ MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP RCRATACHVR
IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR VPSSQIEC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
72	198	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
76	225	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
85	199	Domain	BTB/POZ domain	IPR000210	PF00651
94	170	Domain	BTB/POZ domain	IPR000210	PS50097
94	200	Domain	BTB/POZ domain	IPR000210	SM00225
205	307	Domain	BTB/Kelch-associated	IPR011705	SM00875
205	307	Domain	BTB/Kelch-associated	IPR011705	PF07707
332	541	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
359	561	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
360	407	Repeat	Kelch repeat type 1	IPR006652	SM00612
408	453	Repeat	Kelch repeat type 1	IPR006652	SM00612
445	486	Repeat	Kelch repeat type 1	IPR006652	PF01344
454	501	Repeat	Kelch repeat type 1	IPR006652	SM00612
581	671	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
593	659	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
610	661	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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