ZBT40

Details:

UniProt Entry: Q9NUA8
Gene: ZBTB40
Class: RING
Family: RING6
Protein length: 1239
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9NUA8
MELPNYSRQL LQQLYTLCKE QQFCDCTISI GTIYFRAHKL VLAAASLLFK TLLDNTDTIS
IDASVVSPEE FALLLEMMYT GKLPVGKHNF SKIISLADSL QMFDVAVSCK NLLTSLVNCS
VQGQVVRDVS APSSETFRKE PEKPQVEILS SEGAGEPHSS PELAATPGGP VKAETEEAAH
SVSQEMSVNS PTAQESQRNA ETPAETPTTA EACSPSPAVQ TFSEAKKTST EPGCERKHYQ
LNFLLENEGV FSDALMVTQD VLKKLEMCSE IKGPQKEMIV KCFEGEGGHS AFQRILGKVR
EESLDVQTVV SLLRLYQYSN PAVKTALLDR KPEDVDTVQP KGSTEEGKTL SVLLLEHKED
LIQCVTQLRP IMESLETAKE EFLTGTEKRV ILNCCEGRTP KETIENLLHR MTEEKTLTAE
GLVKLLQAVK TTFPNLGLLL EKLQKSATLP STTVQPSPDD YGTELLRRYH ENLSEIFTDN
QILLKMISHM TSLAPGEREV MEKLVKRDSG SGGFNSLISA VLEKQTLSAT AIWQLLLVVQ
ETKTCPLDLL MEEIRREPGA DAFFRAVTTP EHATLETILR HNQLILEAIQ QKIEYKLFTS
EEEHLAETVK EILSIPSETA SPEASLRAVL SRAMEKSVPA IEICHLLCSV HKSFPGLQPV
MQELAYIGVL TKEDGEKETW KVSNKFHLEA NNKEDEKAAK EDSQPGEQND QGETGSLPGQ
QEKEASASPD PAKKSFICKA CDKSFHFYCR LKVHMKRCRV AKSKQVQCKE CSETKDSKKE
LDKHQLEAHG AGGEPDAPKK KKKRLPVTCD LCGREFAHAS GMQYHKLTEH FDEKPFSCEE
CGAKFAANST LKNHLRLHTG DRPFMCKHCL MTFTQASALA YHTKKKHSEG KMYACQYCDA
VFAQSIELSR HVRTHTGDKP YVCRDCGKGF RQANGLSIHL HTFHNIEDPY DCKKCRMSFP
TLQDHRKHIH EVHSKEYHPC PTCGKIFSAP SMLERHVVTH VGGKPFSCGI CNKAYQQLSG
LWYHNRTHHP DVFAAQNHRS SKFSSLQCSS CDKTFPNTIE HKKHIKAEHA DMKFHECDQC
KELFPTPALL QVHVKCQHSG SQPFRCLYCA ATFRFPGALQ HHVTTEHFKQ SETTFPCELC
GELFTSQAQL DSHLESEHPK VMSTETQAAA SQMAQVIQTP EPVAPTEQVI TLEETQLAGS
QVFVTLPDSQ ASQASSELVA VTVEDLLDGT VTLICGEAK

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	130	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
2	114	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
17	114	Domain	BTB/POZ domain	IPR000210	PF00651
24	117	Domain	BTB/POZ domain	IPR000210	SM00225
24	87	Domain	BTB/POZ domain	IPR000210	PS50097
736	756	Domain	Zinc finger C2H2-type	IPR013087	SM00355
766	789	Domain	Zinc finger C2H2-type	IPR013087	SM00355
806	839	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
807	830	Domain	Zinc finger C2H2-type	IPR013087	SM00355
807	835	Domain	Zinc finger C2H2-type	IPR013087	PS50157
809	830	Domain	Zinc finger C2H2-type	IPR013087	PS00028
830	882	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
836	863	Domain	Zinc finger C2H2-type	IPR013087	PS50157
836	858	Domain	Zinc finger C2H2-type	IPR013087	PF00096
836	858	Domain	Zinc finger C2H2-type	IPR013087	SM00355
838	858	Domain	Zinc finger C2H2-type	IPR013087	PS00028
864	892	Domain	Zinc finger C2H2-type	IPR013087	PS50157
864	887	Domain	Zinc finger C2H2-type	IPR013087	SM00355
866	887	Domain	Zinc finger C2H2-type	IPR013087	PS00028
887	939	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
893	915	Domain	Zinc finger C2H2-type	IPR013087	PF00096
893	920	Domain	Zinc finger C2H2-type	IPR013087	PS50157
893	915	Domain	Zinc finger C2H2-type	IPR013087	SM00355
895	915	Domain	Zinc finger C2H2-type	IPR013087	PS00028
921	944	Domain	Zinc finger C2H2-type	IPR013087	PF00096
921	944	Domain	Zinc finger C2H2-type	IPR013087	SM00355
921	949	Domain	Zinc finger C2H2-type	IPR013087	PS50157
923	944	Domain	Zinc finger C2H2-type	IPR013087	PS00028
950	973	Domain	Zinc finger C2H2-type	IPR013087	SM00355
950	978	Domain	Zinc finger C2H2-type	IPR013087	PS50157
952	973	Domain	Zinc finger C2H2-type	IPR013087	PS00028
977	1028	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
978	1000	Domain	Zinc finger C2H2-type	IPR013087	PF00096
978	1000	Domain	Zinc finger C2H2-type	IPR013087	SM00355
978	1005	Domain	Zinc finger C2H2-type	IPR013087	PS50157
980	1000	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1006	1028	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1006	1028	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1046	1074	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1046	1069	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1048	1069	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1069	1122	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
1075	1103	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1075	1098	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1077	1098	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1104	1127	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1135	1158	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1135	1158	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1137	1158	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006974	DNA damage response	Biological Process	IDA	PMID:17525332
GO:0030282	bone mineralization	Biological Process	NAS	PMID:20554715
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:28169274

Enzyme–Substrate Interactions ▾

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