RN146

Details:

UniProt Entry: Q9NTX7
Gene: RNF146
Class: RING
Family: RING4
Protein length: 359
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2d8t, 3v3l, 6cf6

Protein Sequence ▾

>Q9NTX7
MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC
VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER
TSRELEDAFS KGKKNTEMLI AGFLYVADLE NMVQYRRNEH GRRRKIKRDI IDIPKKGVAG
LRLDCDANTV NLARESSADG ADSVSAQSGA SVQPLVSSVR PLTSVDGQLT SPATPSPDAS
TSLEDSFAHL QLSGDNTAER SHRGEGEEDH ESPSSGRVPA PDTSIEETES DASSDSEDVS
AVVAQHSLTQ QRLLVSNANQ TVPDRSDRSG TDRSVAGGGT VSVSVRSRRP DGQCTVTEV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	104	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
21	193	Family	E3 ubiquitin-protein ligase RNF146	IPR033509	PTHR13417
36	75	Domain	RNF146, RING finger, HC subclass	IPR044110	cd16546
37	74	Domain	Zinc finger, RING-type	IPR001841	SM00184
37	75	Domain	Zinc finger, RING-type	IPR001841	PS50089
52	61	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
76	182	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
92	168	Domain	WWE domain	IPR004170	PS50918
101	176	Domain	WWE domain, subgroup	IPR018123	SM00678
104	168	Domain	WWE domain	IPR004170	PF02825
105	184	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:21478859
GO:0070936	protein K48-linked ubiquitination	Biological Process	IMP	PMID:21478859
GO:0090263	positive regulation of canonical Wnt signaling pathway	Biological Process	IMP	PMID:21478859
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:21478859
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0072572	poly-ADP-D-ribose binding	Molecular Function	IEA	GO_REF:0000002

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q7L8J4	3BP5L	Yes	No	No	No	—	No	E3-specific
O15234	CASC3	Yes	Yes	No	No	—	No	E3-specific
Q9H2G9	GO45	Yes	Yes	No	No	—	No	E3-specific
O95271	TNKS1	Yes	Yes	Yes	No	21799911, 25327252	EBI-16124474	E3-specific
P18887	XRCC1	Yes	Yes	No	No	21799911	EBI-22117202	E3-specific
Q9H2K2	TNKS2	Yes	Yes	No	No	21799911	EBI-22117309	E3-specific
O60239	3BP5	Yes	No	No	No	—	No	E3-specific
Q9Y2T1	AXIN2	Yes	Yes	No	No	—	No	E3-specific

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