CISH

Details:

UniProt Entry: Q9NSE2
Gene: CISH
Class: Other E3 Components
Family: Receptor
Protein length: 258
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NSE2
MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV
KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP
TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC
LPLPRRMADY LRQYPFQL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
67	215	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
71	166	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
77	164	Domain	CIS, SH2 domain	IPR035887	cd10718
80	169	Domain	SH2 domain	IPR000980	SM00252
82	96	Domain	SH2 domain	IPR000980	PR00401
82	163	Domain	SH2 domain	IPR000980	PF00017
82	188	Domain	SH2 domain	IPR000980	PS50001
101	111	Domain	SH2 domain	IPR000980	PR00401
152	166	Domain	SH2 domain	IPR000980	PR00401
209	257	Domain	SOCS box domain	IPR001496	PS50225
210	257	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
214	255	Domain	SOCS box domain	IPR001496	SM00253
220	254	Domain	SOCS box domain	IPR001496	SM00969
221	251	Domain	SOCS box domain	IPR001496	PF07525

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001960	negative regulation of cytokine-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0001558	regulation of cell growth	Biological Process	NAS	PMID:9465889
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Biological Process	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952039
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005126	cytokine receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16273093

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