TOPRS

Details:

UniProt Entry: Q9NS56
Gene: TOPORS
Class: RING
Family: RING9
Protein length: 1045
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9NS56
MGSQPPLGSP LSREEGEAPP PAPASEGRRR SRRVRLRGSC RHRPSFLGCR ELAASAPARP
APASSEIMAS AAKEFKMDNF SPKAGTSKLQ QTVPADASPD SKCPICLDRF DNVSYLDRCL
HKFCFRCVQE WSKNKAECPL CKQPFDSIFH SVRAEDDFKE YVLRPSYNGS FVTPDRRFRY
RTTLTRERNA SVYSPSGPVN RRTTTPPDSG VLFEGLGIST RPRDVEIPQF MRQIAVRRPT
TADERSLRKI QEQDIINFRR TLYRAGARVR NIEDGGRYRD ISAEFFRRNP ACLHRLVPWL
KRELTVLFGA HGSLVNIVQH IIMSNVTRYD LESQAFVSDL RPFLLNRTEH FIHEFISFAR
SPFNMAAFDQ HANYDCPAPS YEEGSHSDSS VITISPDEAE TQELDINVAT VSQAPWDDET
PGPSYSSSEQ VHVTMSSLLN TSDSSDEELV TGGATSQIQG VQTNDDLNND SDDSSDNCVI
VGFVKPLAER TPELVELSSD SEDLGSYEKM ETVKTQEQEQ SYSSGDSDVS RCSSPHSVLG
KDEQINKGHC DSSTRIKSKK EEKRSTSLSS PRNLNSSVRG DRVYSPYNHR HRKRGRSRSS
DSRSQSRSGH DQKNHRKHHG KKRMKSKRSR SRESSRPRGR RDKKRSRTRD SSWSRRSQTL
SLSSESTSRS RSRSSDHGKR RSRSRNRDRY YLRNNYGSRY KWEYTYYSRN KDRDGYESSY
RRRTLSRAHY SRQSSSPEFR VQSFSERTNA RKKNNHSERK YYYYERHRSR SLSSNRSRTA
STGTDRVRNE KPGGKRKYKT RHLEGTNEVA QPSREFASKA KDSHYQKSSS KLDGNYKNES
DTFSDSRSSD RETKHKRRKR KTRSLSVEIV YEGKATDTTK HHKKKKKKHK KKHKKHHGDN
ASRSPVVITI DSDSDKDSEV KEDTECDNSG PQDPLQNEFL APSLEPFETK DVVTIEAEFG
VLDKECDIAT LSNNLNNANK TVDNIPPLAA SVEQTLDVRE ESTFVSDLEN QPSNIVSLQT
EPSRQLPSPR TSLMSVCLGR DCDMS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
97	163	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
103	142	Domain	Zinc finger, RING-type	IPR001841	PS50089
103	141	Domain	Zinc finger, RING-type	IPR001841	SM00184
119	128	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006351	DNA-templated transcription	Biological Process	NAS	PMID:10352183
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:19473992
GO:0006513	protein monoubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000120
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Biological Process	IEA	GO_REF:0000117
GO:0010842	retina layer formation	Biological Process	ISS	PMID:21159800
GO:0016925	protein sumoylation	Biological Process	IBA	GO_REF:0000033
GO:0034504	protein localization to nucleus	Biological Process	IMP	PMID:20188669
GO:0035845	photoreceptor cell outer segment organization	Biological Process	ISS	PMID:21159800
GO:0043066	negative regulation of apoptotic process	Biological Process	ISS	PMID:21159800
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:18077445
GO:0051457	maintenance of protein location in nucleus	Biological Process	IDA	PMID:14516784
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:15247280
GO:0016605	PML body	Cellular Component	IDA	PMID:21159800
GO:0016607	nuclear speck	Cellular Component	IBA	GO_REF:0000033
GO:0032391	photoreceptor connecting cilium	Cellular Component	IBA	GO_REF:0000033
GO:0036064	ciliary basal body	Cellular Component	IBA	GO_REF:0000033
GO:0000922	spindle pole	Cellular Component	IDA	PMID:21159800
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005814	centriole	Cellular Component	IDA	PMID:21159800
GO:0030496	midbody	Cellular Component	TAS	PMID:21159800
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:15247280
GO:0000930	gamma-tubulin complex	Cellular Component	IDA	PMID:21159800
GO:0003677	DNA binding	Molecular Function	IDA	PMID:11278651
GO:0003823	antigen binding	Molecular Function	IPI	PMID:10415337
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:18077445
GO:0005515	protein binding	Molecular Function	IPI	PMID:11842245
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019789	SUMO transferase activity	Molecular Function	EXP	PMID:17803295
GO:0044547	DNA topoisomerase binding	Molecular Function	IPI	PMID:10352183
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q99801	NKX31	Yes	Yes	No	No	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.