I17RB

Details:

UniProt Entry: Q9NRM6
Gene: IL17RB
Class: RING
Family: RING1
Protein length: 502
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 7uwj, 7uwk, 7uwl

Protein Sequence ▾

>Q9NRM6
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG
DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT
FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW
DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT
GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR
SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ
DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL
HVKQQVSAGK RSQACHDGCC SL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
6	175	Homologous_superfamily	Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily	IPR038683	G3DSA:2.60.40.2160
6	493	Family	Interleukin-17 receptor-like	IPR039465	PTHR15583
33	175	Domain	Interleukin-17 receptor, fibronectin-III-like domain 1	IPR032356	PF16556
176	270	Homologous_superfamily	Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily	IPR043046	G3DSA:2.60.40.2150
331	477	Domain	SEFIR domain	IPR013568	PS51534
333	479	Domain	SEFIR domain	IPR013568	PF08357

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IEA	GO_REF:0000108
GO:0032736	positive regulation of interleukin-13 production	Biological Process	IEA	GO_REF:0000107
GO:0032754	positive regulation of interleukin-5 production	Biological Process	IEA	GO_REF:0000107
GO:0050729	positive regulation of inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0001558	regulation of cell growth	Biological Process	NAS	PMID:10815801
GO:0006952	defense response	Biological Process	TAS	PMID:10749887
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005576	extracellular region	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0009986	cell surface	Cellular Component	IEA	GO_REF:0000107
GO:0030368	interleukin-17 receptor activity	Molecular Function	IEA	GO_REF:0000002
GO:0004896	cytokine receptor activity	Molecular Function	NAS	PMID:10815801
GO:0005515	protein binding	Molecular Function	IPI	PMID:22070932

Enzyme–Substrate Interactions ▾


O00628	PEX7	Yes	No	No	No	—	No	E3-specific

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