BAZ1A

Details:

UniProt Entry: Q9NRL2
Gene: BAZ1A
Class: RING
Family: RING10
Protein length: 1556
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 5uiy

Protein Sequence ▾

>Q9NRL2
MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL VWSCAVTGRP
GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR LHEICDDIFA YVKDRYFVEE
TVEVIRNNGA RLQCRILEVL PPSHQNGFAN GHVNSVDGET IIISDSDDSE TQSCSFQNGK
KKDAIDPLLF KYKVQPTKKE LHESAIVKAT QISRRKHLFS RDKLKLFLKQ HCEPQDGVIK
IKASSLSTYK IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRIHISQEDN VANKQTLASY
RSKATKERDK LLKQEEMKSL AFEKAKLKRE KADALEAKKK EKEDKEKKRE ELKKIVEEER
LKKKEEKERL KVEREKEREK LREEKRKYVE YLKQWSKPRE DMECDDLKEL PEPTPVKTRL
PPEIFGDALM VLEFLNAFGE LFDLQDEFPD GVTLEVLEEA LVGNDSEGPL CELLFFFLTA
IFQAIAEEEE EVAKEQLTDA DTKDLTEALD EDADPTKSAL SAVASLAAAW PQLHQGCSLK
SLDLDSCTLS EILRLHILAS GADVTSANAK YRYQKRGGFD ATDDACMELR LSNPSLVKKL
SSTSVYDLTP GEKMKILHAL CGKLLTLVST RDFIEDYVDI LRQAKQEFRE LKAEQHRKER
EEAAARIRKR KEEKLKEQEQ KMKEKQEKLK EDEQRNSTAD ISIGEEERED FDTSIESKDT
EQKELDQDMV TEDEDDPGSH KRGRRGKRGQ NGFKEFTRQE QINCVTREPL TADEEEALKQ
EHQRKEKELL EKIQSAIACT NIFPLGRDRM YRRYWIFPSI PGLFIEEDYS GLTEDMLLPR
PSSFQNNVQS QDPQVSTKTG EPLMSESTSN IDQGPRDHSV QLPKPVHKPN RWCFYSSCEQ
LDQLIEALNS RGHRESALKE TLLQEKSRIC AQLARFSEEK FHFSDKPQPD SKPTYSRGRS
SNAYDPSQMC AEKQLELRLR DFLLDIEDRI YQGTLGAIKV TDRHIWRSAL ESGRYELLSE
ENKENGIIKT VNEDVEEMEI DEQTKVIVKD RLLGIKTETP STVSTNASTP QSVSSVVHYL
AMALFQIEQG IERRFLKAPL DASDSGRSYK TVLDRWRESL LSSASLSQVF LHLSTLDRSV
IWSKSILNAR CKICRKKGDA ENMVLCDGCD RGHHTYCVRP KLKTVPEGDW FCPECRPKQR
SRRLSSRQRP SLESDEDVED SMGGEDDEVD GDEEEGQSEE EEYEVEQDED DSQEEEEVSL
PKRGRPQVRL PVKTRGKLSS SFSSRGQQQE PGRYPSRSQQ STPKTTVSSK TGRSLRKINS
APPTETKSLR IASRSTRHSH GPLQADVFVE LLSPRRKRRG RKSANNTPEN SPNFPNFRVI
ATKSSEQSRS VNIASKLSLQ ESESKRRCRK RQSPEPSPVT LGRRSSGRQG GVHELSAFEQ
LVVELVRHDD SWPFLKLVSK IQVPDYYDII KKPIALNIIR EKVNKCEYKL ASEFIDDIEL
MFSNCFEYNP RNTSEAKAGT RLQAFFHIQA QKLGLHVTPS NVDQVSTPPA AKKSRI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
22	128	Domain	WSTF/Acf1/Cbp146	IPR013136	PS51136
23	122	Domain	WSTF/Acf1/Cbp146	IPR013136	PF10537
422	487	Domain	DDT domain	IPR018501	PS50827
422	487	Domain	DDT domain	IPR018501	SM00571
424	483	Domain	DDT domain	IPR018501	PF02791
591	635	Domain	WHIM1 domain	IPR028942	PF15612
800	926	Domain	WHIM2 domain	IPR028941	PF15613
1117	1210	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1135	1201	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1148	1198	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
1150	1196	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1150	1197	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
1151	1195	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
1413	1532	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
1423	1535	Domain	Bromodomain adjacent to zinc finger domain protein 1A, bromodomain	IPR037325	cd05504
1424	1538	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
1427	1535	Domain	Bromodomain	IPR001487	SM00297
1439	1519	Domain	Bromodomain	IPR001487	PF00439
1446	1516	Domain	Bromodomain	IPR001487	PS50014
1449	1462	Domain	Bromodomain	IPR001487	PR00503
1451	1508	Conserved_site	Bromodomain, conserved site	IPR018359	PS00633
1463	1479	Domain	Bromodomain	IPR001487	PR00503
1479	1497	Domain	Bromodomain	IPR001487	PR00503
1497	1516	Domain	Bromodomain	IPR001487	PR00503

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000002
GO:0006261	DNA-templated DNA replication	Biological Process	IDA	PMID:12434153
GO:0006275	regulation of DNA replication	Biological Process	IMP	PMID:12434153
GO:0006334	nucleosome assembly	Biological Process	IDA	PMID:14759371
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	NAS	PMID:10662543
GO:0031445	regulation of heterochromatin formation	Biological Process	IBA	GO_REF:0000033
GO:0045740	positive regulation of DNA replication	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000228	nuclear chromosome	Cellular Component	IBA	GO_REF:0000033
GO:0005721	pericentric heterochromatin	Cellular Component	ISO	GO_REF:0000114
GO:0008623	CHRAC	Cellular Component	IBA	GO_REF:0000033
GO:0016590	ACF complex	Cellular Component	IPI	PMID:10655480
GO:0004402	histone acetyltransferase activity	Molecular Function	TAS	PMID:10662543
GO:0003677	DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:10655480
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4783401	ChEMBL	6.28	—	—	O=C(Nc1cccc([N+](=O)[O-])c1)Nc1nc(-c2ccccc2)cs1

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