FBX6

Details:

UniProt Entry: Q9NRD1
Gene: FBXO6
Class: Other E3 Components
Family: Receptor
Protein length: 293
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NRD1
MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL MTLWKRKCLR
EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA WQIDFNGGDR WKVESLPGAH
GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA EGYWEELLDT FRPDIVVKDW FAARADCGCT
YQLKVQLASA DYFVLASFEP PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ
YWAGWYGPRV TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	262	Family	F-box only protein	IPR039752	PTHR12125
10	92	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
10	57	Domain	F-box domain	IPR001810	PS50181
13	60	Domain	F-box domain	IPR001810	PF12937
16	57	Domain	F-box domain	IPR001810	SM00256
75	258	Homologous_superfamily	Galactose-binding-like domain superfamily	IPR008979	SSF49785
75	259	Domain	F-box associated (FBA) domain	IPR007397	SM01198
78	259	Domain	F-box associated (FBA) domain	IPR007397	PS51114
79	257	Domain	F-box associated (FBA) domain	IPR007397	PF04300

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006516	glycoprotein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0000077	DNA damage checkpoint signaling	Biological Process	TAS	PMID:19716789
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006508	proteolysis	Biological Process	TAS	PMID:10531035
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0006986	response to unfolded protein	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0036503	ERAD pathway	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	ISS	GO_REF:0000024
GO:0030246	carbohydrate binding	Molecular Function	IEA	GO_REF:0000107

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