KLHL1

Details:

UniProt Entry: Q9NR64
Gene: KLHL1
Class: Other E3 Components
Family: Adaptor
Protein length: 748
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9NR64
MSGSGRKDFD VKHILRLRWK LFSHPSPSTG GPAGGGCLQQ DGSGSFEHWG PSQSRLLKSQ
ERSGVSTFWK KPSSSSSSSS SPSSSSSSFN PLNGTLLPVA TRLQQGAPGQ GTQQPARTLF
YVESLEEEVV PGMDFPGPHE KGLVLQELKV EPDNSSQATG EGCGHRLSST GHSMTPQSDL
DSSSSEEFYQ AVHHAEQTFR KMESYLKQQQ LCDVILIVGN RKIPAHRLVL SSVSDYFAAM
FTSDVCEAKQ EEIKMEGIDP NALWDLVQFA YTGCLELKED TIENLLAAAC LLQLPQVVEV
CCHFLMKLLH PSNCLGIRAF ADAQGCIELM KVAHSYTMEN IMEVIRNQEF LLLPAEELHK
LLASDDVNVP DEETIFHALM MWVKYDMQSR CNDLSMLLAF IRLPLLPPQI LADLENHALF
KNDLECQKLI LEAMKYHLLP ERRTLMQSPR TKPRKSTVGT LYAVGGMDNN KGATTIEKYD
LRTNLWIQAG MMNGRRLQFG VAVIDDKLFV IGGRDGLKTL NTVECYNPKT KTWTVLPPMS
THRHGLGVTV LEGPIYAVGG HDGWSYLNTV ERWDPQSQQW TFVASMSIAR STVGVAALNG
KLYSVGGRDG SSCLSSMEYY DPHTNKWNMC APMCKRRGGV GVATCDGFLY AVGGHDAPAS
NHCSRLLDYV ERYDPKTDTW TMVAPLSMPR DAVGVCLLGD RLYAVGGYDG QTYLNTMESY
DPQTNEWTQM ASLNIGRAGA CVVVIKQP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
180	310	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
193	307	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
203	306	Domain	BTB/POZ domain	IPR000210	PF00651
212	309	Domain	BTB/POZ domain	IPR000210	SM00225
212	279	Domain	BTB/POZ domain	IPR000210	PS50097
314	413	Domain	BTB/Kelch-associated	IPR011705	PF07707
314	415	Domain	BTB/Kelch-associated	IPR011705	SM00875
439	632	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
459	489	Repeat	Kelch repeat type 1	IPR006652	PF01344
460	506	Repeat	Kelch repeat type 1	IPR006652	SM00612
460	658	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
495	540	Repeat	Kelch repeat type 1	IPR006652	PF01344
507	553	Repeat	Kelch repeat type 1	IPR006652	SM00612
543	587	Repeat	Kelch repeat type 1	IPR006652	PF01344
554	600	Repeat	Kelch repeat type 1	IPR006652	SM00612
589	633	Repeat	Kelch repeat type 1	IPR006652	PF01344
601	647	Repeat	Kelch repeat type 1	IPR006652	SM00612
631	745	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
633	747	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
636	687	Repeat	Kelch repeat type 1	IPR006652	PF01344
648	700	Repeat	Kelch repeat type 1	IPR006652	SM00612
690	734	Repeat	Kelch repeat type 1	IPR006652	PF01344
701	747	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007626	locomotory behavior	Biological Process	IEA	GO_REF:0000107
GO:0007628	adult walking behavior	Biological Process	IEA	GO_REF:0000107
GO:0016358	dendrite development	Biological Process	IEA	GO_REF:0000107
GO:0021680	cerebellar Purkinje cell layer development	Biological Process	IEA	GO_REF:0000107
GO:0030036	actin cytoskeleton organization	Biological Process	NAS	PMID:10888605
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0030425	dendrite	Cellular Component	IBA	GO_REF:0000033
GO:0043025	neuronal cell body	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:22632832
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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