JADE2

Details:

UniProt Entry: Q9NQC1
Gene: JADE2
Class: RING
Family: RING7
Protein length: 790
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9NQC1
MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS EVFRTDLITA
MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE PVVRILPPLE GPPAQASPSS
TMLGEGSQPD WPGGSRYDLD EIDAYWLELI NSELKEMERP ELDELTLERV LEELETLCHQ
NMARAIETQE GLGIEYDEDV VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS
WLCRTCALGV QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS
HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA DNDEVKFKSF
CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL EEDFYELVEP AEVAERLDLA
EALVDFIYQY WKLKRKANAN QPLLTPKTDE VDNLAQQEQD VLYRRLKLFT HLRQDLERVR
NLCYMVTRRE RTKHAICKLQ EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI
TAENMAMSEW PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL
PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR TSSHLPSSPA
AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA SPKPLGRLRP PRESKVTRRL
PGARPDAGMG PPSAVAERPK VSLHFDTETD GYFSDGEMSD SDVEAEDGGV QRGPREAGAE
EVVRMGVLAS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
14	175	Domain	Enhancer of polycomb-like, N-terminal	IPR019542	PF10513
189	249	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
192	261	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
199	249	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
201	247	Domain	Zinc finger, PHD-type	IPR001965	SM00249
201	246	Domain	JADE2, PHD domain	IPR039548	cd15680
202	246	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
250	367	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
251	365	Domain	Extended PHD (ePHD) domain	IPR034732	PS51805
254	364	Domain	JADE2, ePHD domain	IPR039549	cd15705
310	365	Domain	Zinc finger, PHD-type	IPR001965	SM00249

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006275	regulation of DNA replication	Biological Process	IEA	GO_REF:0000117
GO:0051726	regulation of cell cycle	Biological Process	IEA	GO_REF:0000117
GO:2000278	regulation of DNA biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0050767	regulation of neurogenesis	Biological Process	IEA	GO_REF:0000107
GO:0050769	positive regulation of neurogenesis	Biological Process	IEA	GO_REF:0000107
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:1990138	neuron projection extension	Biological Process	IEA	GO_REF:0000107
GO:0001558	regulation of cell growth	Biological Process	ISS	GO_REF:0000114
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000120
GO:0006355	regulation of DNA-templated transcription	Biological Process	ISS	GO_REF:0000114
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0000123	histone acetyltransferase complex	Cellular Component	IEA	GO_REF:0000117
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107
GO:0046972	histone H4K16 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0036408	histone H3K14 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043995	histone H4K5 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043996	histone H4K8 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043997	histone H4K12 acetyltransferase activity	Molecular Function	IDA	PMID:16387653

Enzyme–Substrate Interactions ▾

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