TRI36

Details:

UniProt Entry: Q9NQ86
Gene: TRIM36
Class: RING
Family: RING8
Protein length: 728
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 7qs4

Protein Sequence ▾

>Q9NQ86
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL
LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH
DVDLGERGIN GLFRNFTLET IVERYRQAAR AATAIMCDLC KPPPQESTKS CMDCSASYCN
ECFKIHHPWG TIKAQHEYVG PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN
HANHRVTTMS SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI
THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG YAQEVLKETD
QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT SKQTELLGEL SFFSSGIDVP
EINEEQSKVY NNALINWHHP EKDKADSYVL EYRKINRDDE MSWNEIEVCG TSKIIQDLEN
SSTYAFRVRA YKGSICSPCS RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR
AGFNLLLAAE RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW
LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT SSNEPENRVL
PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY PAFALMGSGG IQLEEPITAK
YLEYQEDM

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
15	129	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
28	125	Domain	E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass	IPR027726	cd16756
33	118	Domain	Zinc finger, RING-type	IPR001841	SM00184
33	63	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
33	84	Domain	Zinc finger, RING-type	IPR001841	PS50089
48	57	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
151	205	Domain	E3 ubiquitin-protein ligase Trim36, B-box-type 1 zinc finger	IPR047066	cd19848
207	249	Domain	B-box-type zinc finger	IPR000315	SM00336
207	249	Domain	B-box-type zinc finger	IPR000315	PS50119
210	254	Domain	E3 ubiquitin-protein ligase Trim36, B-box-type 2 zinc finger	IPR047065	cd19778
211	248	Domain	B-box-type zinc finger	IPR000315	PF00643
356	413	Domain	COS domain	IPR017903	PS51262
359	407	Domain	Midline-1, COS domain	IPR040859	PF18568
419	510	Domain	Fibronectin type III	IPR003961	PS50853
420	509	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
431	511	Homologous_superfamily	Fibronectin type III superfamily	IPR036116	SSF49265
431	497	Domain	Fibronectin type III	IPR003961	PF00041
431	498	Domain	Fibronectin type III	IPR003961	cd00063
495	720	Domain	B30.2/SPRY domain	IPR001870	PS50188
508	709	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
515	718	Domain	TRIM36, PRY/SPRY domain	IPR035727	cd12894
527	714	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
556	580	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
657	681	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007340	acrosome reaction	Biological Process	IEA	GO_REF:0000107
GO:0000281	mitotic cytokinesis	Biological Process	IMP	PMID:28087737
GO:0007051	spindle organization	Biological Process	IBA	GO_REF:0000033
GO:0051726	regulation of cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0070507	regulation of microtubule cytoskeleton organization	Biological Process	IMP	PMID:28087737
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0030133	transport vesicle	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0001669	acrosomal vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043014	alpha-tubulin binding	Molecular Function	ISS	GO_REF:0000024
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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