TRI39

Details:

UniProt Entry: Q9HCM9
Gene: TRIM39
Class: RING
Family: RING5
Protein length: 518
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2did, 2dif, 2ecj

Protein Sequence ▾

>Q9HCM9
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE
DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG
ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL
AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK
FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL
TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI
YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	89	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
29	70	Domain	Zinc finger, RING-type	IPR001841	PS50089
29	69	Domain	Zinc finger, RING-type	IPR001841	SM00184
44	53	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
102	143	Domain	B-box-type zinc finger	IPR000315	PS50119
102	143	Domain	B-box-type zinc finger	IPR000315	SM00336
103	143	Domain	B-box-type zinc finger	IPR000315	PF00643
319	514	Domain	B30.2/SPRY domain	IPR001870	PS50188
329	514	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
330	517	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
335	513	Domain	TRIM39, PRY/SPRY domain	IPR035033	cd13745
335	352	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
336	389	Domain	SPRY-associated	IPR006574	SM00589
339	388	Domain	SPRY-associated	IPR006574	PF13765
352	369	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
375	399	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
390	515	Domain	SPRY domain	IPR003877	SM00449
392	498	Domain	SPRY domain	IPR003877	PF00622
405	418	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
449	473	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
479	497	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007095	mitotic G2 DNA damage checkpoint signaling	Biological Process	IMP	PMID:23213251
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IMP	PMID:26363554
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0050821	protein stabilization	Biological Process	IBA	GO_REF:0000033
GO:1902806	regulation of cell cycle G1/S phase transition	Biological Process	IMP	PMID:23213251
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:19100260
GO:2001235	positive regulation of apoptotic signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:16189514

Enzyme–Substrate Interactions ▾

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