MSL2

Details:

UniProt Entry: Q9HCI7
Gene: MSL2
Class: RING
Family: RING9
Protein length: 577
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4b7y, 4b86

Protein Sequence ▾

>Q9HCI7
MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS
TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII
EAVDCSSDIL ALLNDGSLFC EETEKPSDSS FTLCLTHSPL PSTSEPTTDP QASLSPMSES
TLSIAIGSSV INGLPTYNGL SIDRFGINIP SPEHSNTIDV CNTVDIKTED LSDSLPPVCD
TVATDLCSTG IDICSFSEDI KPGDSLLLSV EEVLRSLETV SNTEVCCPNL QPNLEATVSN
GPFLQLSSQS LSHNVFMSTS PALHGLSCTA ATPKIAKLNR KRSRSESDSE KVQPLPISTI
IRGPTLGASA PVTVKRESKI SLQPIATVPN GGTTPKISKT VLLSTKSMKK SHEHGSKKSH
SKTKPGILKK DKAVKEKIPS HHFMPGSPTK TVYKKPQEKK GCKCGRATQN PSVLTCRGQR
CPCYSNRKAC LDCICRGCQN SYMANGEKKL EAFAVPEKAL EQTRLTLGIN VTSIAVRNAS
TSTSVINVTG SPVTTFLAAS THDDKSLDEA IDMRFDC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	116	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
5	577	Family	E3 ubiquitin-protein ligase MSL2	IPR037922	PTHR16048
42	111	Domain	E3 ubiquitin-protein ligase Msl2, zinc RING finger	IPR032043	PF16685
44	85	Domain	Zinc finger, RING-type	IPR001841	PS50089
456	508	Domain	E3 ubiquitin-protein ligase Msl2, CXC domain	IPR032049	PF16682
456	505	Domain	E3 ubiquitin-protein ligase Msl2, CXC domain	IPR032049	cd13122
457	504	Domain	Tesmin/TSO1-like CXC domain	IPR033467	SM01114

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IDA	PMID:11742995
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:21726816
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0040029	epigenetic regulation of gene expression	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000043
GO:0072487	MSL complex	Cellular Component	IEA	GO_REF:0000120
GO:0000785	chromatin	Cellular Component	IDA	PMID:21726816
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-3321883
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:16227571
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140585	promoter-enhancer loop anchoring activity	Molecular Function	ISS	GO_REF:0000024
GO:0141054	histone H2B ubiquitin ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾


P62807	H2B1C	Yes	Yes	No	No	—	No	Cluster-specific

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