>Q9HCE7 MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK LNPSDTDAVR GQIVVSLQTR DRIGTGGSVV DCRGLLENEG TVYEDSGPGR PLSCFMEEPA PYTDSTGAAA GGGNCRFVES PSQDQRLQAQ RLRNPDVRGS LQTPQNRPHG HQSPELPEGY EQRTTVQGQV YFLHTQTGVS TWHDPRIPSP SGTIPGGDAA FLYEFLLQGH TSEPRDLNSV NCDELGPLPP GWEVRSTVSG RIYFVDHNNR TTQFTDPRLH HIMNHQCQLK EPSQPLPLPS EGSLEDEELP AQRYERDLVQ KLKVLRHELS LQQPQAGHCR IEVSREEIFE ESYRQIMKMR PKDLKKRLMV KFRGEEGLDY GGVAREWLYL LCHEMLNPYY GLFQYSTDNI YMLQINPDSS INPDHLSYFH FVGRIMGLAV FHGHYINGGF TVPFYKQLLG KPIQLSDLES VDPELHKSLV WILENDITPV LDHTFCVEHN AFGRILQHEL KPNGRNVPVT EENKKEYVRL YVNWRFMRGI EAQFLALQKG FNELIPQHLL KPFDQKELEL IIGGLDKIDL NDWKSNTRLK HCVADSNIVR WFWQAVETFD EERRARLLQF VTGSTRVPLQ GFKALQGSTG AAGPRLFTIH LIDANTDNLP KAHTCFNRID IPPYESYEKL YEKLLTAVEE TCGFAVE
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 1 | 120 | Domain | C2 domain | IPR000008 | PS50004 |
| 1 | 149 | Family | E3 ubiquitin-protein ligase, SMURF1 type | IPR024928 | PIRSF001569 |
| 11 | 140 | Homologous_superfamily | C2 domain superfamily | IPR035892 | G3DSA:2.60.40.150 |
| 13 | 138 | Homologous_superfamily | C2 domain superfamily | IPR035892 | SSF49562 |
| 14 | 117 | Domain | C2 domain | IPR000008 | SM00239 |
| 14 | 102 | Domain | C2 domain | IPR000008 | PF00168 |
| 198 | 278 | Family | E3 ubiquitin-protein ligase, SMURF1 type | IPR024928 | PIRSF001569 |
| 231 | 268 | Homologous_superfamily | WW domain superfamily | IPR036020 | SSF51045 |
| 234 | 267 | Domain | WW domain | IPR001202 | PS50020 |
| 235 | 267 | Domain | WW domain | IPR001202 | SM00456 |
| 237 | 267 | Domain | WW domain | IPR001202 | cd00201 |
| 286 | 366 | Family | E3 ubiquitin-protein ligase, SMURF1 type | IPR024928 | PIRSF001569 |
| 301 | 341 | Homologous_superfamily | WW domain superfamily | IPR036020 | SSF51045 |
| 306 | 339 | Domain | WW domain | IPR001202 | PS50020 |
| 307 | 339 | Domain | WW domain | IPR001202 | SM00456 |
| 308 | 337 | Domain | WW domain | IPR001202 | PF00397 |
| 309 | 339 | Domain | WW domain | IPR001202 | cd00201 |
| 312 | 337 | Domain | WW domain | IPR001202 | PS01159 |
| 358 | 757 | Family | E3 ubiquitin-protein ligase, SMURF1 type | IPR024928 | PIRSF001569 |
| 386 | 750 | Homologous_superfamily | HECT, E3 ligase catalytic domain | IPR035983 | SSF56204 |
| 399 | 754 | Domain | HECT domain | IPR000569 | cd00078 |
| 418 | 757 | Domain | HECT domain | IPR000569 | SM00119 |
| 420 | 757 | Domain | HECT domain | IPR000569 | PS50237 |
| 449 | 756 | Domain | HECT domain | IPR000569 | PF00632 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0000209 | protein polyubiquitination | Biological Process | IDA | PMID:11278251 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | Biological Process | IEA | GO_REF:0000120 |
| GO:0006611 | protein export from nucleus | Biological Process | IDA | PMID:11278251 |
| GO:0007398 | ectoderm development | Biological Process | IEA | GO_REF:0000117 |
| GO:0016567 | protein ubiquitination | Biological Process | IEA | GO_REF:0000041 |
| GO:0030154 | cell differentiation | Biological Process | IEA | GO_REF:0000120 |
| GO:0030509 | BMP signaling pathway | Biological Process | IDA | PMID:21572392 |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | Biological Process | IEA | GO_REF:0000117 |
| GO:0030514 | negative regulation of BMP signaling pathway | Biological Process | IBA | GO_REF:0000033 |
| GO:0032801 | receptor catabolic process | Biological Process | IDA | PMID:12151385 |
| GO:0032926 | negative regulation of activin receptor signaling pathway | Biological Process | IDA | PMID:16720724 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | Biological Process | IBA | GO_REF:0000033 |
| GO:0045773 | positive regulation of axon extension | Biological Process | IEA | GO_REF:0000107 |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | Biological Process | IEA | GO_REF:0000117 |
| GO:0061736 | engulfment of target by autophagosome | Biological Process | IMP | PMID:22020285 |
| GO:0061753 | substrate localization to autophagosome | Biological Process | IMP | PMID:22020285 |
| GO:0071211 | protein targeting to vacuole involved in autophagy | Biological Process | IMP | PMID:22020285 |
| GO:0072659 | protein localization to plasma membrane | Biological Process | IDA | PMID:12151385 |
| GO:1903861 | positive regulation of dendrite extension | Biological Process | IDA | PMID:23999003 |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | Biological Process | IMP | PMID:21454619 |
| GO:0005739 | mitochondrion | Cellular Component | IGI | PMID:22020285 |
| GO:0005737 | cytoplasm | Cellular Component | IBA | GO_REF:0000033 |
| GO:0005886 | plasma membrane | Cellular Component | IDA | PMID:12151385 |
| GO:0005654 | nucleoplasm | Cellular Component | TAS | Reactome:R-HSA-8952419 |
| GO:0005829 | cytosol | Cellular Component | TAS | Reactome:R-HSA-201445 |
| GO:0016020 | membrane | Cellular Component | IEA | GO_REF:0000043 |
| GO:0030424 | axon | Cellular Component | IEA | GO_REF:0000107 |
| GO:0043025 | neuronal cell body | Cellular Component | IEA | GO_REF:0000107 |
| GO:0070062 | extracellular exosome | Cellular Component | HDA | PMID:19056867 |
| GO:0004842 | ubiquitin-protein transferase activity | Molecular Function | IEA | GO_REF:0000002 |
| GO:0005160 | transforming growth factor beta receptor binding | Molecular Function | IPI | PMID:12151385 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:15231748 |
| GO:0005543 | phospholipid binding | Molecular Function | TAS | PMID:22020285 |
| GO:0016740 | transferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0046332 | SMAD binding | Molecular Function | IBA | GO_REF:0000033 |
| GO:0061630 | ubiquitin protein ligase activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0070411 | I-SMAD binding | Molecular Function | IPI | PMID:11278251 |
| GO:0070412 | R-SMAD binding | Molecular Function | IPI | PMID:11278251 |
| GO:0070697 | activin receptor binding | Molecular Function | IPI | PMID:16720724 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|---|---|---|---|---|---|---|---|
| Q96C92 | ENTR1 | Yes | Yes | No | No | — | No | E3-specific |
| P67936 | TPM4 | Yes | Yes | No | No | — | No | E3-specific |
| Q8N519 | Q8N519 | Yes | Yes | No | No | — | No | E3-specific |
| Q9UM07 | PADI4 | Yes | Yes | No | No | — | No | E3-specific |
| Q9P2X3 | IMPCT | Yes | Yes | No | No | — | No | E3-specific |
| O95947 | TBX6 | Yes | Yes | No | No | — | No | E3-specific |
| Q8TB46 | Q8TB46 | Yes | Yes | No | No | — | No | E3-specific |
| P60002 | ELOF1 | Yes | Yes | No | No | — | No | E3-specific |
| O14730 | RIOK3 | Yes | Yes | No | No | — | No | E3-specific |
| Q8N6M0 | OTU6B | Yes | Yes | No | No | — | No | E3-specific |
| Q569H4 | LARGN | Yes | Yes | No | No | — | No | E3-specific |
| Q9NZ63 | TLS1 | Yes | Yes | No | No | — | No | E3-specific |
| Q99988 | GDF15 | Yes | Yes | No | No | — | No | E3-specific |
| Q9BRJ6 | CG050 | Yes | Yes | No | No | — | No | E3-specific |
| Q9P270 | SLAI2 | Yes | Yes | No | No | — | No | E3-specific |
| Q15726 | KISS1 | Yes | No | No | No | — | No | E3-specific |
| Q7Z4L4 | Q7Z4L4 | Yes | Yes | No | No | — | No | E3-specific |
| Q9H6K1 | ILRUN | Yes | Yes | No | No | — | No | E3-specific |
| P26038 | MOES | Yes | Yes | No | No | — | No | E3-specific |
| Q9NWM3 | CUED1 | Yes | Yes | No | No | — | No | E3-specific |
| P08133 | ANXA6 | Yes | Yes | No | No | — | No | E3-specific |
| Q9Y261 | FOXA2 | Yes | No | No | No | — | No | E3-specific |
| Q9Y4K4 | M4K5 | Yes | Yes | No | No | — | No | E3-specific |
| Q6ZVM7 | TM1L2 | Yes | Yes | No | No | — | No | E3-specific |
| P19784 | CSK22 | Yes | Yes | No | No | — | No | E3-specific |
| Q96CS3 | FAF2 | Yes | Yes | No | No | — | No | E3-specific |
| Q96KG9 | SCYL1 | Yes | Yes | No | No | — | No | E3-specific |
| P61086 | UBE2K | Yes | Yes | No | No | — | No | E3-specific |
| Q13492 | PICAL | Yes | Yes | No | No | — | No | E3-specific |
| O43541 | SMAD6 | Yes | Yes | No | No | — | No | Cluster-specific |
| Q00688 | FKBP3 | Yes | Yes | No | No | — | No | E3-specific |
| Q13873 | BMPR2 | Yes | Yes | No | No | — | No | E3-specific |
| A6NI79 | CCD69 | Yes | Yes | No | No | — | No | E3-specific |
| Q08881 | ITK | Yes | Yes | No | No | — | No | E3-specific |
| P48730 | KC1D | Yes | Yes | No | No | — | No | E3-specific |
| P45974 | UBP5 | Yes | Yes | No | No | — | No | E3-specific |
| Q8N8V4 | ANS4B | Yes | Yes | No | No | — | No | E3-specific |
| Q9H160 | ING2 | Yes | Yes | Yes | No | 20621832 | EBI-8068177 | E3-specific |
| P42679 | MATK | Yes | Yes | No | No | — | No | E3-specific |
| O76080 | ZFAN5 | Yes | Yes | No | No | — | No | E3-specific |
| Q9UKE5 | TNIK | Yes | Yes | No | No | — | No | E3-specific |
| Q9Y490 | TLN1 | Yes | Yes | No | No | — | No | E3-specific |
| Q9P1Z2 | CACO1 | Yes | Yes | No | No | — | No | E3-specific |
| Q9P2Y5 | UVRAG | Yes | Yes | No | No | — | No | E3-specific |
| Q16186 | ADRM1 | Yes | Yes | No | No | — | No | E3-specific |
| Q9H5N1 | RABE2 | Yes | Yes | No | No | — | No | E3-specific |
| P35626 | ARBK2 | Yes | Yes | No | No | — | No | E3-specific |
| Q99717 | SMAD5 | Yes | Yes | No | No | 15231748 | EBI-7239728 | Cluster-specific |
| P61077 | UB2D3 | Yes | Yes | No | No | — | No | E3-specific |
| P36894 | BMR1A | Yes | Yes | No | No | — | No | E3-specific |
| Q8N0X7 | SPART | Yes | Yes | No | No | 28514442 | EBI-21898246 | Cluster-specific |
| Q5BJF6 | ODFP2 | Yes | Yes | No | No | — | No | E3-specific |
| O00291 | HIP1 | Yes | Yes | No | No | — | No | E3-specific |
| Q15642 | CIP4 | Yes | Yes | No | No | — | No | E3-specific |
| Q7KZI7 | MARK2 | Yes | Yes | No | No | — | No | E3-specific |
| Q9Y6I3 | EPN1 | Yes | Yes | No | No | — | No | E3-specific |
| Q9Y508 | RN114 | Yes | Yes | No | No | — | No | E3-specific |
| Q04771 | ACVR1 | Yes | No | No | No | — | No | E3-specific |
| P05129 | KPCG | Yes | Yes | No | No | — | No | E3-specific |
| Q8NFZ5 | TNIP2 | Yes | Yes | No | No | — | No | E3-specific |
| Q9NSB8 | HOME2 | Yes | Yes | No | No | — | No | E3-specific |
| Q9UHD9 | UBQL2 | Yes | Yes | No | No | — | No | E3-specific |
| P80192 | M3K9 | Yes | Yes | No | No | — | No | E3-specific |
| Q02779 | M3K10 | Yes | Yes | No | No | — | No | E3-specific |
| Q9H2K8 | TAOK3 | Yes | Yes | No | No | — | No | E3-specific |
| P62253 | UB2G1 | Yes | Yes | No | No | — | No | E3-specific |
| Q13404 | UB2V1 | Yes | Yes | No | No | 25260751 | EBI-9971128 | E3-specific |
| Q8IZ07 | AN13A | Yes | Yes | No | No | — | No | E3-specific |
| Q9H1I8 | ASCC2 | Yes | Yes | No | No | — | No | E3-specific |
| Q92519 | TRIB2 | Yes | Yes | No | No | 25311538 | EBI-9827790 | E3-specific |
| Q9UMX0 | UBQL1 | Yes | Yes | No | No | — | No | E3-specific |
| P21709 | EPHA1 | Yes | Yes | No | No | — | No | E3-specific |
| P07332 | FES | Yes | Yes | No | No | — | No | E3-specific |
| Q15750 | TAB1 | Yes | Yes | No | No | — | No | Cluster-specific |
| O60784 | TOM1 | Yes | Yes | No | No | — | No | E3-specific |
| P61328 | FGF12 | Yes | Yes | No | No | — | No | E3-specific |
| Q6ZTN6 | AN13D | Yes | Yes | No | No | — | No | E3-specific |
| Q9BZV1 | UBXN6 | Yes | Yes | No | No | — | No | E3-specific |
| Q06187 | BTK | Yes | Yes | No | No | — | No | E3-specific |
| Q9H8M7 | MINY3 | Yes | Yes | No | No | — | No | E3-specific |
| O76013 | KRT36 | Yes | Yes | No | No | — | No | E3-specific |
| P54725 | RD23A | Yes | Yes | No | No | — | No | Cluster-specific |
| Q9BUZ4 | TRAF4 | Yes | Yes | Yes | No | 19937093 | EBI-9846454 | Cluster-specific |
| P41743 | KPCI | Yes | Yes | No | No | — | No | E3-specific |
| O00238 | BMR1B | Yes | Yes | No | No | — | No | E3-specific |
| Q9BSL1 | UBAC1 | Yes | Yes | No | No | — | No | E3-specific |
| Q9Y5W3 | KLF2 | Yes | Yes | Yes | No | 21382345 | EBI-9846746 | Cluster-specific |
| Q9ULJ7 | ANR50 | Yes | Yes | No | No | — | No | E3-specific |
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL3911739 | ChEMBL | 6.31 | — | — | CC1=CCC(c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)OC1 |
| E3 Binder | CHEMBL3908757 | ChEMBL | 8.68 | — | — | CCC1CC(C)CC=C1c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |
| E3 Binder | CHEMBL3918128 | ChEMBL | 8.74 | — | — | CCC1CC=C(c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)CC1 |
| E3 Binder | CHEMBL4446476 | ChEMBL | 6.57 | — | — | CCc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(-c4ccc(F)cc4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4465535 | ChEMBL | 6.25 | — | — | CCc1ccc2c(c1)CCc1c(C(=O)Nc3c(C)n(C)n(-c4ccccc4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4532915 | ChEMBL | 6.17 | — | — | CCn1c(C)c(NC(=O)c2noc3c2CCCc2cc(OC)ccc2-3)c(=O)n1-c1ccccc1Cl |
| E3 Binder | CHEMBL4543791 | ChEMBL | 6.19 | — | — | COC1CC(c2onc(C(=O)Nc3c(C)n(C)n(C4CCCC4)c3=O)c2C)OC(C(C)(C)C)C1 |
| E3 Binder | CHEMBL3953839 | ChEMBL | 7.0 | — | — | CO[C@@H]1C[C@@H](c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)O[C@@H](C(C)(C)C)C1 |
| E3 Binder | CHEMBL3982535 | ChEMBL | 6.14 | — | — | CO[C@H]1C[C@@H](C(C)(C)C)O[C@@H](c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)C1 |
| E3 Binder | CHEMBL3966224 | ChEMBL | 6.54 | — | — | CO[C@H]1C[C@@H](c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)O[C@@H](C(C)(C)C)C1 |
| E3 Binder | CHEMBL3970464 | ChEMBL | 6.05 | — | — | COc1ccc(-n2nnc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)c(C(F)(F)F)c1 |
| E3 Binder | CHEMBL3929850 | ChEMBL | 6.36 | — | — | COc1ccc(-n2nnc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)c(Cl)c1 |
| E3 Binder | CHEMBL4547904 | ChEMBL | 6.88 | — | — | COc1ccc2c(c1)CCCCc1c(C(=O)Nc3c(C)n(C)n(-c4ccccc4F)c3=O)noc1-2 |
| E3 Binder | CHEMBL4585952 | ChEMBL | 7.04 | — | — | COc1ccc2c(c1)CCCCc1c(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4567819 | ChEMBL | 6.06 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C(F)(F)F)n(C)n(-c4ccccc4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4439888 | ChEMBL | 6.3 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(-c4ccc(C)cc4C)c3=O)noc1-2 |
| E3 Binder | CHEMBL4540707 | ChEMBL | 6.39 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(-c4ccc(F)cc4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4566754 | ChEMBL | 6.18 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(-c4cccc(Cl)c4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4462198 | ChEMBL | 6.9 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(-c4ccccc4Cl)c3=O)noc1-2 |
| E3 Binder | CHEMBL4583928 | ChEMBL | 7.54 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(C4CCCC4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4441459 | ChEMBL | 8.23 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)noc1-2 |
| E3 Binder | CHEMBL4462646 | ChEMBL | 6.16 | — | — | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(Cc4ccccc4)c3=O)noc1-2 |
| E3 Binder | CHEMBL3967415 | ChEMBL | 6.0 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(-c3ccccc3F)c2=O)nnn1-c1ccc(C2CC2)cc1Cl |
| E3 Binder | CHEMBL3895951 | ChEMBL | 6.01 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C(C)C)c2=O)noc1C1CCCC(C(C)(C)C)O1 |
| E3 Binder | CHEMBL3945107 | ChEMBL | 6.54 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCC3)c2=O)noc1[C@@H]1CCC[C@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL3977739 | ChEMBL | 6.2 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCC3)c2=O)noc1[C@H]1CCC[C@@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL3933261 | ChEMBL | 7.04 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)nnn1-c1ccc(C2CC2)cc1Cl |
| E3 Binder | CHEMBL3981733 | ChEMBL | 6.64 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)nnn1-c1ccc(Cl)cc1C1CC1 |
| E3 Binder | CHEMBL3969407 | ChEMBL | 6.24 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)nnn1-c1ccc(Cl)cc1Cl |
| E3 Binder | CHEMBL3923243 | ChEMBL | 6.26 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)nnn1-c1ccc(OC(F)(F)F)cc1Cl |
| E3 Binder | CHEMBL3906702 | ChEMBL | 7.24 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1/C=C/C(C)(C)C |
| E3 Binder | CHEMBL3977353 | ChEMBL | 7.34 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1/C=C\C(C)(C)C |
| E3 Binder | CHEMBL3959606 | ChEMBL | 8.49 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C(C)(C)C)CC1 |
| E3 Binder | CHEMBL3945602 | ChEMBL | 8.55 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C(C)C)CC1 |
| E3 Binder | CHEMBL3937559 | ChEMBL | 7.48 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C(F)(F)F)CC1 |
| E3 Binder | CHEMBL3948012 | ChEMBL | 8.22 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)(C)C1 |
| E3 Binder | CHEMBL3903549 | ChEMBL | 9.05 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)(C)CC1 |
| E3 Binder | CHEMBL3923152 | ChEMBL | 8.22 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)CC1 |
| E3 Binder | CHEMBL3956674 | ChEMBL | 6.51 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(OC(C)C)CC1 |
| E3 Binder | CHEMBL3979914 | ChEMBL | 8.6 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC2(CCCC2)CC1 |
| E3 Binder | CHEMBL3942689 | ChEMBL | 7.19 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC2(CCCO2)CC1 |
| E3 Binder | CHEMBL3980364 | ChEMBL | 7.0 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC2(CCOC2)CC1 |
| E3 Binder | CHEMBL3936702 | ChEMBL | 7.85 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCCCC1(C)C |
| E3 Binder | CHEMBL3963970 | ChEMBL | 8.1 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCCCCC1 |
| E3 Binder | CHEMBL3978863 | ChEMBL | 6.2 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CC(Br)C(C)CO1 |
| E3 Binder | CHEMBL3924296 | ChEMBL | 6.8 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CC(C(C)(C)Br)CO1 |
| E3 Binder | CHEMBL3936144 | ChEMBL | 6.47 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CC(C(C)C)CO1 |
| E3 Binder | CHEMBL3933097 | ChEMBL | 7.04 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CC=CC(C(C)C)O1 |
| E3 Binder | CHEMBL3971227 | ChEMBL | 7.64 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC(C)(C)C1 |
| E3 Binder | CHEMBL3922163 | ChEMBL | 8.24 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC(C)(C)CC1 |
| E3 Binder | CHEMBL3949800 | ChEMBL | 8.85 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC(C)CO1 |
| E3 Binder | CHEMBL3977920 | ChEMBL | 6.38 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC2(CC1)OCCO2 |
| E3 Binder | CHEMBL3939778 | ChEMBL | 7.43 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCCC(C(C)(C)C)O1 |
| E3 Binder | CHEMBL3936863 | ChEMBL | 7.3 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCCCC1 |
| E3 Binder | CHEMBL3903305 | ChEMBL | 6.24 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1OCC(C)(C)CO1 |
| E3 Binder | CHEMBL3896562 | ChEMBL | 7.72 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1CCC(C)(C)C |
| E3 Binder | CHEMBL3948610 | ChEMBL | 8.85 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1CC[C@@H](C)CO1 |
| E3 Binder | CHEMBL3967213 | ChEMBL | 6.38 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1CC[C@H](C)CO1 |
| E3 Binder | CHEMBL3965072 | ChEMBL | 6.6 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1C[C@@H](C(C)C)CO1 |
| E3 Binder | CHEMBL3938251 | ChEMBL | 6.75 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1OCC(C)(C)O[C@H]1C |
| E3 Binder | CHEMBL3897219 | ChEMBL | 6.8 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1OC[C@@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL4111123 | ChEMBL | 7.12 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1OC[C@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL3928794 | ChEMBL | 6.46 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@H]1C[C@H](C(C)C)CO1 |
| E3 Binder | CHEMBL3898476 | ChEMBL | 6.08 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@H]1OC[C@@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL4113496 | ChEMBL | 7.13 | — | — | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@H]1OC[C@H](C(C)(C)C)O1 |
| E3 Binder | CHEMBL3975128 | ChEMBL | 7.26 | — | — | Cc1c(NC(=O)c2nnn3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C |
| E3 Binder | CHEMBL4522525 | ChEMBL | 6.33 | — | — | Cc1c(NC(=O)c2noc3c2CC2C(c4ccccc4-3)C2(Cl)Cl)c(=O)n(-c2ccccc2)n1C |
| E3 Binder | CHEMBL4592708 | ChEMBL | 6.18 | — | — | Cc1c(NC(=O)c2noc3c2CCCCc2ccccc2-3)c(=O)n(-c2ccccc2)n1C |
| E3 Binder | CHEMBL4468431 | ChEMBL | 7.65 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(CC(C)C)ccc2-3)c(=O)n(-c2ccccc2Cl)n1C |
| E3 Binder | CHEMBL4475920 | ChEMBL | 8.35 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2c(Cl)cccc2Cl)n1C |
| E3 Binder | CHEMBL4533744 | ChEMBL | 6.7 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2ccccc2)n1C |
| E3 Binder | CHEMBL4473531 | ChEMBL | 7.77 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2ccccc2F)n1C |
| E3 Binder | CHEMBL4584197 | ChEMBL | 8.66 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C |
| E3 Binder | CHEMBL4466006 | ChEMBL | 7.24 | — | — | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(Cc2ccccc2F)n1C |
| E3 Binder | CHEMBL4460342 | ChEMBL | 7.5 | — | — | Cc1c(NC(=O)c2noc3c2CCSc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2ccccc2F)n1C |
| E3 Binder | CHEMBL4559578 | ChEMBL | 8.59 | — | — | Cc1c(NC(=O)c2noc3c2CCSc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C |
| E3 Binder | CHEMBL4532439 | ChEMBL | 6.62 | — | — | Cc1c(NC(=O)c2noc3c2CCc2cc(CC(C)C)ccc2-3)c(=O)n(-c2ccccc2)n1C |
| E3 Binder | CHEMBL4461423 | ChEMBL | 7.01 | — | — | [2H]C([2H])([2H])n1c(C)c(NC(=O)c2nnn(-c3ccc(C4CC4)cc3Cl)c2C)c(=O)n1C1CCCCC1 |