ZBT20

Details:

UniProt Entry: Q9HC78
Gene: ZBTB20
Class: RING
Family: RING6
Protein length: 741
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9HC78
MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA
HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC
VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL
QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV
DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT
DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG
PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT
ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV
TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK
SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC
PAKFDQIEQF NDHMRMHVSD G

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
78	200	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
80	195	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
94	196	Domain	BTB/POZ domain	IPR000210	PF00651
104	197	Domain	BTB/POZ domain	IPR000210	SM00225
104	167	Domain	BTB/POZ domain	IPR000210	PS50097
576	628	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
578	600	Domain	Zinc finger C2H2-type	IPR013087	PF00096
578	605	Domain	Zinc finger C2H2-type	IPR013087	PS50157
578	600	Domain	Zinc finger C2H2-type	IPR013087	SM00355
580	600	Domain	Zinc finger C2H2-type	IPR013087	PS00028
606	633	Domain	Zinc finger C2H2-type	IPR013087	PS50157
606	628	Domain	Zinc finger C2H2-type	IPR013087	SM00355
606	628	Domain	Zinc finger C2H2-type	IPR013087	PF00096
608	628	Domain	Zinc finger C2H2-type	IPR013087	PS00028
614	671	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
634	656	Domain	Zinc finger C2H2-type	IPR013087	PF00096
634	656	Domain	Zinc finger C2H2-type	IPR013087	SM00355
634	661	Domain	Zinc finger C2H2-type	IPR013087	PS50157
636	656	Domain	Zinc finger C2H2-type	IPR013087	PS00028
662	684	Domain	Zinc finger C2H2-type	IPR013087	SM00355
662	684	Domain	Zinc finger C2H2-type	IPR013087	PF00096
662	689	Domain	Zinc finger C2H2-type	IPR013087	PS50157
664	684	Domain	Zinc finger C2H2-type	IPR013087	PS00028
715	737	Domain	Zinc finger C2H2-type	IPR013087	PF00096
715	741	Domain	Zinc finger C2H2-type	IPR013087	PS50157
715	737	Domain	Zinc finger C2H2-type	IPR013087	SM00355
717	737	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0010629	negative regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0032728	positive regulation of interferon-beta production	Biological Process	IEA	GO_REF:0000107
GO:0032755	positive regulation of interleukin-6 production	Biological Process	IEA	GO_REF:0000107
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process	IEA	GO_REF:0000107
GO:0045821	positive regulation of glycolytic process	Biological Process	ISS	GO_REF:0000024
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0046889	positive regulation of lipid biosynthetic process	Biological Process	ISS	GO_REF:0000024
GO:0055088	lipid homeostasis	Biological Process	ISS	GO_REF:0000024
GO:0071333	cellular response to glucose stimulus	Biological Process	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000976	transcription cis-regulatory region binding	Molecular Function	ISS	GO_REF:0000024
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IEA	GO_REF:0000117

Enzyme–Substrate Interactions ▾

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