PATZ1

Details:

UniProt Entry: Q9HBE1
Gene: PATZ1
Class: RING
Family: RING6
Protein length: 687
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2epp, 2epq, 2epr, 2eps, 2yt9

Protein Sequence ▾

>Q9HBE1
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA
ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF
AYTSRIVVRL ESFPELMTAA KFLLMRSVIE ICQEVIKQSN VQILVPPARA DIMLFRPPGT
SDLGFPLDMT NGAALAANSN GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG
PLSPQLLTSP FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR TRKQVACEIC
GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY HVRSHDGSVG KPYICQSCGK
GFSRPDHLNG HIKQVHTSER PHKCQTCNAS FATRDRLRSH LACHEDKVPC QVCGKYLRAA
YMADHLKKHS EGPSNFCSIC NRGFSSASYL KVHVKTHHGV PLPQVSRHQE PILNGGAAFH
CARTYGNKEG QKCSHQDPIE SSDSYGDLSD ASDLKTPEKQ SANGSFSCDM AVPKNKMESD
GEKKYPCPEC GSFFRSKSYL NKHIQKVHVR ALGGPLGDLG PALGSPFSPQ QNMSLLESFG
FQIVQSAFAS SLVDPEVDQQ PMGPEGK

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
13	158	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	164	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
30	159	Domain	BTB/POZ domain	IPR000210	PF00651
41	160	Domain	BTB/POZ domain	IPR000210	SM00225
41	130	Domain	BTB/POZ domain	IPR000210	PS50097
262	272	Conserved_site	HMG-I/HMG-Y, DNA-binding, conserved site	IPR000637	PS00354
292	314	Domain	Zinc finger C2H2-type	IPR013087	PS50157
292	314	Domain	Zinc finger C2H2-type	IPR013087	SM00355
294	314	Domain	Zinc finger C2H2-type	IPR013087	PS00028
354	405	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
355	377	Domain	Zinc finger C2H2-type	IPR013087	SM00355
355	382	Domain	Zinc finger C2H2-type	IPR013087	PS50157
357	377	Domain	Zinc finger C2H2-type	IPR013087	PF00096
357	377	Domain	Zinc finger C2H2-type	IPR013087	PS00028
383	405	Domain	Zinc finger C2H2-type	IPR013087	PF00096
383	410	Domain	Zinc finger C2H2-type	IPR013087	PS50157
383	405	Domain	Zinc finger C2H2-type	IPR013087	SM00355
385	405	Domain	Zinc finger C2H2-type	IPR013087	PS00028
392	451	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
413	436	Domain	Zinc finger C2H2-type	IPR013087	SM00355
413	436	Domain	Zinc finger C2H2-type	IPR013087	PF00096
413	441	Domain	Zinc finger C2H2-type	IPR013087	PS50157
415	436	Domain	Zinc finger C2H2-type	IPR013087	PS00028
442	464	Domain	Zinc finger C2H2-type	IPR013087	SM00355
442	469	Domain	Zinc finger C2H2-type	IPR013087	PS50157
444	464	Domain	Zinc finger C2H2-type	IPR013087	PS00028
465	519	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
468	489	Domain	Zinc finger C2H2-type	IPR013087	SM00355
495	519	Domain	Zinc finger C2H2-type	IPR013087	PS50157
495	517	Domain	Zinc finger C2H2-type	IPR013087	SM00355
497	518	Domain	Zinc finger C2H2-type	IPR013087	PS00028
594	629	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
605	628	Domain	Zinc finger C2H2-type	IPR013087	PS50157
605	628	Domain	Zinc finger C2H2-type	IPR013087	PF00096
605	628	Domain	Zinc finger C2H2-type	IPR013087	SM00355
607	628	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000107
GO:0008584	male gonad development	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0030217	T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000120
GO:0010596	negative regulation of endothelial cell migration	Biological Process	IEA	GO_REF:0000107
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	TAS	PMID:10713105
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0001673	male germ cell nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:36931259
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:10713105
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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