RC3H2

Details:

UniProt Entry: Q9HBD1
Gene: RC3H2
Class: RING
Family: RING7
Protein length: 1191
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4z30, 4z31, 4zlc, 4zld

Protein Sequence ▾

>Q9HBD1
MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD
IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS
LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL
WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG
HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW
SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI
DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR
QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATVRTFPLL NKVGVNNTVT TTAGNVISVI
GSTETTGKIV PSTNGISNAE NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD
SVTENKIGSP PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ
DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA SMPYADHYST
FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI WRPPMYQRDD IIRSNSLPPM
DVMHSSVYQT SLRERYNSLD GYYSVACQPP SEPRTTVPLP REPCGHLKTS CEEQIRRKPD
QWAQYHTQKA PLVSSTLPVA TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS
CGTIGSCINA IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP
IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR WSSYGNEATS
SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL LLQREANALA MQQKWNSLDE
GRHLTLNLLS KEIELRNGEL QSDYTEDATD TKPDRDIELE LSALDTDEPD GQSEPIEEIL
DIQLGISSQN DQLLNGMAVE NGHPVQQHQK EPPKQKKQSL GEDHVILEEQ KTILPVTSCF
SQPLPVSISN ASCLPITTSV SAGNLILKTH VMSEDKNDFL KPVANGKMVN S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	83	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
14	54	Domain	Zinc finger, RING-type	IPR001841	PS50089
14	53	Domain	Zinc finger, RING-type	IPR001841	SM00184
33	42	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
268	323	Domain	Roquin II	IPR041523	PF18386
409	441	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
410	438	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
410	437	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
411	437	Domain	Zinc finger, CCCH-type	IPR000571	PF00642

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0001782	B cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0009791	post-embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010608	post-transcriptional regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0035264	multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0042098	T cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0043029	T cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0048286	lung alveolus development	Biological Process	IEA	GO_REF:0000107
GO:0048535	lymph node development	Biological Process	IEA	GO_REF:0000107
GO:0048536	spleen development	Biological Process	IEA	GO_REF:0000107
GO:0060173	limb development	Biological Process	IEA	GO_REF:0000107
GO:0061470	T follicular helper cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0050852	T cell receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:2000320	negative regulation of T-helper 17 cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:2000628	regulation of miRNA metabolic process	Biological Process	ISS	GO_REF:0000024
GO:0000932	P-body	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0010494	cytoplasmic stress granule	Cellular Component	IBA	GO_REF:0000033
GO:0009986	cell surface	Cellular Component	IDA	PMID:10938276
GO:0016020	membrane	Cellular Component	IDA	PMID:10938276
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003725	double-stranded RNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0035613	RNA stem-loop binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003677	DNA binding	Molecular Function	IDA	PMID:10938276
GO:0003729	mRNA binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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