MARH7

Details:

UniProt Entry: Q9H992
Gene: MARCHF7
Class: RING
Family: RING7
Protein length: 704
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9H992
MESKPSRIPR RISVQPSSSL SARMMSGSRG SSLNDTYHSR DSSFRLDSEY QSTSASASAS
PFQSAWYSES EITQGARSRS QNQQRDHDSK RPKLSCTNCT TSAGRNVGNG LNTLSDSSWR
HSQVPRSSSM VLGSFGTDLM RERRDLERRT DSSISNLMDY SHRSGDFTTS SYVQDRVPSY
SQGARPKENS MSTLQLNTSS TNHQLPSEHQ TILSSRDSRN SLRSNFSSRE SESSRSNTQP
GFSYSSSRDE APIISNSERV VSSQRPFQES SDNEGRRTTR RLLSRIASSM SSTFFSRRSS
QDSLNTRSLN SENSYVSPRI LTASQSRSNV PSASEVPDNR ASEASQGFRF LRRRWGLSSL
SHNHSSESDS ENFNQESEGR NTGPWLSSSL RNRCTPLFSR RRREGRDESS RIPTSDTSSR
SHIFRRESNE VVHLEAQNDP LGAAANRPQA SAASSSATTG GSTSDSAQGG RNTGISGILP
GSLFRFAVPP ALGSNLTDNV MITVDIIPSG WNSADGKSDK TKSAPSRDPE RLQKIKESLL
LEDSEEEEGD LCRICQMAAA SSSNLLIEPC KCTGSLQYVH QDCMKKWLQA KINSGSSLEA
VTTCELCKEK LELNLEDFDI HELHRAHANE QAEYEFISSG LYLVVLLHLC EQSFSDMMGN
TNEPSTRVRF INLARTLQAH MEDLETSEDD SEEDGDHNRT FDIA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
538	618	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
544	614	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
551	608	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
552	607	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002643	regulation of tolerance induction	Biological Process	IEA	GO_REF:0000107
GO:0042130	negative regulation of T cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0060271	cilium assembly	Biological Process	IDA	PMID:25552655
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:24905733
GO:0008284	positive regulation of cell population proliferation	Biological Process	IMP	PMID:29295817
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Biological Process	IMP	PMID:29295817
GO:0050821	protein stabilization	Biological Process	IMP	PMID:29295817
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:1901799	negative regulation of proteasomal protein catabolic process	Biological Process	IMP	PMID:29295817
GO:1902018	negative regulation of cilium assembly	Biological Process	IDA	PMID:25552655
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Biological Process	IMP	PMID:29295817
GO:1902916	positive regulation of protein polyubiquitination	Biological Process	IMP	PMID:29295817
GO:1905524	negative regulation of protein autoubiquitination	Biological Process	IMP	PMID:29295817
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0036064	ciliary basal body	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005813	centrosome	Cellular Component	IDA	PMID:25552655
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000107
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0043130	ubiquitin binding	Molecular Function	ISS	GO_REF:0000024
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0097371	MDM2/MDM4 family protein binding	Molecular Function	IPI	PMID:29295817

Enzyme–Substrate Interactions ▾


Q9H992	MARH7	Yes	Yes	No	No	—	No	E3-specific

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