TRI45

Details:

UniProt Entry: Q9H8W5
Gene: TRIM45
Class: RING
Family: RING8
Protein length: 580
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2ds4

Protein Sequence ▾

>Q9H8W5
MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT TCLEQLEPFS
VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ VDLPMGGVKA LTIDHLAVND
VMLESLRGEG QGLVCDLCND REVEKRCQTC KANLCHFCCQ AHRRQKKTTY HTMVDLKDLK
GYSRIGKPIL CPVHPAEELR LFCEFCDRPV CQDCVVGEHR EHPCDFTSNV IHKHGDSVWE
LLKGTQPHVE ALEEALAQIH IINSALQKRV EAVAADVRTF SEGYIKAIEE HRDKLLKQLE
DIRAQKENSL QLQKAQLEQL LADMRTGVEF TEHLLTSGSD LEILITKRVV VERLRKLNKV
QYSTRPGVND KIRFCPQEKA GQCRGYEIYG TINTKEVDPA KCVLQGEDLH RAREKQTASF
TLLCKDAAGE IMGRGGDNVQ VAVVPKDKKD SPVRTMVQDN KDGTYYISYT PKEPGVYTVW
VCIKEQHVQG SPFTVMVRRK HRPHSGVFHC CTFCSSGGQK TARCACGGTM PGGYLGCGHG
HKGHPGHPHW SCCGKFNEKS ECTWTGGQSA PRSLLRTVAL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
24	105	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
29	53	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
29	97	Domain	Zinc finger, RING-type	IPR001841	SM00184
29	98	Domain	Zinc finger, RING-type	IPR001841	PS50089
44	53	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
130	176	Domain	B-box-type zinc finger	IPR000315	PS50119
130	176	Domain	B-box-type zinc finger	IPR000315	SM00336
186	227	Domain	B-box-type zinc finger	IPR000315	SM00336
186	222	Domain	B-box-type zinc finger	IPR000315	PS50119
188	224	Domain	B-box-type zinc finger	IPR000315	PF00643
234	360	Domain	B-box, C-terminal	IPR003649	SM00502
394	497	Repeat	Filamin/ABP280 repeat-like	IPR017868	PS50194
395	499	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
397	497	Homologous_superfamily	Immunoglobulin E-set	IPR014756	SSF81296
397	494	Repeat	Filamin/ABP280 repeat-like	IPR017868	PF00630
398	500	Repeat	Filamin/ABP280 repeat	IPR001298	SM00557

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006954	inflammatory response	Biological Process	IDA	PMID:34017102
GO:0060348	bone development	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:36681779
GO:0050728	negative regulation of inflammatory response	Biological Process	IDA	PMID:36681779
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:36681779
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0045171	intercellular bridge	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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