RMD5A

Details:

UniProt Entry: Q9H871
Gene: RMND5A
Class: RING
Family: RING1
Protein length: 391
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q9H871
MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD AELSGTLSLV
LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD ISSVGIDGCW QADSQRLLNE
VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ KEPFVELNRI LEALKVRVLR PALEWAVSNR
EMLIAQNSSL EFKLHRLYFI SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY
LRQGIENSPY VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK
AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM KLVCGHIISR
DALNKMFNGS KLKCPYCPME QSPGDAKQIF F

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	390	Family	Fyv10 family	IPR045098	PTHR12170
114	146	Domain	LIS1 homology motif	IPR006594	SM00667
114	146	Domain	LIS1 homology motif	IPR006594	PS50896
153	210	Domain	CTLH, C-terminal LisH motif	IPR006595	SM00668
153	210	Domain	CTLH, C-terminal LisH motif	IPR006595	PS50897
154	296	Domain	CTLH/CRA C-terminal to LisH motif domain	IPR024964	PF10607
208	302	Domain	CRA domain	IPR013144	SM00757
333	381	Domain	Protein RMD5 homologue A, degenerated RING finger	IPR037680	cd16794
336	377	Domain	Gid-type RING finger domain	IPR044063	PS51867
336	375	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9861563
GO:0000151	ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0034657	GID complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:17467196
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

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