RN167

Details:

UniProt Entry: Q9H6Y7
Gene: RNF167
Class: RING
Family: RING3
Protein length: 350
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9H6Y7
MHPAAFPLPV VVAAVLWGAA PTRGLIRATS DHNASMDFAD LPALFGATLS QEGLQGFLVE
AHPDNACSPI APPPPAPVNG SVFIALLRRF DCNFDLKVLN AQKAGYGAAV VHNVNSNELL
NMVWNSEEIQ QQIWIPSVFI GERSSEYLRA LFVYEKGARV LLVPDNTFPL GYYLIPFTGI
VGLLVLAMGA VMIARCIQHR KRLQRNRLTK EQLKQIPTHD YQKGDQYDVC AICLDEYEDG
DKLRVLPCAH AYHSRCVDPW LTQTRKTCPI CKQPVHRGPG DEDQEEETQG QEEGDEGEPR
DHPASERTPL LGSSPTLPTS FGSLAPAPLV FPGPSTDPPL SPPSSPVILV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
20	170	Domain	ZNRF4 /RNF13/RNF167, PA domain	IPR044744	cd02123
55	144	Domain	PA domain	IPR003137	PF02225
77	118	Homologous_superfamily	PA domain superfamily	IPR046450	SSF52025
207	279	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
229	272	Domain	Zinc finger, RING-type	IPR001841	PF13639
229	272	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
230	271	Domain	Zinc finger, RING-type	IPR001841	SM00184
230	272	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:1902532	negative regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0032418	lysosome localization	Biological Process	IDA	PMID:32409562
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:36528027
GO:0034198	cellular response to amino acid starvation	Biological Process	IDA	PMID:26972053
GO:0085020	protein K6-linked ubiquitination	Biological Process	IDA	PMID:36528027
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:26972053
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:36528027
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:16314844
GO:0035519	protein K29-linked ubiquitination	Biological Process	IDA	PMID:33594058
GO:0045786	negative regulation of cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0051640	organelle localization	Biological Process	IMP	PMID:24387786
GO:0051966	regulation of synaptic transmission, glutamatergic	Biological Process	IDA	PMID:23129617
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:35114100
GO:1990253	cellular response to leucine starvation	Biological Process	IDA	PMID:35114100
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000044
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000120
GO:0031090	organelle membrane	Cellular Component	IEA	GO_REF:0000117
GO:0005764	lysosome	Cellular Component	IDA	PMID:27808481
GO:0005765	lysosomal membrane	Cellular Component	IDA	PMID:27808481
GO:0036020	endolysosome membrane	Cellular Component	IDA	PMID:23129617
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0010008	endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:16314844
GO:0005515	protein binding	Molecular Function	IPI	PMID:16314844

Enzyme–Substrate Interactions ▾


Q96BI1	S22AI	Yes	Yes	No	No	—	No	E3-specific
Q8WTX7	CAST1	Yes	No	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96BI1	S22AI	Yes	Yes	No	No	—	No	E3-specific
Q8WTX7	CAST1	Yes	No	No	No	—	No	E3-specific