RNF41

Details:

UniProt Entry: Q9H4P4
Gene: RNF41
Class: RING
Family: RING4
Protein length: 317
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2fzp, 2gwf

Protein Sequence ▾

>Q9H4P4
MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC
GLEMPKDELP NHNCIKHLRS VVQQQQTRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI
RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA
SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM
VQEPGLVMIF AHGVEEI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	78	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
18	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
34	43	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
78	138	Domain	Zinc finger, SIAH-type	IPR013010	PS51081
79	132	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
137	315	Domain	E3 ubiquitin-protein ligase NRDP1	IPR015036	PF08941
194	316	Homologous_superfamily	NRDP1, C-terminal	IPR037255	SSF160088

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:17145873
GO:0030336	negative regulation of cell migration	Biological Process	IMP	PMID:17145873
GO:0043408	regulation of MAPK cascade	Biological Process	IDA	PMID:17145873
GO:0045619	regulation of lymphocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045637	regulation of myeloid cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:17145873
GO:1901525	negative regulation of mitophagy	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0010498	proteasomal protein catabolic process	Biological Process	IDA	PMID:18541373
GO:0045732	positive regulation of protein catabolic process	Biological Process	IMP	PMID:27353365
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24105792
GO:0097191	extrinsic apoptotic signaling pathway	Biological Process	IDA	PMID:14765125
GO:2000377	regulation of reactive oxygen species metabolic process	Biological Process	IMP	PMID:18541373
GO:2000379	positive regulation of reactive oxygen species metabolic process	Biological Process	IMP	PMID:18541373
GO:0071782	endoplasmic reticulum tubular network	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1358789
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:27353365
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:14765125
GO:0005128	erythropoietin receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005135	interleukin-3 receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:11867753
GO:0019904	protein domain specific binding	Molecular Function	IPI	PMID:27353365
GO:0030971	receptor tyrosine kinase binding	Molecular Function	IPI	PMID:27353365
GO:0031267	small GTPase binding	Molecular Function	IPI	PMID:24056301

Enzyme–Substrate Interactions ▾


P11678	PERE	Yes	Yes	No	No	—	No	E3-specific
Q9NR09	BIRC6	Yes	Yes	No	No	—	No	E3-specific
Q9HB71	CYBP	Yes	No	No	No	25036637	EBI-9393233	Cluster-specific
P17676	CEBPB	Yes	Yes	No	No	—	No	E3-specific
Q99836	MYD88	Yes	Yes	No	No	—	No	E3-specific

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